Title:
CO-CRYSTALS OF RIBOCICLIB AND CO-CRYSTALS OF RIBOCICLIB MONO-SUCCINATE, PREPARATION METHOD THEREFOR, COMPOSITIONS THEREOF, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/062854
Kind Code:
A1
Abstract:
The present invention relates to co-crystals of ribociclib and co-crystals of ribociclib mono-succinate, comprising co-crystals between ribociclib and saccharin, co-crystals between ribociclib and cholic acid, co-crystals between ribociclib and orotic acid, and co-crystals between ribociclib mono-succinate and citric acid. Compared with the prior art, the co-crystals have one or more improved characters. The present invention also relates to a preparation method for the co-crystals between ribociclib and saccharin, the co-crystals between ribociclib and cholic acid, the co-crystals between ribociclib and orotic acid and the co-crystals between ribociclib mono-succinate and citric acid, pharmaceutical compositions thereof, and uses thereof in the preparation of drugs for treating and/or preventing diseases involving in one or more symptoms of protein kinase-related dysfunctions, cancers, transplant rejection and autoimmune diseases.
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Inventors:
SHENG XIAOHONG (CN)
SHENG XIAOXIA (CN)
CHEN JIAN (CN)
SHENG XIAOXIA (CN)
CHEN JIAN (CN)
Application Number:
PCT/CN2018/108334
Publication Date:
April 04, 2019
Filing Date:
September 28, 2018
Export Citation:
Assignee:
SOLIPHARMA LLC (CN)
International Classes:
C07D487/04; A61K31/519; A61P35/00
Foreign References:
| CN105753869A | 2016-07-13 | |||
| CN105085533A | 2015-11-25 | |||
| CN102186856A | 2011-09-14 |
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
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