Title:
COCAINE RECEPTOR BINDING LIGANDS
Document Type and Number:
WIPO Patent Application WO/1993/009814
Kind Code:
A1
Abstract:
Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have formula (I), wherein Y = CH2R3, CO2R2 or (II), R1 = hydrogen, C1-5 alkyl, R2 = hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C1-4 alkoxy, C1-6 alkynyl, halogen or amine, R3 = OH, hydrogen, C1-6 alkyl, C3-8 cycloalkyl, C1-4 alkoxy, Cl, Br, I, CN, NH2, NHC1-6 alkyl, NC1-6 alkyl, OCOC1-6 alkyl, OCOC1-3 alkylaryl, A = S, O or NH, X = H, C1-6 alkyl, C3-8 cycloalkyl, C1-4 alkoxy, C1-6 alkynyl, halogen, amino, acylamido, and Z = H, I, Br, C1, F, CN, CF3 NO2, N3, OR1, CO2NH2, CO2R1, C1-6 alkyl, NR4R5, NHCOR5, NHCO2R6, wherein R4-R6 are each C1-6 alkyl.
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Inventors:
KUHAR MICHAEL J (US)
BOJA JOHN W (US)
CARROL FRANK IVY (US)
LEWIN ANITA H (US)
ABRAHAM PHILIP (US)
BOJA JOHN W (US)
CARROL FRANK IVY (US)
LEWIN ANITA H (US)
ABRAHAM PHILIP (US)
Application Number:
PCT/US1992/009482
Publication Date:
May 27, 1993
Filing Date:
November 13, 1992
Export Citation:
Assignee:
RES TRIANGLE INST (US)
NAT INST HEALTH (US)
NAT INST HEALTH (US)
International Classes:
A61K49/00; A61K51/04; C07B59/00; C07D253/02; A61K51/00; C07D451/02; G01N33/53; (IPC1-7): A61K43/00; A61K49/02; C07D451/00; C07D451/02
Foreign References:
US4179567A | 1979-12-18 | |||
US5128118A | 1992-07-07 | |||
US3813404A | 1974-05-28 |
Other References:
See also references of EP 0644775A4
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