Title:
CO-CRYSTALS OF LITHIUM BENZOATE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/215592
Kind Code:
A1
Abstract:
The present disclosure provides co-crystals of a lithium benzoatecompound and a co-former compound of Formula (I). Also provided herein are methods of preparing the co-crystals and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, bipolar disorders, or neurodegenerative disorders).
Inventors:
TSAI GUOCHUAN EMIL (US)
WANG CHING-CHENG (CN)
HSIEH TIEN-LAN (CN)
LO YUAN-CHUN (CN)
WANG CHING-CHENG (CN)
HSIEH TIEN-LAN (CN)
LO YUAN-CHUN (CN)
Application Number:
PCT/CN2017/088044
Publication Date:
December 21, 2017
Filing Date:
June 13, 2017
Export Citation:
Assignee:
SYNEURX INT (TAIWAN) CORP (CN)
International Classes:
C07C215/54; A61K31/137; A61K33/14; A61P35/00; C07D213/80
Domestic Patent References:
| WO2012129568A2 | 2012-09-27 | |||
| WO2014172650A1 | 2014-10-23 |
Foreign References:
| CN105218386A | 2016-01-06 | |||
| US20130102781A1 | 2013-04-25 | |||
| RU2582962C1 | 2016-04-27 | |||
| US20130338199A1 | 2013-12-19 |
Other References:
BUTTERHOF, CHRISTIAN ET AL.: "Influence of Cation Size on the Co-crystallisation of Benzoic Acid with Different Benzoates", Z. ANORG. ALLG. CHEM, vol. 639, no. 2, 4 January 2013 (2013-01-04), pages 308 - 311, XP055449271
S MITH, ADAM J. ET AL.: "Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals", MOL. PHARMACEUTICS, vol. 12, no. 10, 5 November 2013 (2013-11-05), pages 4728 - 4738, XP002727756
BAK, ANNETTE ET AL.: "The Co-Crystal Approach to Improve the Exposure of a Water-Insoluble Compound: AMG 517 Sorbic Acid Co-Crystal Characterization and Pharmacokinetics", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 197, no. 9, 30 September 2008 (2008-09-30), pages 3942 - 3956, XP055055454
T. W. GREENEP. G. M. WUTS: "Protecting Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITHMARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS, INC.
LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC.
CARRUTHERS: "Some Modern Methods of Organic Synthesis", 1987, CAMBRIDGE UNIVERSITY PRESS
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 2725 - 19
ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
BUNDGARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-24
"Diagnostic and Statistical Manual of Mental Disorders", 1994, AMERICAN PSYCHIATRIC ASSOCIATION
S MITH, ADAM J. ET AL.: "Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals", MOL. PHARMACEUTICS, vol. 12, no. 10, 5 November 2013 (2013-11-05), pages 4728 - 4738, XP002727756
BAK, ANNETTE ET AL.: "The Co-Crystal Approach to Improve the Exposure of a Water-Insoluble Compound: AMG 517 Sorbic Acid Co-Crystal Characterization and Pharmacokinetics", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 197, no. 9, 30 September 2008 (2008-09-30), pages 3942 - 3956, XP055055454
T. W. GREENEP. G. M. WUTS: "Protecting Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITHMARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS, INC.
LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC.
CARRUTHERS: "Some Modern Methods of Organic Synthesis", 1987, CAMBRIDGE UNIVERSITY PRESS
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 2725 - 19
ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
BUNDGARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-24
"Diagnostic and Statistical Manual of Mental Disorders", 1994, AMERICAN PSYCHIATRIC ASSOCIATION
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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