CO-CRYSTAL OF OLAPARIB AND UREA AND PREPARATION METHOD THEREFOR

Title:

CO-CRYSTAL OF OLAPARIB AND UREA AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2016/165650

Kind Code:

A1

Abstract:

Disclosed are a co-crystal of olaparib and urea and a preparation method therefor. Specifically disclosed is a co-crystal form A, and an X-ray powder diffraction pattern of this crystal form has characteristic peaks at points where 2theta value is 17.4°±0.2°, 20.7°±0.2°, 10.5°±0.2°. The disclosed co-crystal has better stability, lower hygroscopicity and higher solubility as compared to existing olaparib free alkali crystal forms.

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Inventors:

CHEN MINHUA (CN)
ZHANG YANFENG (CN)
LIU KAI (CN)
ZHANG XIAOYU (CN)

Application Number:

PCT/CN2016/079430

Publication Date:

October 20, 2016

Filing Date:

April 15, 2016

Export Citation:

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Assignee:

CRYSTAL PHARMATECH CO LTD (CN)

International Classes:

C07D237/32; A61K31/502; A61P35/00; C07C273/02

Foreign References:

CN101528714A	2009-09-09
CN101821242A	2010-09-01

Other References:

NARWAL, M. ET AL.: "Structural Basis of Selective Inhibition of Human Tankyrases", J.MED.CHEM., vol. 55, no. 3, 10 January 2012 (2012-01-10), pages 1360 - 1367, XP055166829

Attorney, Agent or Firm:

SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
苏州创元专利商标事务所有限公司 (CN)

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