Title:
CO-SIGNALING METHODS FOR TREATING CANCERS
Document Type and Number:
WIPO Patent Application WO/2010/141093
Kind Code:
A3
Abstract:
Provided herein is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: expanding γδ T lymphocytes in vitro; priming Natural Kill cells in vitro; and administering said expanded γδ T lymphocytes and said primed Natural Kill cells to said individual, thereby resulting in a cytotoxic or cytolytic effect. Further provided is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: administering a compound to said individual that activates yδ T lymphocytes; and administering an antibody directed against a tumor antigen associated with said neoplastic disease.
Inventors:
STROME SCOTT E (US)
SCHULZE DAN H (US)
CHAPOVAL ANDREI (US)
SCHULZE DAN H (US)
CHAPOVAL ANDREI (US)
Application Number:
PCT/US2010/001625
Publication Date:
April 21, 2011
Filing Date:
June 04, 2010
Export Citation:
Assignee:
UNIV MARYLAND (US)
STROME SCOTT E (US)
SCHULZE DAN H (US)
CHAPOVAL ANDREI (US)
STROME SCOTT E (US)
SCHULZE DAN H (US)
CHAPOVAL ANDREI (US)
International Classes:
A61K38/16; A61K38/20; A61K39/395; A61P35/00
Foreign References:
| US20080199475A1 | 2008-08-21 | |||
| US6045788A | 2000-04-04 | |||
| US20050164306A1 | 2005-07-28 |
Other References:
ALEXANDER A.A. ET AL: "Isopentenyl pyrophosphate-activated CD56+{gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma", CLIN CANCER RES., vol. 14, no. 13, July 2008 (2008-07-01), pages 4232 - 4240
Attorney, Agent or Firm:
ADLER, Benjamin, Aaron (8011 Candle LaneHouston, TX, US)
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