Title:
DRUG/SIRNA CO-DELIVERY NANOCOMPLEX, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/142357
Kind Code:
A1
Abstract:
Disclosed are a drug/siRNA co-delivery nanocomplex, a method for preparing same, and use thereof. The nanocomplex comprises: a nanocore carrying a drug, a cationic polymer coating the nanocore, and siRNA. The nanocomplex may be PD@RPPT/sVNCs, wherein PD is a PLGA nanocore carrying dexamethasone (DXM), RPPT is a ditellurium cross-linked polyethyleneimine (PEI) with endothelial cell-targeting and ROS-responsive degradation capacities, and siVCAM-1 is VCAM-1 siRNA.
Inventors:
YIN LICHEN (CN)
HOU MENGYING (CN)
HOU MENGYING (CN)
Application Number:
PCT/CN2022/100874
Publication Date:
August 03, 2023
Filing Date:
June 23, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K45/06; A61K31/573; A61K31/713; A61K47/34; A61P9/10; A61P29/00; B82Y5/00; B82Y40/00
Domestic Patent References:
| WO2019104760A1 | 2019-06-06 |
Foreign References:
| US20120207795A1 | 2012-08-16 |
Other References:
XU, XIN: "Research on Polymer Nanocarrier Materials for Gene Delivery", ENGINEERING SCIENCE AND TECHNOLOGY I, CHINA MASTER'S THESES FULL-TEXT DATABASE, no. 1, 15 January 2019 (2019-01-15), ISSN: 1674-0246
DANG, JUANJUAN: "Multifunctional siRNA Nano-Delivery System for Synergistic Tumor Photothermal Therapy and Tumor Drug Resistance Reversal", ENGINEERING SCIENCE AND TECHNOLOGY I, CHINA MASTER'S THESES FULL-TEXT DATABASE, no. 4, 15 April 2020 (2020-04-15), ISSN: 1674-0246
MENG, YUE ET AL.: "Research Progress of Cationic Nanocarriers for Anti-Tumor Nucleic Acid Drugs", CHINA MEDICINAL BIOTECH ASSOCIATION, vol. 15, no. 4, 31 August 2020 (2020-08-31), pages 418 - 425, XP009547648, ISSN: 1673-713X
DANG, JUANJUAN: "Multifunctional siRNA Nano-Delivery System for Synergistic Tumor Photothermal Therapy and Tumor Drug Resistance Reversal", ENGINEERING SCIENCE AND TECHNOLOGY I, CHINA MASTER'S THESES FULL-TEXT DATABASE, no. 4, 15 April 2020 (2020-04-15), ISSN: 1674-0246
MENG, YUE ET AL.: "Research Progress of Cationic Nanocarriers for Anti-Tumor Nucleic Acid Drugs", CHINA MEDICINAL BIOTECH ASSOCIATION, vol. 15, no. 4, 31 August 2020 (2020-08-31), pages 418 - 425, XP009547648, ISSN: 1673-713X
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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