Title:
COAGULATION AND FIBRINOLYTIC CASCADES MODULATOR
Document Type and Number:
WIPO Patent Application WO2006096345
Kind Code:
A3
Abstract:
The invention provides a thromboplastin reagent comprising: tissue factor, a phospholipid and a polyphosphate that acts as a blocker of tissue factor pathway inhibitor (TFPI). Also provided are a composition for promoting clotting comprising polyphosphate, and a reagent for a clotting assay also comprising polyphosphate together with an activator of clotting. Methods for stopping or slowing wound bleeding and fibrinolysis using compositions comprising polyphosphate are also disclosed.
Inventors:
MORRISSEY JAMES H (US)
SMITH STEPHANIE A (US)
DOCAMPO ROBERTO (US)
MUTCH NICOLA J (US)
SMITH STEPHANIE A (US)
DOCAMPO ROBERTO (US)
MUTCH NICOLA J (US)
Application Number:
PCT/US2006/006642
Publication Date:
November 30, 2006
Filing Date:
February 23, 2006
Export Citation:
Assignee:
UNIV ILLINOIS (US)
MORRISSEY JAMES H (US)
SMITH STEPHANIE A (US)
DOCAMPO ROBERTO (US)
MUTCH NICOLA J (US)
MORRISSEY JAMES H (US)
SMITH STEPHANIE A (US)
DOCAMPO ROBERTO (US)
MUTCH NICOLA J (US)
International Classes:
C12Q1/56; C07K14/745
Domestic Patent References:
| WO2004110462A1 | 2004-12-23 |
Foreign References:
| EP0727434A1 | 1996-08-21 | |||
| US5314695A | 1994-05-24 | |||
| US5625036A | 1997-04-29 | |||
| US6187347B1 | 2001-02-13 | |||
| DE1617733A1 | 1971-04-08 |
Other References:
SMITH STEPHANIE A ET AL: "Polyphosphate modulates blood coagulation and fibrinolysis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 103, no. 4, January 2006 (2006-01-01), pages 903 - 908, XP002391409, ISSN: 0027-8424
BLADBJERG E M ET AL: "In vitro effects of heparin and tissue factor pathway inhibitor on factor VII assays. possible implications for measurements in vivo after heparin therapy.", BLOOD COAGULATION & FIBRINOLYSIS : AN INTERNATIONAL JOURNAL IN HAEMOSTASIS AND THROMBOSIS. DEC 2000, vol. 11, no. 8, December 2000 (2000-12-01), pages 739 - 745, XP009069876, ISSN: 0957-5235
HANSEN J B ET AL: "Reduction of factor FVIIa activity during heparin therapy. Evidence for assay interactions with tissue factor pathway inhibitor and antithrombin.", THROMBOSIS RESEARCH. 1 DEC 2000, vol. 100, no. 5, 1 December 2000 (2000-12-01), pages 389 - 396, XP002392325, ISSN: 0049-3848
SMITH S A ET AL: "Properties of recombinant human thromboplastin that determine the International Sensitivity Index (ISI).", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH. SEP 2004, vol. 2, no. 9, September 2004 (2004-09-01), pages 1610 - 1616, XP002391410, ISSN: 1538-7933
BLADBJERG E M ET AL: "In vitro effects of heparin and tissue factor pathway inhibitor on factor VII assays. possible implications for measurements in vivo after heparin therapy.", BLOOD COAGULATION & FIBRINOLYSIS : AN INTERNATIONAL JOURNAL IN HAEMOSTASIS AND THROMBOSIS. DEC 2000, vol. 11, no. 8, December 2000 (2000-12-01), pages 739 - 745, XP009069876, ISSN: 0957-5235
HANSEN J B ET AL: "Reduction of factor FVIIa activity during heparin therapy. Evidence for assay interactions with tissue factor pathway inhibitor and antithrombin.", THROMBOSIS RESEARCH. 1 DEC 2000, vol. 100, no. 5, 1 December 2000 (2000-12-01), pages 389 - 396, XP002392325, ISSN: 0049-3848
SMITH S A ET AL: "Properties of recombinant human thromboplastin that determine the International Sensitivity Index (ISI).", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH. SEP 2004, vol. 2, no. 9, September 2004 (2004-09-01), pages 1610 - 1616, XP002391410, ISSN: 1538-7933
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