CO-CRYSTAL OF MELITRACEN AND FLUPENTIXOL AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2021/023119

A1

Provided is a co-crystal formed by flupentixol dihydrochloride and melitracen hydrochloride, wherein the molar ratio of flupentixol dihydrochloride and melitracen hydrochloride in the co-crystal is 1:1. The co-crystal has a good stability and a high solubility, and has a pharmaceutical effect superior to that of commercially available Deanxit tablets and with less side effects.

WO/1998/056752	COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES
WO/1990/007493	METHYL ESTERS OF ALDIMINO- OR KETIMINO-OXY-ORTHO-TOLYLACRYLIC ACID, MANUFACTURING PROCESS AND FUNGICIDES CONTAINING THEM

LUO HUAN (CN)
LU PING (CN)
JIANG YU (CN)
XU XIANGYANG (CN)
ZHANG CHANGQING (CN)
ZHOU JUN (CN)
QIAN HUAJIANG (CN)
ZHAO ZHENKUN (CN)
LIU ZHIQIANG (CN)
HOU YUANYUAN (CN)

PCT/CN2020/106328

February 11, 2021

July 31, 2020

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NHWA PHARMA CORP (CN)
SUZHOU NHWA PHARMACEUTICAL RES CO LTD (CN)

C07D335/20; A61K31/135; A61K31/496; A61P25/00; A61P25/22; A61P25/24; C07C209/00; C07C209/84; C07C211/31

CN104177330A	2014-12-03
CN104288153A	2015-01-21
CN108498470A	2018-09-07
CN109674754A	2019-04-26
EP2374450A1	2011-10-12

SANDEE KUMAR , ARUN NANDA: "Approaches to Design of Pharmaceutical Cocrystals: A Review", MOLECULAR CRYSTALS AND LIQUID CRYSTALS, vol. 667, no. 1, 3 April 2019 (2019-04-03), pages 54 - 77, XP055777404, ISSN: 1542-1406, DOI: 10.1080/15421406.2019.1577462

NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)

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