Title:
COATING COMPOSITION, HYDROGEL COATING AND PREPARATION METHOD THEREFOR, AND COATED PRODUCT
Document Type and Number:
WIPO Patent Application WO/2022/021363
Kind Code:
A1
Abstract:
The present invention relates to a coating composition, a hydrogel coating and a preparation method therefor, and a coated product. The coating composition comprises the following components in parts by weight: 2-100 parts of polyethylene glycol diacrylate, 0.02-2 parts of a thrombin-responsive crosslinking agent, 0.001-0.2 part of fibrinolytic active molecules, 0.002-1 part of a photosensitizer, and 50-2000 parts of a solvent. After the coating composition is cured, a hydrogel coating is obtained. The system can encapsulate the fibrinolytic active molecules while forming the hydrogel coating by crosslinking, thereby forming a thrombin-responsive hydrogel coating. During a process of thrombin-responsive release of the fibrinolytic active molecules, the hydrogel coating is not completely degraded and can continuously provide the surface with anti-protein adsorption properties. The hydrogel coating not only achieves a thrombotic stress fibrinolysis function, but also can maintain biological inertia in a non-thrombotic environment.
Inventors:
CHEN HONG (CN)
LI DAN (CN)
TANG ZENGCHAO (CN)
HUANG JIALEI (CN)
LI DAN (CN)
TANG ZENGCHAO (CN)
HUANG JIALEI (CN)
Application Number:
PCT/CN2020/106301
Publication Date:
February 03, 2022
Filing Date:
July 31, 2020
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61F2/00; A61L33/16; A61L27/34; A61L33/18; B05D3/06
Domestic Patent References:
| WO2014087325A1 | 2014-06-12 |
Foreign References:
| CN104861177A | 2015-08-26 | |||
| CN104955495A | 2015-09-30 | |||
| CN107519543A | 2017-12-29 | |||
| CN105903091A | 2016-08-31 |
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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