COCRYSTALHZATION METHODS

This application claims the benefit of priority to provisional application no. 60/721 ,115, filed on September 28, 2005, the contents of which are incorporated by reference herein.

Cocrystals are crystals that contain two or more non-identical molecules. Examples of cocrystals may be found in the Cambridge Structural Database. Examples of cocrystals may also be found at Etter, Margaret C, and Daniel A. Adsmond (1990) "The use of cocrystallization as a method of studying hydrogen bond preferences of 2-aminopyridine" J. Chem. Soc, Chem. Commun. 1990 589-59 1 , Etter, Margaret C, John C. MacDonald, and Joel Bernstein (1990a) "Graph-set analysis of hydrogen-bond patterns in organic crystals" Acta Crystallogr., Sect. B, Struct. Sci. B46 256-262, Etter, Margaret C, Zofia Urbanczyk-Lipkowska, Mohammad Zia-Ebrahimi, and Thomas W. Panunto (1990b) "Hydrogen bond directed cocrystallization and molecular recognition properties of diarylureas" J. Am. Chem. Soc. 112 8415-8426, which are incorporated herein by reference in their entireties. The following articles are also incorporated herein by reference in their entireties: Carl Henrik Gδrbotz and Hans-Petter Hersieth, 2000, "On the inclusion of solvent molecules in the crystal structures of organic compounds" Acta Cryst. (2000), B56, 625-534; and V.S. Senthil Kumar, Ashwini Nangia, Amy K. Katz and H. L. Carrell, 2002, "Molecular Complexes of Some Mono- and Dicarboxylic Acids with trans-1 ,4,-Dithiane-1 ,4-dioxide" American Chemical Society, Crystal Growth & Design, Vol. 2, No. 4, 2002.

By cocrystallizing an active agent with a guest, one can create new solid state phases which may have improved properties over existing solid state phases of that active agent. For example, new drug formulations comprising cocrystals of active pharmaceutical ingredients (APIs) with pharmaceutically acceptable guests may have superior properties over existing drug formulations. The active agent and guest will vary depending on the industry. For example, in the pharmaceutical field, the active agent may be an API, and the other component of the cocrystal (the guest) must be a pharmaceutically acceptable compound (which could also be an API). Active agents and guests may also include nutraceuticals, agricultural chemicals,

pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials.

The methods of the disclosure may be employed to generate a wide variety of cocrystals of active agents and guests. For example, the methods of the disclosure may be used to generate cocrystals of a salt of an active agent, such as a salt of an active pharmaceutical ingredient, with a neutral guest. Alternatively, a cocrystal of a neutral or zwitterionic active agent (or a salt of an active agent) may be generated with a guest salt, which includes a positive ion and a negative ion of its own. Where the active agent is provided in a salt, it may be positively or negatively charged and have a negative or positive counterion.

Physical properties of active agents, or their salts, may be modified by forming a cocrystal. Such properties include melting point, density, hygroscopicity, crystal morphology, loading volume, compressibility, and shelf life. Furthermore, other properties such as bioavailability, toxicity, taste, physical stability, chemical stability, production costs, and manufacturing method may be modified by using a cocrystal rather than the active agent alone, or as a salt.

An active agent can be screened for possible cocrystals where polymorphic forms, hydrates, or solvates are especially problematic. For example, a neutral compound that can only be isolated as amorphous material could be cocrystallized. Forming a cocrystal may up-grade the performance of a drug formulation of an active pharmaceutical ingredient by, for example, changing physical properties identified earlier.

A cocrystal can be used to isolate or purify a compound during manufacturing. If it is desirable to identify all of the solid state phases of an active pharmaceutical ingredient, then cocrystallization may be particularly desirable.

One method of preparing cocrystals involves combining melts of active agents and guests using the Kofler contact method. In a typical Kofler experiment, an active agent is heated to its melting point and then combined, in the melt state with a guest, which is also in the form of a melt. For example, the two melts are placed under a cover slip which then causes the two melts to combine and interact with one another at the interface region of where the two melts contact each other. Sometimes paraffin oil or silicon oil, which are oils wherein the active agents are insoluble, are used to help mobilize either the active agent of the guest. In these methods, it is not

possible to prepare cocrystals of compounds which decompose prior to melting. In other circumstances, it is inconvenient or difficult to work with melts at high temperatures. In some instances and on some equipment, high temperatures such as those greater than about 200 ⁰ C may be inconvenient to use. Therefore, it would be advantageous to have a method wherein one could prepare cocrystals of active agents and guests which would not require heating to temperatures that either caused the active agent to decompose, that were above about 200 ⁰ C, or both.

The present disclosure describes methods for screening cocrystals of active agents and guests comprising the steps of contacting an active agent with a suitable liquid to form an active-agent solution; contacting the active-agent solution with a guest solution to form an interface region mixture of the solutions; and solidifying the solution mixture to form a solid; and analyzing the solid to detect the presence of cocrystals. The present disclosure further describes methods of preparing cocrystals of active agents and guests comprising the steps of contacting the active agent with a suitable liquid to form an active-agent solution; contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region; and solidifying the solution mixture in the interface region to form a cocrystal.

The present disclosure describes methods for screening cocrystals of active agents and guests using suitable liquids. By screening, what is meant is determining whether an active agent and a guest form a cocrystal under the methods described herein. In one embodiment of the disclosure, an active agent is contacted with a suitable liquid to form a composition. The active-agent/suitable liquid composition is then heated until dissolution occurs.

The solution of the active agent and the suitable liquid is combined either with a solution containing the guest alone, which would be in the form of a melt, or a solution containing the guest and the same or a different suitable liquid than that in the active-agent solution. The solutions are combined by allowing boundaries of the two solutions to come in contact with one another at the interface region between the two solutions. Mixing occurs in the interface region but not outside of it. Thus, on the active agent side of the interface, there is substantially no guest beyond the interface and, likewise, on the guest side of the interface, there is substantially no active agent beyond the interface. Where the solutions mix in the interface region, there is a gradient of concentrations ranging from pure active agent in solution to

pure guest in solution with a range of concentrations in between.

BRIEF DESCRIPTION OF DRAWINGS

Figure 1 is a schematic representation of one embodiment of the invention showing an active agent solution in contact with a guest solution in an interface region.

Figure 2 is a series of micrographs showing cocrystal screening of glutaric acid and compound 1 of Example 1.

Figure 1 illustrates an embodiment of the disclosure. In that figure, the active agent solution side has been combined with the guest solution side in the interface region. Both solutions were deposited on a slide and coverslip was placed on the slide to allow for mixing in the interface region. The figure illustrates the formation of a cocrystal which may have occurred, for instance, by cooling. In a typical experiment, the cooling procedure also solidifies the active agent solution side and the guest solution side such that much of what was previously in solution has solidified. By heat cycling the slide, it can be determined whether the solid in the center is indeed a cocrystal. If the solid is compound A, then heating the slide will show a liquid region in the interface region. Likewise, if the solid is compound B, then heating the slide will also result in a liquid in the interface region. If, however, the solid is a cocrystal of the active agent and the guest, then it will have melting properties that differ from either the active agent alone or the guest alone. Thus, heat cycling a cocrystal will yield at some points in the heat cycling a liquid on one side of the solid and at other points, a liquid on the other side of the solid.

Once the two solutions are combined into a mixture, a solidification is allowed to occur in the interface region. In one embodiment of the disclosure, solidification in the interface region occurs by cooling the interface region until a solid forms. The solid typically contains a cocrystal of the active agent and guest, the active agent alone, the guest alone, or a combination thereof. The presence of a cocrystal in the solid may be confirmed by observing eutectic formation in the interface region. Generally, a eutectic is present when the composition of a mixture of two molecular species has a minimum melting point that is lower than the melting points of the two individual molecular species.

One can determine whether eutectics occur by heat cycling the solid in the interface region. In the interface region, the mixture of the active agent and the guest causes a melting point depression effect. When the temperature is raised, the solids in the interface region melt first due to the depressed melting point. If no cocrystal has formed, then a single clear solution will be observed in the interface region. This liquid is evidence of a eutectic. If, on the other hand, a cocrystal has formed, then two separate portions of the interface regions containing eutectics will be observed, possibly at different temperatures and, therefore, at different times during a heat cycling experiment. One eutectic-containing interface region will form between the cocrystal and the active agent side and another will form in between the cocrystal and the guest side. One way to observe cocrystal presence is to view the interface region through an optical microscope equipped with polarizing filters. In such a microscope, the cocrystal will appear bright and the eutectic regions, which will only contain liquid, will appear dark.

To further analyze the cocrystal, one may use any suitable analytical technique for analyzing crystalline solids such as x-ray powder diffraction, single- crystal x-ray diffraction, Raman spectroscopy including Raman microscopy, solid- state NMR spectroscopy, and IR spectroscopy. Other analytical methods such as melting point determination, thermal gravimetric analysis, DSC, elemental analysis, and others may also provide useful information about the cocrystal. Once the cocrystal forms, a seed of the cocrystal may be used to assist in the nucleation of the cocrystal in other solidification experiments.

A suitable liquid of the disclosure is one which when combined with an active agent and heated lowers the melting point of the active agent, prevents the active agent from decomposing when heated to a temperature which, in the absence of the suitable liquid the active agent would at least partially decompose, or both.

Many active agents have relatively high melting points. For example, agents with a melting temperature of greater than about 200 ⁰ C are difficult to work with or melt on many experimental instruments. In addition, many active agents are prone to decompose when heated prior to reaching their melting point. Further, the greater the difference between the melting point values of active agents and guests, the greater the difficulty in observing eutectic formation during a Kofler contact method experiment.

A suitable liquid of the disclosure, when combined with an active agent forms a solution at a lower temperature than that of the melting point of the active agent. By varying the amount of suitable liquid used, one can also vary the temperature at which dissolution of the active agent occurs.

When selecting suitable liquids for the methods of the disclosure, it has been observed that different suitable liquids may have different properties with respect to any given active agent. One of the factors involved in selecting a suitable liquid is the temperature at which dissolution occurs. For example, it is generally inconvenient to perform the cocrystal screening experiments of the invention at temperature above about 200 ⁰ C due, for instance, to the evolution of potentially toxic fumes at such elevated temperatures. Thus, it is often valuable to have a suitable liquid/active agent combination wherein dissolution occurs at a temperature less than about 200 ⁰ C. Other factors when selecting a suitable liquid for a particular active agent is the ability of the active agent to nucleate in the suitable liquid, the growth rate of crystals of the active agent in the suitable liquid, and the quality of crystals that may grow from the suitable liquid.

The nucleation and crystallization behavior of the active agent, the guest, or both, may be affected by which suitable liquid is employed. A factor that may affect nucleation and crystallization includes the ability of the suitable liquid to accept or donate hydrogen bonds. Thus, a number of suitable liquids may be tested in any given screen for cocrystals in order to determine which promotes the preferred crystallization behavior of the active agent or guest.

Suitable liquids of the disclosure are typically organic compounds that are liquids or oils at room temperature. In one embodiment, suitable liquids have low toxicity in order to minimize the biological effects of volatile fumes that may be created during the melting process.

Examples of suitable liquids of the disclosure include but are not limited to benzyl alcohol phenethyl alcohol ethyl butyrate ethyl acetoacetate methyl benzoate ethyl benzoate anisole cyclopentanone ethyl isovalerate cymene p-anisaldehyde

1 ,1-diethoxyethane methyl propionate

2'-hydroxyacetophenone ethyl cinnamate ethyl phenylacetate ethyl salicylate gamma-valerolactone phenylethanal

2-methoxy-4-methylphenol

3-phenylpropionaldehyde

1-phenylethyl propionate ethyl 4-methoxybenzoate salicylylaldehyde

2,2'-oxybisethanol methyl salicylate p-anisaldehyde

2'-hydroxyacetophenone p-methylacetophenone ethylene glycol dimethylsulfoxide dimethyl formamide octyl alcohol

nitro-benzene benzonitrile

The active agent is the molecule whose activity is desirable. One or more active agents may be employed in a cocrystal, according to the methods of the disclosure.

Active agents may include APIs. Examples of APIs (or salts thereof) may be found, for instance, in the FDA Orange Book. Other examples of active agents include nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, or structural and electronic materials.

The active agent may be provided as a salt. One or more salts may be employed in a cocrystal, according to the methods of the disclosure. The salt may be prepared from the active agent or obtained from a commercial source. In the pharmaceutical industry, for instance, hydrochloride salts of active pharmaceutical ingredients, especially of amine APIs, are commonly used. The present cocrystals may comprise salts other than chloride salts. Examples of salts include, but are not limited to, those formed from the following acids: sulfuric acid phosphoric acid hydrobromic acid nitric acid pyrophosphoric acid methanesulfonic acid thiocyanic acid naphthalene-2-suIfonic acid

1 ,5-naphthalenedisulfonic acid cyclamic acid p-toluenesulfonic acid maleic acid

L-aspartic acid

2-hydroxy-ethanesulfonic acid glycerophosphoric acid ethanesulfonic acid

hydroiodic acid

In other aspects of the disclosure, the active agent is an anion of a salt. Cations (including cations as well as compounds that can form cations) for preparing active agents as salts include, but are not limited to, aluminum, ammonium, benzathine, calcium, diethanolamine, diethylamine, dimeglumine, disodium, lithium, lysine, magnesium, meglumine, potassium, sodium, and zinc. Among the preferred anions are acetate, L-aspartate, besylate, bicarbonate, carbonate, D-camsylate, L- camsylate, citrate, edisylate, fumarate, gluconate, hydrobromide/bromide, hydrochloride/chloride, D-lactate, L-lactate, DL-lactate, D,L-malate, L-malate, mesylate, pamoate, phosphate, succinate, sulfate, D-tartrate, L-tartrate, D,L-tartrate, meso-tartrate, benzoate, gluceptate, D-glucuronate, hybenzate, isethionate, malonate, methylsufate, 2-napsylate, nicotinate, nitrate, orotate, stearate, tosylate, acefyllinate, aceturate, aminosalicylate, ascorbate, ascorbate, borate, butyrate, camphorate, camphocarbonate, decanoate, hexanoate, cholate, cypionate, dichloroacetate, edentate, ethyl sulfate, furate, fusidate, galactarate (mucate), galacturonate, gallate, gentisate, glutamate, glutamate, glutarate, glycerophosphate, heptanoate (enanthate), hydroxybenzoate, hippurate, phenylpropionate, iodide, xinafoate, lactobionate, laurate, maleate, mandelate, methanesufonate, myristate, napadisilate, oleate, oxalate, palmitate, picrate, pivalate, propionate, pyrophosphate, salicylate, salicylsulfate, subsalicylate, subsalicylate, tannate, terephthalate, thiosalicylate, tribrophenate, valerate, valproate, adipate, 4-acetamidobenzoate, camsylate, octanoate, estolate, esylate, glycolate, thiocyanate, and undecylenate.

When a metal cation is employed as a counterion of the active agent, the interaction between the guest of a cocrystal and the cation is not a hydrogen bond but rather is an intermolecular interaction between an electron rich group such as a carbonyl and the metal cation. This interaction is often not as strong as a hydrogen bond, but is still a favorable interaction and thus can contribute to the stabilization of the cocrystal.

When the active agent is a HCI salt, one can cocrystallize the HCI salt with a neutral guest molecule. By doing this one can create solid state phases with specific properties. For instance one can make a solid comprising an active pharmaceutical ingredient having greater or lesser intrinsic solubility and/or a faster or slower dissolution rate, depending on the guest compound that is chosen.

By "guest" what is meant is the component of the cocrystal that is not the active agent of the disclosure. The guest is present in order to form the cocrystal with the active agent. It is contemplated that one or more guests may be employed in a cocrystal, according to any of the techniques of the disclosure. Accordingly, the guest is not required to have an activity of its own, although it may have some activity. In some situations, the guest may have the same activity as or an activity complementary to that of the active agent. The guest may be another active agent. For example, some guests may facilitate the therapeutic effect of an active pharmaceutical ingredient. For pharmaceutical formulations, the guest may be any pharmaceutically acceptable molecule(s) that forms a cocrystal with the API or its salt. The Registry of Toxic Effects of Chemical Substances (RTECS) database is a useful source for toxicology information, and the GRAS list contains about 2500 relevant compounds. Both sources may be used to help identify guests.

The guest may be neutral (such as benzoic acid and succinic acid in the examples below) or ionic (such as sodium benzoate or sodium succinate). Neutral guests are nonionic guests. Ionic guests are compounds or complexes having ionic bonds. General classes of guests include but are not limited to organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganics, aliphatic esters, aliphatic ketones, organic acids, aromatic esters, and aromatic ketones. The guest may be an acid that forms hydrogen bonds with the chloride (or other anion). For example, suitable guests which are acids include (but not are not limited to): ascorbic acid glucoheptonic acid sebacic acid alginic acid cyclamic acid ethane- 1 ,2-disulfonic acid

2-hydroxyethanesulfonic acid

2-oxo-glutaric acid naphthalene- 1 ,5-disulfonic acid nicotinic acid pyroglutamic acid

4-acetamidobenzoic acid

Table 1 sets forth a group of guests of the disclosure. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 1

10-camphorsulfonic acid oleic acid 10-undecylenic acid o-methylbenzoic acid 1-hydroxy-2-napthoic acid orotic acid 2,4-dihydroxybenzoic acid orthoboric acid 2,5-dihydroxybenzoic acid o-toluic acid 2-aminopropionic acid p-acetamidobenzoic acid 2-ethylbutyrinc acid palmitic acid 2-furancarboxylic acid pamoic acid 2-mercapotobenzoic acid phenoxyacetic acid 3-methylbutanoic acid phenylacetic acid phenylalanine

3phenylpropionic acid

4-aminobenzoic acid picric acid

4-aminosalicylic acid pivalic acid

4-hydroxybenzoic acid praline adipic acid p-toluenesulfonic acid alginic acid pyroglutamic acid anisic acid pyruvic add arginine salicyclic acid ascorbic acid sebacic acid asparagine serine aspartic acid sorbic acid aspirin stearic acid benzenesulfonic acid succinic acid benzoic acid sulfosalicylic acrid

4-acetamidobenzoic acid tartaric acid

TABLE 1 terephthalic acid beta-alanine thiocyanic acid camphoric acid threonine camphorsulfonic acid tiglic acid carbonic acid tryptophan cholic acid tyrosine cinnamic acid valeric acid citric acid valine cyciamic acid cyclohexanecarboxylic acid cyclohexylacetic acid cysteine diphenylacetic acid dodecylsulfonic acid ethane-1 ,2-disulfonic acid ethanesulfonic acid ethanesulfonic acid, 2-hydroxy ethylenediaminetetraacetic acid ethylsulfuric acid fu marie acid galactaric acid gallic acid gentisic acid glucoheptonic acid gluconic acid glutamic Acid glutamine glutaric acid glutaric acid, 2-oxo- glycine glycolic acid

TABLE 1 hippuric acid histidine hydroxypropline isoleucine lactobionic acid lauric acid leucine levulinic acid lysine maleic acid malic acid malonic acid mandelic acid m-methoxybenzoic acid naphthalene-1 ,5,disulfonic acid naphthalene-2-sulfonic acid n-decanoic acid niacin nicotinic acid n-tetradecanoic acid

Table 2 sets forth another group of guests of the disclosure. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 2

Name CAS #

Potassium bicarbonate 298-14-6

Potassium carbonate 584-08-7

Potassium chloride 7447.40-7

TABLE 2

Name CAS #

Potassium hydroxide 1310-58-3

Potassium metabisulfite 16731-55-8

Potassium nitrate 7757-79-1

Potassium nitrate 7758-09-0

Potassium permanganate 7722-64-7

Potassium persulfate 7727-21-1

Potassium phosphate, dibasic 2139900

Potassium Phosphate 7778-77-0 Monobasic potassium phosphate, tribasic, 7778-53-2 n-hydrate

Potassium sulfate 7778-80-5

Sodium bicarbonate 144-55-8

Sodium bisulfite 7631-90-5

Sodium borohydride 16940-66-2

Sodium carbonate 497-19-8 Sodium Carbonate Monohydrate 1486118

Sodium chloride 7647-14-5

Sodium dithionite 7775-14-6

Sodium fluoride 7681-49-4

Sodium hexamataphosphate 10124-56-8

Sodium hydroxide 1310-73-2

Sodium hypochlorite 7681-52-9

Sodium Metabisulfite 7681-57-4

Disodium metasilicate 6834-92-0 sodium monophosphate 7681-53-0

Sodium nitrate 7631-99-4

Sodium nitrite 7632-00-0 sodium hydrogen phosphate 7558-79-4

Sodium Phosphate Monobasic 7558-80-7

TABLE 2

Name CAS #

Sodium Pyrophosphate 7722-88-5

Sodium silicate 1344-09-8

Sodium Sulfate Decahydrate 7727-73-3

Sodium sulfite 7757-83-7

Sodium Thiosulfate 10102-17-7

Pentahydrate

Calcium acetate 5743-26-0

Calcium Carbonate 471-34-1

Calcium Chloride Dihydrate 10035-04-8

Calcium gluconate 299-28-5 calcium hydroxide 1305-62-0

Calcium oxide 1305-78-8

Calcium phosphate, dibasic 7757-93-9

Calcium Phosphate Monobasic 7758-23-8

Calcium sulfate 7778-18-9

Magnesium hydroxide 1309-42-8

Magnesium Sulfate 10034-99-8

Heptahydrate

Aluminum 7429-90-5

Aluminum ammonium sulfate 7784-26-1

Aluminum chloride 7446-70-0

Aluminum hydroxide 21645-51-2

Aluminum potassium sulfate, 7784-24-9 dodecahydrate

Orthoboric acid 10043-35-3 formaldehyde 50-00-0

DL-Isoleucine 443-79-8

(2S,7S)-(-)Cystine 56-89-3

DL-Alanine 302-72-7 beta-Alanine 107-95-9

TABLE 2

Name CAS #

(S)-(+)-Arginine 74-79-3

(S)-(-)-Cysteine 52-90-4

DL-Glutamic acid 617-65-2

Glycine 56-40-6

(S)-H-H istine 71-00-1

(S)-(+)-Lysine 56-87-1

DL-Methionine 59-51-8

DL-Phenlalanine 150-30-1

(S)-(-)Phenylalanine 63-91-2

D-(+)-Proline 344-25-2

(S)-(-)-Tryptophan 73-22-3

(S)-(-)-Tyrosine 60-18-4

Carvone 99-49-0

Citral 5392-40-5

Ethyl butyrate 105-54-4 lsobutyl propionate 540-42-1

Methyl butyrate 623-42-7 n-Propyl acetate 109-60-4 lsobutyl formate 542-55-2

Benzyl acetate 140-11-4

6-Methyl-5-hepten-2-one 110-93-0

Butyl acetate 123-86-4

Ethyl acetoacetate 141-97-9 lsopentyl Acetate 123-92-2

Cinnamaldehyde 104-55-2

Methyl benzoate 93-58-3

Butyl sulfide 544-40-1

Ethyl benzoate 93-89-0

2,4-Hexadienoic acid, 24634-61-5 potassium salt, (E ₁ E)-

TABLE 2

Name CAS #

Potassium bitartrate 868-14-4

Laurie acid 143-07-7

Benzyl benzoate 120-51-4

Picric acid 88-89-1

Benzoyl peroxide 94-36-0

Palmitic acid 57-10-3

Dibutyl phthalate 84-74-2

Stearic acid 57-11-4

Succinic anhydride 108-30-5

Diethylenetriamine 111 -40-0

Diethanolamine 111 -42-2

Benzaldehyde 100-52-7

Phenethylamine 64-04-0

Salicylylaldehyde 90-02-8

Sodium benzoate 532-32-1

Cinnamic acid 621-82-9

Triethanolamine 102-71-6

L-(+)-Tartaric Acid 87-69-4

Eugenol 97-53-0

D-mannitol 69-65-8

Butyl paraben 94-26-8

Benzoin 119-53-9

Diethyl phthalate 84-66-2

Oleic acid 112-80-1

Sodium lactate 72-17-3

Indole 120-72-9 etbyl lactate 97-64-3 quinoline 91-22-5

Thymol 89-83-8

Methyl anthranilate 134-20-3

TABLE 2

Name CAS #

Methyl salicylate 119-36-8

Diethyl malonate 105-53-3

Citric acid 77-92-9

Sodium dodecyl sulfate 151-21-3

Morpholine 110-91-8

Furfural 98-01-1

Niacin 59-67-6

Choline chloride 67-48-1

L-Menthol 2216-51-5

Meso-inositol 87-89-8 ethylenediaminetetraacetic 60-00-4 acid

EDTA, calcium derivative, 62-33-9 disodium salt

Calcium pantothemate 137-08-6

Riboflavin 83-88-5

Zinc carbonate 3486-35-9

Amyl alcohol 71-41-0

Mineral oil 8012-95-1

Triton(R) X-100 9002-93-1

Acetaldehyde 75-07-0

Acetic Acid 64-19-7

Acetone 67-64-1

Acetophenone 98-86-2

4-Aminobenzoic acid 150-13-0

Anisole 100-66-3

Vitamin C 50-81-7

Benzoic Acid 65-85-0

Biphenyl 92-52-4

2-Methyl-1 propanol 78-83-1

TABLE 2

Name CAS # n-Butanol 71-36-3 n-Butylamine 109-73-9 ethyl acetate 141-78-6

Caffeine 58-08-2

Chloroacetic Acid 79-11-8

Dichloroacetic Acid 79-43-6

Diethylamine 109-89-7

Ethanol Amine 141-43-5 n-Butyric Acid 107-92-6

Ethylenediamine 107-15-3

Formic acid 64-18-6 n-Hexanol 111-27-3

Methanol 67-56-1

Methyl Acetate 79-20-9

Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4 p-Cresol 106-44-5

Phenol 108-95-2 n-Propanol 71-23-8

Propionic Acid 79-09-4

Salicylic acid 69-72-7

Sucrose 57-50-1

Vanillin 121-33-5

Vitamin E 59-02-9

Potassium citrate, monohydrate 1534146 p-toluenesulfonic acid 6192-52-5 monohydrate

D-(+)-MaItose 69-79-4

Tetrasodium 64-02-8 ethylenediaminetetraacetate

TABLE 2

Name CAS #

Saccharin sodium 128-44-9

Sodium Acetate Tri hydrate 6131-90-4

Quinine sulfate, dihydrate 6119-70-6

Sulfosalicylic acid, dihydrate 5965-83-3

L-(+)-Arginine 1119-34-2 monohydrochloride

Procaine hydrochloride 51-05-8

Pyridoxine Hydrochloride 58-56-0

Thiamine hydrochloride 67-03-8

Propionaldehyde 123-38-6

Urea 57-13-6

2-Propanol 67-63-0

Pyrrole 109-97-7

Sodium formate 141-53-7

Pyrrolidine 123-75-1

Methyl ethyl ketone 78-93-3

Ethyl formate 109-94-4

Propylene glycol 57-55-6

Thiourea 62-56-6

Ammonium acetate 631-61-8

Benzene 71-43-2

Sodium acetate 127-09-3

Cyclopentanone 120-92-3

Cyclohexane 110-82-7 piperidine 110-89-4

2-Pentanone 107-87-9 hexane 110-54-3 lsoamyl Alcohol 123-51-3

Lactic acid 50-21-5

2-Ethoxyethanol 110-80-5

TABLE 2

Name CAS #

Propionic acid, sodium salt 137-40-6

Potassium acetate 127-08-2 cyclohexyl amine 108-91-8 methyl methacrylate 80-62-6 methyl isobutyl ketone 108-10-1

Acetic anhydride 108-24-7 lsopropyl Acetate 108-21-4

2,2'-Oxybisethanol 111-46-6

Benzyl alcohol 100-51-6

Resorcinol 108-46-3

2-Butoxy ethanol 111-76-2

Cumene 98-82-8

2-Amino-2-(hydroxymethyl)-1 ,3- 77-86-1 propanediol

Phenethyl alcohol 60-12-8

2-Ethyl-1-hexanol 104-76-7

2-Octanol 123-96-6

2-(2-Ethoxyethoxy) ethanol 111-90-0

2,6-(Dimethyl-4-heptanone 108-83-8

Benzophenone 119-61-9

D-(-)-Fructose 57-48-7

D-Glucose 50-99-7

D-Ribose 50-69-1

D-(+)-Xylose 58-86-6

Pectin sugar 5328-37-0

D-(+)-Lactose 63-42-3

Camphene 79-92-5

Isoquinoline 119-65-3

2,4-Dimethylphenol 105-67-9

2,5-Dimethylphenol 95-87-4

TABLE 2

Name CAS #

2,6-Dimethylphenol 576-26-1

Methanesulfonic Acid 75-75-2 o-Methoxybenzoic Acid 579-75-9

Saccharin 81-07-2

Thiazole 288-47-1

Trifluoromethanesulfonic Acid 1493-13-6

Trimethylamine 75-50-3

Coumarin 91-64-5

Dimethylamine 124-40-3

Ethyl Alcohol 64-17-5

Butyl benzyl phthalate 85-68-7

2,6-dimethylpyrazine 108-50-9 taurocholic acid 81-24-3 geraniol 106-24-1

Iinalool 78-70-6 ethyl isovalerate 108-64-5 ethyl 2-methylbutyrate 7452-79-1

1 -octen-3-ol 3391-86-4 ethyl 2-trans-4-cis- 3025-30-7 decadienoate

Dihydromyrcenol 18479-58-8 citronellal 106-23-0 linalyl acetate 115-95-7

8-mercapto-p-menthan-3-one 38462-22-5

Ammonium citrate 3012-65-5

Ammonium bicarbonate 1066-33-7

Ammonium chloride 12125-02-9

Ammonium hydroxide 1336-21-6

Ammonium persulfate 7727-54-0

Ammonium phosphate, dibasic 7783-28-0

TABLE 2

Name CAS #

Ammonium Phosphate 7722-76-1

Monobasic

Ammonium sulfate 7783-20-2

Ammonium sulfide 12135-76-1

Hydrazine 302-01-2

Nitric acid 7697-37-2 phosphoric acid 7664-38-2

Phosphorus oxychloride 10025-87-3

Hydriodic acid 10034-85-2

Hydrobromic acid 10035-10-6

Huydrochloric acid 7647-01-0 hydrogen peroxide 7722-84-1

Periodic Acid 10450-60-9

Sulfamic acid 5329-14-6

Sulfuric acid 7664-93-9

Sulfurous acid 7782-99-2

Dexpanthenol 81-13-0

4-oxoisophorone 1125-21-9

Copper(ll) sulfate 7758-98-7 ferric chloride 7705-08-0

Ferric oxide 1309-37-1 ferric sulfate 10028-22-5

Iron (II) Sulfate Heptahydrate 7782-63-0

Iron 7439-89-6

Manganese (II) Sulfate 10034-96-5

Monohydrate

Nickel 7440-02-0

Titanium dioxide 13463-67-7

Zinc chloride 7646-85-7

Zinc oxide 1314-13-2

TABLE 2

Name CAS #

1 , 1 '-Azobisformamide 123-77-3

1 ,3-Butanediol 107-88-0

1-Methylnaphtalene 90-12-0

2,6-Di-tert-Butyl-p-Cresol 128-37-0

2,6-Dimethylpyridine 108-48-5

Disodium 138-93-2 cyanodithiomidocarbonate 3-Methyl-2-Cyclopentene-2-ol- 80-71 -7 one

6-Methylcoumarin 92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2 alpha-Terpinene 99-86-5

Benzenesulfonic Acid 98-11 -3

Benzothiazole 95-16-9 borates, tetrasodium salts 1330-43-4

Butyl butyrate 109-21-7

Butyl Mercaptan 109-79-5 Butyraldehyde , 123-72-8

Capasaicin 404-86-4

Chloromethyl Methyl Ether 107-30-2

Cymene 99-87-6

Diallyl Disulfide 2179-57-9

Diethylaminoethanol 100-37-8 dimethyldisulfide 624-92-0

Dimethyl Succinate 106-65-0

Dimethyl Sulfate 77-78-1

Dimethyl Sulfide 75-18-3

Dipropyl Disulfide 629-19-6

Dipropyl Ketone 123-19-3

TABLE 2

Name CAS #

Ethyl Acrylate 140-88-5

Ethyl Butyl Ketone 106-35-4

Ethyl Propionate 105-37-3

Furfuryl Alcohol 98-00-0 gamnma-Butyrolactone 96-48-0

Glutaraldehyde 111-30-8 gylcerin 56-81-5

Glycolic Acid 79-14-1 lsobutyl Acetate 110-19-0 lsobutyl lsobutyrate 97-85-8 lsobutyraldehyde 78-84-2 lsoheptanol 543.49-7 lsophorone 78-59-1 lsopropyl Mercaptan 75-33-2

Methyl isobutenyl ketone 141-79-7

Methyl n-amyl ketone 110-43-0 methyl acrylate 96-33-3

Methyl lsobutyrate 547-63-7

Methyl Mercaptan 74-93-1

N,N-Dimethylethanolamine 108-01-0 n-Butyl Lactate 138-22-7 n-Hexyl Acetate 142-92-7 n-Valeraldehyde 110-62-3

Nitrous Oxide 10024-97-2 p-Anisaldehyde 123-11-5

2-Methylcyclohexanone 583-60-8

Octanoic Acid 124-07-2

Oxalic Acid 144-62-7

Phenyl ether 101-84-8

Phenylmercaptan 108-98-5

TABLE 2

Name CAS #

Propargyl Alcohol 107-19-7

Propyl paraben 94-13-3 sec-Butyl Alcohol 78-92-2

Sodium Gluconate 527-07-1

Sodium Tripolyphosphate 7758-29-4

Tetrahydro-2-furanmethanol 97-99-4

Valeric Acid 109-52-4

3,4-xylenol 95-65-8

3-hexanol 623-37-0

3-methyl-1 -pentanol 589-35-5

1 ,1-diethoxyethane 105-57-7

Aluminum Sulfate 10043-01-3 ammonium sulfite 10196-04-0 amyl butyrate 540-18-1 borneol 507-70-0 butyl formate 592-84-7 calcium peroxide 1305-79-9 n-Hexanoic Acid 142-62-1 cyclohexyl acetate 622-45-7 diacetyl 431-03-8 dimethyl carbonate 616-38-6 ethyl butyraldehyde 97-96-1

Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 ethyl nitrite 109-95-5 fumaric acid 110-17-8 hexaldehyde 66-25-1 isobutyric acid 79-31-2 methyl isovalerate 556-24-1 methyl propionate 554-12-1

TABLE 2

Name CAS # methyl valeraldehyde 123-15-9 nitrosyl chloride 2696-92-6 octafluorocyclobutane 115-25-3 peroxyacetic acid 79-21-0 propyl formate 110-74-7 propyl mercaptan 107-03-9

Sodium aluminate 1302-42-7 sodium chlorite 7758-19-2

Terephthalic Acid 100-21-0 allyl isothiocyanate 57-06-7

Vitamin B1 59-43-8

Valproic acid 99-66-1

Ethoxyquin 91-53-2 n-Amyl Ethyl Ketone 106-68-3

Nabam 142-59-6

Sodium sulfide 1313-82-2

Thiocyanic acid 463-56-9

2-Methyl-5-(1-methylethenyl)- 2244-16-8

2-cyclohexene-1 -one

4-(2,6,6-Trimethyl-2- 127-41-3 cyclohexen-1 -yl)-3-buten-2-one

4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1 -yl)-3-buten-2-one lsoamyl propionate 105-68-0

3-Methylbutanoic acid 503-74-2

L-Menthone 14073-97-3

4-Ethylphenol 123-07-9 o-cresol 95-48-7 dimethyl-Carbamodithioic acid, 128-04-1 sodium salt

TABLE 2

Name CAS #

Anethole 104-46-1

Dimethyl terephthalate 120-61-6 propyl gallate 121-79-9

L-Ascorbic Acid Sodium Salt 134-03-2

4-Hexylresorcinol 136-77-6

Estragole 140-67-0

L-monosodium glutamate 142-47-2

Malonaldehyde, sodium salt 24382-04-5

Butylated hydroxyanisόle 25013-16-5 allyl 3-methylbutyrate 2835-39-4

DL-monosodium glutamate 32221-81-1

3-Acetyl-6-methyl-2,4- 520-45-6 pyrandione

L-Glutamic Acid 56-86-0

DL-alpha-tocopheryl acetate 58-95-7

D-limonene 5989-27-5

Calcium Acetate 62-54-4

Erythorbic Acid Monosodium 6381-77-7

Salt

Ethyl methylphenylglycidate 77-83-8

2,4,6-Trinitro-1 ,3-dimethyl-5- 81-15-2 tert-butylbenzene

Dimethoxane 828-00-2

3,5-Di-tert--butyl-4- 88-26-6 hydroxybenzyl alcohol

6-Methylquinoline 91-62-3 alpha-Methylbenzyl alcohol 98-85-1

Nicotinamide 98-92-0

3,4-Dihydrocoumarin 119-84-6

Geranyl Acetate 105-87-3

TABLE 2

Name CAS #

Sodium (2-Ethylhexyl)Alcohol 126-92-1

Sulfate

Cyclohexanol, 5-methyl-2~(1- 89-78-1 methylethyl)-,

(1 alpha,2beta,5alpha)~

(+)-Camphor 464-49-3

(1 S)-(-)-alpha-Pinene 7785-26-4

1 ,3-Dihydroxy-5-methylbenzent€ ; 504-15-4

1 ,5-Naphthalenedisulfonic Acid 1655-29-4

Disodium Salt

1-Hydroxy-2-naphthoic Acid 86-48-6

1-Penten-3-ol 616-25-1

1 -Phenyl-1 -propanol 93-54-9

10-Undecylenic Acid 112-38-9

2'-Hydroxyacetophenone 118-93-4

2,4-Dihydroxybenzoic Acid 89-86-1

2-Acetylfuran 1192-62-7

2-Furancarboxylic Acid 88-14-2

2-lsopropylphenol 88-69-7

2-Ketoglutaric Acid 328-50-7

2-Ketovaline 759-05-7

2-n-Propylphenol 644-35-9

2-Naphthalenethiol 91-60-1

2-Phenyl-1 -propanol 1123-85-9

3,3'-Thiodipropionic Acid 111-17-1

3,5,5-Trimethylhexanal 5435-64-3

3-Phenyl-1 -propanol 122-97-4

3-Phenylpropionic Acid 501-52-0

4-Aminosalicylic Acid 65-49-6 -Ethoxyphenol 622-62-8

TABLE 2

Name CAS #

4-Hydroxybenzoic Acid 99-96-7

4-Phenyl-2-butanol 2344-70-9

4-tert-Octylphenol 140-66-9

AIIyI Cinnamate 1866-31-5

Ally Mercaptan 870-23-5 alpha-L-Rhamnose 3615-41-6

Alpha-Terpineol 98-55-5

Anisic Acid 100-09-4

Benzalacetone 122-57-6

Benzaldehyde Dimethylacetal 1125-88-8

Benzyl Ether 103-50-4

Benzyl Formate 104-57-4

Benzyl Mercaptan 100-53-8

Benzyl Salicylate 118-58-1

Calcium Citrate 813-94-5

Calcium Glycerophosphate 27214-00-2

Calcium Hypophosphite 7789-79-9

Calcium lodate 7789-80-2

Propanoic acid, 2-hydroxy-, 814-80-2 calcium salt (2:1 )

Calcium Phosphate Tribasic 7758-87-4

Calcium Propionate 4075-81-4

Calcium Pyrophosphate 7790-76-3

Cholic Acid 81-25-4

Choline 123-41-1

Choline Bitartrate 87-67-2 trana-Cinnamic Aldehyde 14371-10-9

Cinnamyl Alcohol 104-54-1

Citronellol 106-22-9

Copper(l)lodide 7681-65-4

TABLE 2

Name CAS #

D~(+)~Glucono-1 ,5-lactone 90-80-2

D-(-)-Tartaric Acid 147-71-7

D-lsoascorbic Acid 89-65-6

D-Tyrosine 556-02-5

Sodium dehydroacetate 4418-26-2

Deoxycholic Acid 83-44-3

Dibenzyl Ketone 102-04-5

Diethyl L-(+)-Tartrate 87-91-2

Diethyl Succinate 123-25-1

Dimethylacetal 534-15-6

DL-Cystine 923-32-0

DL-Proline 609-36-9

DL-Tartaric Acid 133-37-9

DL-Tyrosine 556-03-6

DL-Valine 516-06-3

Enanthoic Acid 111-14-8

Erythorbic Acid Sodium Salt 7378-23-6

Ethyl 2-Aminobenzoate 87-25-2

Ethyl Cinnamate 103-36-6

Ethyl n-Valerate 539-82-2

Ethyl Phenylacetate 101-97-3

Ethyl Salicylate 118-61-6

Ethyl Sulfide 352-93-2

Ethyl Vanillin 121-32-4

Ethylene Mercaptan 540-63-6

Famesene 502-61-4

Folic acid 59-30-3 gamma-Nonanolactone 104-61-0 gamma-Valerolactone 108-29-2

Gluconic Acid 526-95-4

TABLE 2

Name CAS #

Gluconic Acid Potassium Salt 299-27-4

Glutaric Acid 110-94-1

Guanosine-5'-monophosphate, 1333479 disodium salt

Hθliotropine 120-57-0

Hippuric Acid 495-69-2

Hydroquinone Dimethyl Ether 150-78-7 lnosine-5'-monophosphate 4691-65-0

Sodium Salt iso-Amyl Mercaptan 541-31-1 lsoamyl Salicylate 87-20-7 iso-butyl n-Hexanoate 105-79-3 isovaleraldehyde 590-86-3 lsoamyl Benzoate 94-46-2 lsoamyl Formate 110-45-2 lsoamyl n-Butyrate 106-27-4 lsoamylamine 107-85-7 lsobutyl n-Butyrate 539-90-2 lsocaproic Acid 646-07-1 lsoeugenol 97-54-1 lsopropyl Benzoate 939-48-0 lsopropyl Formate 625-55-8 lsopropyl N-Butyrate 638-11-9 lsopropyl Propionate 637-78-5 isobutyl Mercaptan 513-44-0

L-(+)-lsoleucine 73-32-5

L-(-)-Apple Acid 97-67-6

L-2-Aminopropionic Acid 56-41-7

L-Aspartic acid 56-84-8

L-Camitine 541-15-1

TABLE 2

Name CAS #

L-Cysteine Hydrochloride 52-89-1

L-Glutamic Acid Hydrochloride 138-15-8

L-Glutamine 56-85-9

L-Hydroxyproline 51-35-4

L-Proline 147-85-3

L-Serine 56-45-1

L-Threonine 72-19-5

L-Valine 72-18-4

N-Acetylglycine 543-24-8 n-Amyl Formate 638-49-3 n-Amyl n-Caproate 540-07-8 n-Butyl n-Caproate 626-82-4 n-Butyl Propionate 590-01-2 n-Butyl Salicylate 2052-14-4 n-Decanoic Acid 334-48-5 n-Hexyl Mercaptan 111-31-9 n-Proply Benzoate 2315-68-6 n-Propyl lsobutyrate 644-49-5 n-Tetradecanoic Acid 544_63-8

Nitrilotriacetic Acid 5064-31-3

Trisodium Salt o-Tolunethiol 137-06-4

Orotic Acid 65-86-1 p-Acetamidobenzoic Acid 556-08-1 p-Anise Alcohol 105-13-5

Phenoxyacetic Acid 122-59-8

Phenyl Acetate 122-79-2

Piperine 94-62-2

Pivalic Acid 75-98-9

Potassium Benzoate 528-25-2

TABLE 2

Name CAS #

Potassium Diphosphate 7320-34-5

Potassim Hypophosphite 7782-87-8

Potassium Metaphosphate 7790-53-6

Potassium Sulfite 10117-38-1

Quinine Hydrochloride 130-89-2 sec-Amyl Alcohol 6032-29-7

Sodium D-Pantothenate 867-81-2

Di(2-ethylhexyl) sulfosuccinic 577-11-7 acid, sodium salt

Sodium Sorbate 7757-81-5

Succinic acid, disodium salt 150-90-3

Sodium Taurocholate 145-42-6

Taurine 107-35-7

Thiamine Nitrate 532-43-4

Thioanisole 100-68-5

Tiglic Acid 80-59-1

Tri-n-butyrin 60-01-5

Triacetin 102-76-1

Trisodium Citrate 68-04-2

Veratraldehyde 120-14-9

Veratrole 91-16-7

Vitamin P 520-26-3

Vitamin U Chloride 582174

L-Methionine 63-68-3

2-Chloro-1-propanol 78-89-7

2-Ethylbutyric acid 88-09-5

2-Methylbutyraldehyde 96-17-3

2-Methyl-5-ethylpyridine 104-90-5 n-propyl butyrate 105-66-8

Ethyl caprylate 106-32-1

TABLE 2

Name CAS #

Propyl propionate 106-36-5

2-Methylpyrazine 109-08-0

3,3,5-Trimethyl-1 -cyclohexanol 116-02-9

Ethyl caproate 123-66-0 o-methoxybenzaldehyde 135-02-4

2,4-Hexadienal 142-83-6

3-Hexanone 589-38-8

3-Methyl-2-butanol 598-75-4

Methyl isopropenyl ketone 814-78-8

3-Methyl-2-butanethiol 2084-18-6

3,5,5-Trimethylhexanol 3452-97-9

Methylglyoxal 78-98-8

Malonaldehyde 542-78-9

1 ,4-Dithiane 505-29-3

Amylcinnamaldehyde 122-40-7

Benzyl cinnamate 103-41-3 tert-Butylhydroquinone 1948-33-0

Fusidic Acid Sodium Salt 751-94-0

Hydroxycitronellal 107-75-5

Musk ketone 81-14-1

L-Asparagine 70-47-3 phenethyl acetate 103-45-7

Riboflavin 5-Phosphate 146-17-8

Potassium Sodium Tartrate 304-59-6

Galactaric acid 526-99-8

Sodium Tartrate 868-18-8

Trisodium phosphate 7601-54-9

Disodium Pytophosphate 7758-16-9

Magnesium chloride 7786-30-3

Sodium Polymethacrylate 54193-36-1

TABLE 2

Name CAS # propiophenone 93-55-0

2-ethylhexanoic acid 149-57-5

3,7,7-trimethyl bicyclohep-3- 13466-78-9 ene

2,6-dimethyl-4-heptanol 108-82-7

5-isopropyI-2-methyl-phenol 499-75-2

L-Bomyl acetate 5655-61-8 caryophyllene 87-44-5 hydroxymethylpyrone 118-71-8 neosperidin dihydrochalcone 20702-77-6

2,2-Dibromo-3- 10222-01-2 nitrilopropionamide

Xylitol 87-99-0

Sulfosalicylic acid 97-05-2

Riboflavin 5'-(dihydrogen 130-40-5 phosphate), monosodium salt

Ethylenediaminetetraacetic 139-33-3 acid, disodium salt

Gallic acid 149-91-7

Carbonic acid 463-79-6

Potassium carbonate, 6381-79-9 sesquihydrate

Magnesium phosphate tribasic 7757-87-1 diallyl sulfide 592-88-1 ethyl 4-oxopentanoate 539-88-8 methyl caproate 106-70-7 isopropyl isobutyrate 617-50-5 diethyl hydroxybutanedioate 2065419 propyl isopentanoate 557-00-6 benzyl ethyl ether 539-30-0

TABLE 2

Name CAS # isobutyl isopentanoate 589-59-3 propyl hexanoate 626-77-7

4-methylquinoline 491-35-0 methyl cinnamate 103-26-4 cumic alcohol 536-60-7 thujone 471-15-8 dihydrocarveol 619-01-2 fenchyl alcohol 1632-73-1

Nerol 106-25-2 isopentyl isopentanoate 659-70-1 methyleugenol 93-15-2 methyl 2-naphtyl ketone 93-08-3 diphenyldisulfide 882-33-7 citronellyl acetate 150-84-5 menthyl acetate 89-48-5 menthyl isovalerate 16409-46-4

5-Ethyl-3-hydroxy-4-methyl- 698-10-2

2(5H)-furanone malic acid 6915-15-7

3-methylbutanoic acid butyl 109-19-3 ester

3-phenyloxiranecarboxylic acid 121-39-1 ethyl ester

1 ,2-Benzisothiazol-3(2H)-one 6381-61-9

1 ,1-dioxide, ammonium salt

1 -methyl-4-(1 -methyl ethyl )- 99-85-4

1 ,4-Cyclohexadiene

3-mercapto-2-Butanol 54812-86-1

(1 R)-2,6,6- 7785-70-8 trimethylbicyclo[3.1.1 ]hept-2-

TABLE 2

Name CAS # ene

(1 S)-6,6-dimethyl-2- 18172-67-3 methylenebicyclo[3.1.1]heptane

1-methyl-4-)1- 586-62-9 methylethylidene)cyclohexene

1-(3-pyridinyl)ethanone 350-03-8

1-pyrazinylethanone 22047-25-2

1-(2-furyl)-2-propanone 6975-60-6

1-Penten-3-one 1629-58-9

2,3-pentanedione 600-14-6

2,5-dimethyIpyrazine 123-32-0

2-isobutyl-3-methoxypyrazine 24683-00-9

4-methyl-2,3-pentanedione 7493-58-5

5-methylfurfural 620-02-0

Dimethyltrisulfide 3658-80-8 fu rf u ryl acetate 623-17-6 furfurylmethylether 13679-46-4 terpinen-4-ol 562-74-3

Calcium sorbate 7492-55-9

Potassium lactate 996-31-6

1 -Hydroxyethylidene-1 ,1 - 2809-21-4 diphosphonic acid

L-glutamic acid monopotassium 19473-49-5 salt

3-methyl-2-buten-1-ol 556-82-1 phenylethanal 122-78-1

4'-Methoxyacetophenone 100-06-1

L-borneol 464-45-9

2,4-Hexadien-i-ol 111-28-4

D-Fenchone 4695-62-9

TABLE 2

Name CAS #

3-Phenylpropyl formate 104-64-3

Cinnamyl formate 104-65-4

D-galacturonate 685-73-4

D-glucuronate 1700908

5 ¹ IMP 131-99-7

1 -Methoxy-4-methylbenzene 104-93-8

2-Methylbutanoic acid 116-53-0

2,4,6-Tribromophenol 118-79-6

3-Ethyl pyridine 536-78-7

Zinc acetate 557-34-6

Methyl pentanoate 624-24-8

Methylthioethane 624-89-5

3-Penten-2-one 625-33-2

GIyocholic acid 475-31-0 m-Methoxybenzoic acid 586-38-9 alpha-Hydroxypropionic acid 598-82-3

Methyl 2-furoate 611-13-2

2-FurancarboxyIic acid, propyl 615-10-1 ester

Benzylacetoscetic acid, ethyl 620-79-1 ester

2,5-Dimethyl pyrrole 625-84-3

4-methyl-1 ,1 '-biphenyl 644-08-6 pisopropylacetophenone 645-13-6

4-methyl-thiazole 693-95-8 gamma-Decalactone 706-14-9

2-aceltylpyrrole 1072-83-9

2-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-4

Methyl 4-phenylbutyrate 2046-17-5

TABLE 2

Name CAS #

2,3,6-trimethyl-phenol 2416-94-6

2-Methoxypyrazine 3149-28-8

2-Ethylfuran 3208-16-0

2,3-dimethyl-pyrazine 5910-89-4

Thiophenethiol 7774-74-5 o-Tolyl isobutyrate 36438-54-7 cis-3-Hexenyl pyruvate 68133-76-6 cis-3-Hexenyl cis-3-hexenoate 61444-38-0 trans-2-Hexenyl isovalerate 68698-59-9 trans-2-Hexenyl formate 53398-78-0 trans-2-Hexenyl valerate 56922-74-8

1-Octen-3-yl butyrate 16491-54-6

Methyl 4-(methylthio)butyrate 53053-51-3

2,4-Octadien-1-ol 18409-20-6

2,4-Nonadien-1-ol 62488-56-6

2,4-Decadien-1-ol 18409-21-7

(e,z)-2,6-Nonadienyl acetate 68555-65-7

3-Hexenal 4440-65-7

Tetrahydro-2-furanmethanoI 637-64-9 acetate

Methyl benzaldehyde 1334-78-7

Dodecylsulfonic acid 1510-16-3

Methylethyl disulfide 4253-89-8

Farnesol 4602-84-0

Thiobenzoic acid, S-methyl 5925-68-8 ester

Hexyl benzoate 6789-88-4

2,5-Diethyltetrahydrofuran 41239-48-9

Zinc hydrosulfite 7779-86-4

(2R,3S)-Tartaric Acid 147-73-9

TABLE 2

Name CAS #

Ethylsufuric acid 540-82-9

1 ,2,2-TrimθthyM ,3- 5394-83-2 cyclopentanedicarboxylic acid

2-Methyl-3-buten-2-ol 115-18-4 trans-2-Hexenal 6728-26-3

4-Hexen-3-one 2497-21-4

1-Hexen-3-ol 4798-44-1

2-Methyl-1-butanethiol 1878-18-8

4-Methylcyclohexanone 589-92-4

3-Heptanol 589-82-2 o-methylanisole 578-58-5 trans-2-octenal 2363-89-5

2,3,4-Trimethyl-3-pentanol 3054-92-0

Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophernone 122-00-9 o-aminoacetophenone 551-93-9

4-Propylphenol 645-56-7

2,4-Dimethylanisole 6738-23-4

Benzyl methyl sulfide 766-92-7

Methyl penylacetate 101-41-7

4-Ethoxybenzaldehyde 10031-82-0 p-tolyl acetate 140-39-6

2,6-Dimethoxyphenol 91-10-1 lsoborneol 124-76-5

Methyl 2-methoxybenzoate 606-45-1

Phenylacetaldehyde dimethyl 101-48-4 acetal

3-Phenylpropyl acetate 122-72-5

Ethyl 3-phenylpropionate 2021-28-5

TABLE 2

Name CAS #

Benzyl butyrate 103-37-7

Anisyl acetate 104-21-2 lsobutyl phenylacetate 102-13-6 p-vinylphenol 2628-17-3 o-tolyl acetate 533-18-6

2,5-Dihydroxybenzoic acid 490-79-9 o-methoxyphenyl acetate 613-70-7

Lactobionic acid 96-82-2

Magnesium hydrogen 7782-75-4 phosphate tri hydrate

Iberverin 505-79-3 alpha-methylcinnamaldehyde 101-39-3 benzyl phenylacetate 102-16-9

1 ,3-dimercaptopropane 109-80-8 p-cymen-8-ol 1197-01-9 phenethyl antranilate 133-18-6 trihydroxybutyrophenone 1421-63-2 o-methoxycinnamaldehyde 1504-74-1

3-propylidene phthalide 17369-59-4 trans,trans-2,4-decadienal 25152-84-5 piperonyl acetate 326-61-4

2,3-hexanedione 3848-24-6 isopropyl phenylacetate 4861-85-2 ethyl 3-hydroxybutyrate 5405-41-4 furfural acetone 623-15-4 beta-(2-furyl)acrolein 623-30-3 linalyl anthranilate 7149-26-0 citral diethyl acetal 7492-66-2 allyl anthranilate 7493-63-2

TABLE 2

Name CAS # acetyl tributyl citrate 77-90-7 butyl anthranilate 7756-96-9 cyclohexyl anthranilate 7779-16-0 isoamyl cinnamate 7779-65-9 isobutyl anthranilate 7779-77-3 carvyl acetate 97-42-7 carveol 99-48-9

3-(Methylthio)propionaldehyde 3268-49-3

Alpha-damascone 43052-87-5

Dimethyldicarbonate 4525-33-1

Procaine 59-46-1

5-hydroxy-6-methyl-3,4- 65-23-6 pyridinedimethanol

2-methoxy-Naphthalene 93-04-9

Methyl nicotinate 93-60-7

Ethyl benzoylacetate 94-02-0

Phenethyl benzoate 94-47-3

2-methyl-pentanoic acid 97-61-0

Cyclohexanecarboxylic acid 98-89-5

Methyl b-phenylpropionate 103-25-3

Benzyl 3-methyl butanoate 103-38-8

NaphthaIene-2-suIfonic acid 120-18-3

Methyl 4-methoxybenzoate 121-98-2

3-Phenylprop-2-enyl cinnamate 122-69-0

7-methyl-3-methylene-1 ,6- 123-35-3

Octadiene

Levulinic acid 123-76-2

2-Mercaptobenzoic acid 147-93-3 m-Dimethoxybenzene 151-10-0

3-butyl-1 (3H)-isobenzofuranone 6066-49-5

TABLE 2

Name CAS #

5-Methylquinoxaline 13708-12-8

2-Ethyl Pyrazine 13925-00-3 trimethyl-pyrazine 14667-55-1

2-ethyl-3-methyl-pyrazine 15707-23-0

2,3-diethyl-pyrazine 15707-24-1

2,3-diethyl-5-methyl-pyrazine 18138-04-0

2-Methylthiopyrazine 21948-70-9

5-Methyl-3H-furan-2-one 591-12-8 cis-3-Hexen-1-ol 928-96-1

3,7-Dimethyl-1 ,3,6-octatriene 13877-91-3 calcium cyclamate 139-06-0 aconitic acid 499-12-7

2-Dehydrolinalool 29171-20-8

2-Mercaptopropionic acid 79-42-5

3-Methyl-2-butenal 107-86-8

Allylacetic acid 591-80-0

AIIyI cyclohexylacetate 4728-82-9

AIIyI cyclohexylpropionate 2705-87-5

AIIyI phenoxyacetate 7493-74-5

AIIyI phenylacetate 1797-74-6

AIIyI alpha-ionone 79-78-7

Butyl butyrolactate 7492-70-8

Cinnamyl isobutyrate 103-59-3

Cinnamyl propionate 103-56-0

Dibenzyl disulfide 150-60-7 lsobornyl acetate 125-12-2

Methyl heptyne carbonate 111-12-6

Triethyl citrate 77-93-0 gamma-Undecalactone 104-67-.6 alpha-Amylcinnamyl alcohol 101-85-9

TABLE 2

Name CAS #

1 ,3,4,6,7,8-Hexahydro- 1222-05-5

4,6,6,7,8,8-hexanmethyl cyclopenta[g] [2]benzopyran

2-Ethylbutyl acetate 10031-87-5

Triphosphoric acid, 13845-36-8 pentapotassium salt

L-(+)-l_actic acid 79-33-4

Mannitol 87-78-5

2-Methoxy-4-methylphenol 93-51-6

1 ,2,3-Propanetricarboxylic acid, 144-33-2

2-hydroxy-, disodium salt

Ethanesulfonic acid, 2-hydroxy-, 1562-00-1 monosodium salt

2-Methoxy-4-propylphenol 2785-87-7

3,7-Dimethyl-3-octanol 78-69-3

2-Pentyl furan 3777-69-3

Butanoic acid, 3-oxo-, butyl 591-60-6 ester

4-(4-Hydroxy-4-methyl pentyl)-3- 31906-04-4 cyclohexene-1 -carboxaldehyde

Methyl 3-oxo-2- 24851-98-7 pentylcyclopentanescetate

Naphthalene, 2-(2- 2173-57-1 methylpropoxy)-

Perillol 536-59-4

2-Acetyl-1 -methylpyrrole 932-16-1

4-Allyl-2,6-dimethoxyphenol 6627-88-9

Butyl levulinate 2052-15-5

D-(+)-Camphoric acid 124-83-4

D(+)-10-Camphorsulfonic acid 3144-16-9

TABLE 2

Name CAS #

L-(-)-Carvone 6485-40-1

(-)-Carvyl propionate 97-45-0

(-)-Caryophyllene oxide 1139-30-6

Cyclohexylacetic acid 5292-21-7

3-Cyclopentylpropionic acid 140-77-2

(-)-Dihydrocarvyl acetate 20777-49-5

3,3-Dimethylacrylic acid 541-47-9

2,4-Dimethylbenzaldehyde 15764-16-6

1 ,4-Dithiane-2,5-diol 40018-26-6

Ethanesulfonic acid 594-45-6

Ethyl butyrylacetate 3249-68-1

Ethyl (methylthio) acetate 4455-13-4

Ethyl pyruvate 617-35-6

Ethyl sorbate 2396-84-1

5-Formyl-2-furansulfonic acid, 31795-44-5 sodium salt

Furfuryl mercaptan 98-02-2

1 ,6-Hexanedithiol 1191-43-1 trans-2-Hexenoic acid 13419-69-7 trans-2-Hexen-1-ol 928-95-0

4-(4-Hydroxyphenyl)-2-butanone 5471-51-2 lsopulegol 89-79-2 lsopulegyl acetate 89-49-6

2-Ketobutyric acid 600-18-0

(-)-Limonene 5989-54-8

4-Methoxyphenylacetone 122-84-9

Methyl cyclohexanecarboxylate 4630-82-4

3-Methylcyclohexanone 591-24-2

3-Methyl-2-cyclohexen-1 -one 1193-18-6

3-Methyl-1 ,2-cyclopentanedione 765-70-8

TABLE 2

Name CAS #

3-Methyl-2-cyclopenten-1 -one 2758-18-1

N-Methyl-D-glucamine 6284-40-8

Methyl 3-(methylthio)propionate 13532-18-8

4-Methyl-5-thiazoleethanol 137-00-8

5-Methyl~2- 13679-70-4 thiophenecarboxaldehyde

DL-3-Methylvaleric acid 105-43-1

(-)-Myrtenal 564-94-3

Nopol 128-50-7 gamma-Octanoic lactone 104-50-7

3-Octanol 589-98-0

E-2-Octenoic acid 1871-67-6

Pamoic acid 130-85-8

4-PhenyI-2-butyI acetate 10415-88-0

1 -Phenyl-1 ,2-propanedione 579-07-7

2-Phenylpropyl butyrate 80866-83-7

2-Phenylpropyl isobutyrate 65813-53-8 cis-2-Hexen-1-oI 928-94-9

Bis(methylthio)methane 1618-26-4

Magnesium carbonate 39409-82-0 hydroxide, Light

N-Acetyl-L-methionine 65-82-7

4-Methyl-5-vinylthiazole 1759-28-0

2-Methyl-1 -phenyl-2-propanol 100-86-7

3-Phenylpropionaldehyde 104-53-0

N-Benzyl-2-phenylethylamine 3647-71-0

1-Phenylethyl propionate 120-45-6

3-Phenylpropyl isobutyrate 103-58-2

AIIyI hexanoate 123-68-2 alpha, 4-Dimethylbenzylalcohol 536-50-5

TABLE 2

Name CAS #

(-)-Menthyl lactate 59259-38-0

2,6-Dimethylthiophenol 118-72-9

2,4,5-Trimethylthiazole 13623-11 -5

Ethyl 3-(methylthio)propionate 13327-56-5

Phenylethyl isovalerate 140-26-1

2-Propylpyrazine 18138-03-9

2-Methyltetrahydrofuran-3-one 3188-00-9

Ethyl 2-(methyldithio)propionate 23747-43-5

3,4-(Dimethyl-1 ,2- 13494-06-9 cyclopentanedione

Difurfurylsulfide 13678-67-6

Difurfuryldisulfide 4437-20-1

3-(Methylthio)propanol 505-10-2

Methyl phenyl disulfide 14173-25-2

2-(Methyldithio)- 67952-60-7 isobutyraldehyde

Methyl 2-thiofuroate , 13679-61-3

2-lsobutylthiazole 18640-74-9

4-Methyl-5-thiazolylethyl acetate 656-53-1

2-AcetylthiazoIe 24295-03-2

2-Ethyl-3,5(6)-dimethylpyrazine 27043-05-6

5-Methyl-6,7-dihydro-5H- 23747-48-0 cyclopenta(b)pyrazine

Cinnamyl acetate 103-54-8

2,5-Dihydroxy-2,5-dimethyl-1 ,4- 55704-78-4 dithiane

5,6,7,8-Tetrahydroquinoxaline 34413-35-9

2-Methyl-3-furanethiol 28588-74-1

Styrallyl acetate 93-92-5

2-Methylhexanoic acid 4536-23-6

TABLE 2

Name CAS #

2-Methylheptanoic acid 1188-02-9

2,2,6-Trimethylcycloheanone 2408-37-9

L-Tyrosine ethyl ester 4089-07-0 hydrochloride

Ethyl 4-methoxybenzoate 94-30-4

4-Ethylbenzaldehyde 4748-78-1

N-Ethyl-p-menthane-3- 39711-79-0 carboxamide

1 -(2-Furyl)-1 ,3-butanedione 25790-35-6

Menthofuran 494-90-6

Methylsulfuric acid sodium salt 512-42-5

Sucrose diacetate 126-13-6 hexaisobutyrate

N,2,3-Trimethyl-2- 51115-67-4 isopropylbutamide

Tripropionin 139-45-7

(+/-)-Citronellic acid 502-47-6

5-Acetyl-2,4-dimethylthiazole 38205-60-6

Neryl acetate 141-12-8

Benzyl propionate 122-63-4

1 R-(-)-Camphorsulfonic acid 35963-20-3

3,4-Hexanedione 4437-51-8 cis-3-Hexenoic acid 4219-24-3 cis-4-Heptenal 6728-31-0

(E,Z)-2,6-nonadienal 557-48-2 trans-2,trans-6-Nonadienal 17587-33-6

4-Methyl-2-pentenal 5362-56-1 cis-6-Nonenal 2277-19-2

Methyl propyl disulfide 2179-60-4

8-p-Menthen-1-ol 138-87-4

TABLE 2

Name CAS # p-Menthan-2-one 499-70-7

Bisabolene 495-62-5

Ethyl cyclohexanecarboxylate 3289-28-9

Phenylpyruvate 156-06-9

Hydroxypyruvate 1113-60-6

4-Methyl-2-oxopentanoate 816-66-0

(+)-Neomenthol 2216-52-6 trans-Citral 141-27-5

Piperitenone 491-09-8

Sabinene hydrate 546-79-2

Perillyl aldehyde 2111-75-3

2-Hydroxyethanesulfonate 107-36-8

Acetyl isovaleryl 13706-86-0

Acetyl valeryl 96-04-8

Butylidene phthalide 551-08-6

Carvacryl ethyl ether 4732-13-2

Ethyl vanillin propylene glycol 68527-76-4 acetal

Hexyl hexanoate 6378-65-0

2-M ethyl-5-(methylth io)-f u ra n 13678-59-6

2-Methyl-4-pentenoic acid 1575-74-2

2-Methyl-4-propyl-1 ,3-oxathiane 67715-80-4

3-Methylthio-1 -hexanol 51755-66-9 cis-6-Nonenol 35854-86-5

Rose oxide 16409-43-1

L-Linalool 126-91-0

5,6-Dimethyl-8- 4674-50-4 isopropenylbicyclo[4,4,0]dec-1 - en-3-one

2-Ethyl-3,5-dimethylpyrazine 13925-07-0

TABLE 2

Name CAS #

2-lsopropylpyrazine 29460-90-0

2-Isobutyl-3-methyl-pyrazine 13925-06-9

2-Methoxy-3-sec-butyl-pyrazine 24168-70-5

2-Methylthio-3(6)-methyl- 67952-65-2 pyrazine

Benzylcarbinyl propionate 122-70-3

Bornyl acetate 76-49-3 furaneol 3658-77-3

Methoxycinnamaldehyde 1963-36-6

Methylphenol, hydrogen sulfate 68127-34-4

Lactitol monohydrate 81025-04-9

2H-Pyrrole, 3,4-dihydro- 5724-81-2

2-Butenal, 2-methyl-, (E)- 497-03-0

2-Pentenal 764-39-6

Ethanethioic acid, S-methyl 1534-08-3 ester

2-Hexenal 505-57-7

2-Methyi-2-pentenal 623-36-9

Cyclopentanethiol 1679-07-8

Butane, 2-ethoxy- 2679-87-0

S-Ethyl thioacetate 625-60-5 ethyl methyl carbonate 623-53-0

3(2H)-Furanone, 2,5-dimethyl- 14400-67-0

AIIyI propionate 2408-20-0 methyl 2-methylbutanoate 868-57-5

2-Butanone, i-(methylthio)- 13678-58-5

Ethanethioic acid, S-propyl ester 2307-10-0

1 ,2-Butanedithiol 16128-68-0

6-Methyl-3,5-heptadiene-2-one 1604-28-0

2-Octen-4-one 4643-27-0

TABLE 2

Name CAS #

2,5-dimethyl-3-furanthiol 55764-23-3

2-Heptenoic acid 189999-28-5

Butanoic acid, 2-propenyl ester 2051-78-7

6-Methyl-5-hepten-2-ol 1569-60-4 trans-2-Octen-4-ol 20125-81-9 cis-3-Octen-1-ol 20125-84-2

1-Butanol, 2-methyl-, acetate 624-41-9

4-methyl-alpha-methylstyrene 1195-32-0 trans-3-Phenyl-2-propen-1 -ol 4407-36-7

Benzeneacetaldehyde, alpha- 93-53-8 methyl-

Benzene, (2-methoxyethyl)- 3558-60-9

Cyclohexene, 1-methyl-4-(1- 7705-14-8 methylethenyl)-, (+-)-

Phenol, 2-(methylthio)- 1073-29-6

2-Hexen-1-yl acetate 2497-18-9

3-Hexen-1-ol, acetate, (Z)- 3681-71-8

5-Hydroxy-4-octanone 496-77-5 butyl 2-methylpropanoate 97-87-0

Benzofuran-2-carboxaldehyde 4265-16-1

DL-Lysine 70-54-2

1-Hexanethiol, 2-ethyl- 7341-17-5

2',4'-Dimethylacetophenone 89-74-7

2-Pentylpyridine 2294-76-0

1-Methoxy-4-propyl benzene 104-45-0

1 -Hydroxy-2-methoxy-4-ethyl 2785-89-9 benzene

Nonalactone 6008-27-1

Cyclohexyl propionate 6222-35-1

AIIyI 2-ethylbutyrate 7493-69-8

TABLE 2

Name CAS #

Butanoic acid, 3-oxo, 2- 7779-75-1 methylpropyl ester n-Butyl pentanoate 591-68-4

3,7-Dimethyl-1 -octanol 106-21-8

3~Buten-2-one, 3-methyl-4- 1901-26-4 phenyl-

2-Propenoic acid, 3-phenyl-, 1754-62-7 methyl ester, (E)-

Benzene, 4-ethenyl-1 ,2- 6380-23-0 dimethoxy-

Benzenepropanol, alpha, alpha- 103-05-9 dimethyl-

Benzene, (butoxymethyl)- 588-67-0

Dimethyl anthranilate 85-91-6

2-Hexanoylfuran 14360-50-0

Cyclohexyl butyrate 1551-44-6

Naphthalene, 2-ethoxy- 93-18-5

Acetoacetic acid isoamyl ester 2308-18-1

Propanoic acid, 2-methyl-, 4- 103-93-5 methylphenyl ester

4-(4-Methoxyphenyl)-2- 104-20-1 butanone lsobutyl benzoate 120-50-3

Benzene, 1 ,2-dimethoxy-4-(1- 93-16-3 propenyl)- beta- 10415-87-9

Phenylethylmethylethylcarbinol

1 ,1-Dimethoxy-2-phenylpropane 90-87-9

Geranyl formate 105-86-2

Bornyl formate 7492-41-3

I

TABLE 2

Name CAS #

6-Octen-1-ol, 3,7-dimethyl-, 105-85-1 formate

Benzeneacetic acid, butyl ester 122-43-0

3,5,9-Undecatrien-2-one, 6,10- 141-10-6 dimethyl-

Anisyl propionate 7549-33-9

Butanoic acid, 3-phenyl-2- 103-61-7 propenyl ester

2-Propenoic acid, 3-phenyl-, 2- 122-67-8 methylpropyl ester

Eugenyl acetate 93-28-7

3-Methylbutyl phenylacetate 102-19-2

Benzoic acid, 2-(methylamino)-, 65505-24-0

2-methylpropyl ester

Phenoxy ethyl isobutyrate 103-60-6

Anisyl butyrate 6963-56-0

2,6-Octadien-1-ol, 3,7-dimethyl-, 105-91-9 propanoate, (Z)- lsobomyl propionate 2756-56-1

1 ,3,5-Trithiane, 2,2,4,4,6,6- 828-26-2 hexamethyl-

Geranyl N-butyrate 106-29-6

Geranyl isobutyrate 2345-26-8

Thiophene, 2,2'-dithiobis- 6911-51-9

2-Propenoic acid, 3-phenyl-, 7779-17-1 cyclohexyl ester

Benzeneacetic acid, 3-phenyl-2- 7492-65-1 propenyl ester

Anisyl phenylacetate 102-17-0

2-Propenoic acid, 3-phenyl-, 3- 122-68-9

TABLE 2

Name CAS # phenyl propyl ester

Geranyl phenylacetate 102-22-7 hexyl 2-methylbutyrate 10032-15-2

4-heptanolide 105-21-5

Neral 106-26-3

(E)-2-octenol 18409-17-1

Ethyl 3-hydroxyhexanoate 2305-25-1 isopropyl hexanoate 2311-46-8 hexyl butanoate 2639-63-6 bis(2-methyl-3-furyl)disulfide 28588-75-2

3-hydroxy-4,5-dimethyl-2(5H)- 28664-35-9 furanone

2-acetyl-2-thiazoiine 29926-41-8

(E,E)-2,4-octadienal 30361-28-5 geranyl acetone 3796-70-1

1-octen-3-one 4312-99-6

3-mercapto-2-pentanone 67633-97-0

(Z)-3-hexenal 6789-80-6

4-hexanolide 695-06-7

5-octanolide 698-76-0 delta-decalactone 705-86-2

4-vinylguaiacol 7786-61-0

Amyl alicylate 2050-08-0

Cyclohexyl formate 4351-54-6

Dimethylbenzylcarbinyl acetate 151-05-3

Geranyl propionate 105-90-8

Terpinyl acetate 80-26-2 isopropyl 3-methylbutanoate 32665-23-9 isopropyl 2-methylbutanoate 6676-71-4

3-Hexenyl 3-methylbutanoate 10032-11 -8

I

TABLE 2

Name CAS # lsoamyl 2-methylbutyrate 27625-35-0

3-Octyl acetate 4864-61-3

Benzyl isobutyrate 103-28-6

Cis-3-hexenyl butyrate 16491-36-4

Cis-3-hexenyl lactate 61931-81-5

Citronellyl butyrate 141-16-2

Citronellyl propionate 141-14-0 lsoamyl hexanoate 2198-61-0

1 ,3,5-Undecatriene 16356-11-9

1 -Benzyloxy-2-methoxy-4- 120-11-6 propenyl benzene

1-Octen-3-yl acetate 198242

2-Acetyl-3-ethyl pyrazine 32974-92-8

2-lsopropyl-4-methyl thiazole 15679-13-7

2-Methyl-2-pentenoic acid 3142-72-1

2-sec-butyl thiazole 18277-27-5

4,5-Dimethyl thiazole 3581-91-7

4-(2,6,6-Trimethyl-2-cyclohexen- 31499-72-6

1-yl)butan-2-one

4-(2,6,6-Trimethyl cyclohexa- 23696-85-7

1 ,3-dienyl)but-2-en-4-one

Acetaldehyde phenethyl propyl 7493-57-4 acetal

Acetaldehyde ethyl cis-3- 28069-74-1 hexenyl acetal

Acetone propylene glycol acetal 1193-11-9

Acetyl isoeugenol 93-29-8

2-Acetyl~5-methyl furan 1193-79-9

AIIyI cyclohexylbutyrate 7493-65-4

Alpha.alpha- 10094-34-5

TABLE 2

Name CAS # dimethylphenethylbutyrate

Alpha.alpha-dimethyl phenethyl 10058-43-2 formate

Alpha, beta-santalol 11031-45-1

Alpha-amyl cinnamaldehyde 91-87-2 dimethyl acetal

Alpha-fenchyl acetate 13851-11-1

Alpha-furfuryl pentanoate 36701-01-6

Alpha-ionol 25312-34-9

6-Methyl-alpha-ionone 79-69-6

Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehyde

Alpha-n-amyl-beta-phenylacryl 7493-78-9 acetate

Alpha-piperitone 6091-50-5

Alpha-n-amyl-beta-phenyl acryl 7493-80-3 isovalerate

6-Amyl-alpha-pyrone 27593-23-3

Anisyl formate 122-91-8

Benzylcarbinyl 2-methyl butyrate 24817-51-4

Benzylcarbinyl 3-phenyl 103-53-7 propenoate

Benzylcarbinyl alpha-toluate 102-20-5

Benzylcarbinyl butyrate 103-52-6

Benzylcarbinyl caproate 6290-37-5

Benzylcarbinyl formate 104-62-1

Benzylcarbinyl isobutyrate 103-48-0

Benzylcarbinyl salicylate 87-22-9

Benzylcarbinyl tiglate 55719-85-2

Benzvl dioroDvl ketone 7492-37-7

TABLE 2

Name CAS #

Benzyl tiglate 37526-88-8

Beta-homocyclocitral 472-66-2

Beta-ionol 22029-76-1

3-Phenylpropyl propanoate 122-74-7

Bois de rose oxide 7392-19-0

Butyl 2-methyl butyrate 15706-73-7

Butyl cinnamate 538-65-8 ortho-sec-Butyl cyclohexanone 14765-30-1 isobutyl cis-2-methyl-2- 7779-81-9 butenoate

5-n-Butyl-delta-valerolactone 3301-94-8

Campholenic aldehyde 4501-58-0

Cedran-8-yl acetate 77-54-3

Cinnamyl isovalerate 140-27-2

Cis-3-hexenyl benzoate 25152-85-6

Cis-3-hexenyl caproate 31501-11-8

Cis-3-hexenyl formate 33467-73-1

Cis-3-hexenyl isobutyrate 41519-23-7

Cis-3-hexenyl phenylacetate 42436-07-7

Cis-3-hexenyl propionate 33467-74-2

Cis-3-hexenyl tiglate 67883-79-8

Cis-3-hexenyl valerate 35852-46-1 cis-4-Hepten-1-ol 6191-71-5

Cis-5-octen-1-ol 64275-73-6

Citral dimethyl acetal 7549-37-3

Citronellyl isobutyrate 97-89-2

Citronellyl isovalerate 68922-10-1

Citronellyl valerate 7540-53-6

Citroxide 7416-35-5

Cocal 21834-92-4

TABLE 2

Name CAS # p-Cresyl alpha-toluate 101-94-0 p-Cresyl isovalerate 55066-56-3

Dehydro-beta-cyclocitral 116-26-7

8,8-Diethoxy-2,6-dimethyl-2- 7779-94-4 octanol

5,7-Dihydro-2-methyl thieno(3,4- 36267-71-7 d)pyrimidine

2,5-Dihydro-4,5-dimethyl-2-(2- 65894-83-9 methyl propyl)thiazole

Dihydrojasmone 1128-08-1

Dihydroxyacetophenone 28631-86-9

1 ,1-Dimethoxy-3,7-dimethyl-7- 141-92-4 octanol

3,7-Dimethyl-1 ,6-octadien-3-yl 126-64-7 benzoate

3,7-Dimethyl-1 ,6-octadien-3-yl 78-36-4 butyrate

3,7-Dimethyl-1 ,6-octadien-3-yl 78-35-3 isobutyrate

3,7-Dimethyl-1 ,6-octadien-3-yl 144-39-8 propanoate cis-3,7-Dimethyl-2,6-octadien-1- 2345-24-6 yl 2-methyl propanoate

2,4-Dimethyl-3-cyclohexene-1 - 68039-49-6 carboxaldehyde

2,6-Dimethyl-5-hepten-1 -al 106-72-9 trans,cis-2,6-Dodecadien-1 -al 21662-13-5

Eglantal 26643-91-4

Ethyl E-2-bexenoate 27829-72-7

Ethyl tiglate 5837-78-5

TABLE 2

Name CAS #

Ethyl trans-4-decenoate 76649-16-6

5-Ethyl-4-hydroxy-2-methyl- 27538-09-6

3[2H]furanone

2-Ethyl-4-methyl thiazole 15679-12-6

2,6,10-Tπmethyl-2,6,10- 762-29-8 pentadθcatrien-14-one

Guaiacyl phenyl acetate 4112-89-4

3-Hepten-2-one 1119-44-4 trans-2-Hexen-1-ol 2305-21-7

Trans-2-hexenyl butyrate 53398-83-7

Hexyl phenylacetate 5421-17-0

Hexyl propionate 2445-76-3

Hydroxycitronellol 107-74-4 lsobutyl 2-butenoate 589-66-2 lsobutyl salicylate 87-19-4 lsodihydro lavandulal 35158-25-9 lsoeugenyl phenyl acetate 120-24-1 lsopropyl alpha-methylcrotonate 1733-25-1 p-Menth-1-en-8-yl propionate 80-27-3

Menthalactone 13341-72-5

3-Methoxy-p-cymene 1076-56-8

Methyl 4-methyl pentanoate 2412-80-8 alpha-Methyl benzyl formate 7775-38-4

2-Methylbutyl 2-methylbutanoate 2445-78-5

Methyl c-2-octenoate 2396-85-2 p-Methyl hydratropaldehyde 99-72-9

3-(5-Methyl-2-furyl)butanal 31704-80-0

Nerol oxide 1786-08-9 trans,cis-2,6-Nonadien-1 -ol 7786-44-9 trans-2-Octen-1-yl acetate 3913-80-2

TABLE 2

Name CAS #

3-Octen-2-one 1669-44-9

2-Phenyl-2-butenal 4411 -89-6

2-Propionylthiazole 43039-98-1

1-Hydroxy-2-butanone 5077-67-8

2-Butanone, 3-hydroxy-, (+-)- 52217-02-4

Thiazole, 2,5-dimethyl- 4175-66-0

Butanethioic acid, S-methyl 2432-51-1 ester

2,4-Hexadienoic acid, methyl 689-89-4 ester, (E ₁ E)-

Benzeneacetaldehyde, 4- 104-09-6 methyl-

Bicyclo[4.1.0]hept-3-ene, 3,7,7- 498-15-7 trimethyl-, (1S)-

Ethyl 3-hexenoate 2396-83-0

1 H-Pyrrole, 1-(2-furanylmethyl)- 1438-94-4

6-Octenal, 3,7-dimethyl-, (R)- 2385-77-5

Ethanethioic acid, S-(2- 13678-68-7 furanylmethyl) ester

6-Octen-1-ol, 3,7-dimethyl-, (R)- 1117-61-9

6-Octen-1-ol, 3,7-dimethyl-, (S)- 7540-51-4

DL-Tetrohydrofurfuryl propionate 637-65-0

Benzenepentanol 10521-91-2

Cyclohexaneethanol, acetate 21722-83-8

Benzyl isobutyl ketone 5349-62-2

Butanoic acid, 3-oxo-, 5396-89-4 phenylmethyl ester

1 ,2-Ethanediamine, N,N'- 140-28-3 bis(phenylmethyl)-

2-Ethyl-3-hydroxy-4-pyrone 1110651

I

TABLE 2

Name CAS #

Dicyclohexyl disulfide 2550-40-5

Tetrahydrofurfuryl butyrate 2217-33-6

Thujone 546-80-5

Benzyl alcohol, alpha-methyl-, 3460-44-4 butyrate

Citronellyl tiglate 24717-85-9

Lacitol 585-86-4

Nonivamide 244-46-4

2-Acetoxy-3-butanone 4906-24-5

3-Acetyl-2,5-dimethylthiophene 230378

3-Acetyl-2-5dimethylfuran 10599-70-9

4-Acetyl-6-t-butyl-1 ,1- 13171-00-1 dimethylindan

AIIyI 2-furoate 4208-49-5

AIIyI sorbate 7493-75-6

AIIyI thiopropionate 41820-22-8

AIIyI tiglate 7493-71-2

Amylcyclohexyl acetate 67874-72-0

Benzaldehyde glyceryl acetal 1319-88-6

Benzaldehyde propylene glycol 2568-25-4 acetal

Bornyl isovalerate 76-50-6

1 ,3-Butanedithiol 24330-52-7

2,3-Butanedithiol 4532-64-3

Butyl cinnamic aldehyde 7492-44-6

Cinnamyl benzoate 5320-75-2

Citral ethylene glycol acetal 66408-78-4

Citronellyloxyacetaldehyde 7492-67-3

Citrionellyl phenylacetate. 139-70-8

Cyclohexyl isovalerate 7774-44.9

TABLE 2

Name CAS #

Decalactone 5579-78-2

2,5-Dimethyl-4-methoxy-3(2H)- 4077-47-8 furanone

6,10-Dimethyl-9-undecen-2-one 4433-36-7

2-Et.hoxythiazole 15679-19-3

Ethyl 2-mercaptopropionate 19788-49-9

Ethyl 2-methyl-4-pentenoate 53399-81-8

Ethyl 3-(2-furyl)propanoate 94278-27-0

Ethyl cyclohexanepropionate 10094-36-7

Ethyl (p-tolyloxy)acetate 67028-40-4

3-Ethyl-2-hydroxy-2- 21835-01-8 cyclopenten-1-one

Ethylene brassylate 105-95-3

2-Ethylfenchol 18368-91-7

Furfuryl 3-methylbutanoate 13678-60-9

Furfuryl butyrate 623-21-2

Furfuryl isopropyl sulfide 1883-78-9

Furfuryl methyl sulfide 1438-91-1

Furfuryl propionate 623-19-8

Furfuryl thiopropionate 59020-85-8

Geranyl acetoacetate 10032-00-5

Geranyl benzoate 94-48-4

Geranyl isovalerate 109-20-6 delta-Hexalactone 823-22-3 trans-3-Hexenal 69112-21-6 cis-3-Hexenyl anthranilate 65405-76-7 trans-2-Hexenyl propionate 53398-80-4

5-(cis-3-Hexenyl) dihydro-5- 70851-61-5 methyl-2(3H)furanone

39251-86-0

TABLE 2 Name CAS #

19089-92-0

629-33-4

7779-67-1

7779-72-8

105-01-1

37677-14-8

4395-92-0

78-37-5

115-99-1

1118-27-0

7143-69-3

65416-14-0

2177-77-7

21188-58-9

13481-87-3

57500-00-2

3549-23-3

3008-43-3

104-27-8

2445-77-4

45019-28-1

54947.74.9

13679-85-1

16630-52-7

20582-85-8

34047-39-7

23550-40-5

999-40-6

2142-94-1

3915-83-1

TABLE 2 Name CAS #

4430-31-3

7149-32-8

705-73-7

68345-22-2

29895-73-6

2110-18-1

4606-15-9

35250-53-4

39255-32-8

4493-42-9

127-51-5

628-46-6

5870-68-8

60523-21-9

14309-57-0

5166-53-0

68555-63-5

874-66-8

10031-90-0

57568-60-2

1599-49-1

53833-30-0

7779-73-9

652-37-9

7367-82-0

7200-25-1

20474-93-5

612-15-7

7704-71-4

1073-26-3

TABLE 2

Name CAS #

5616-51-3

13360-64-0

65505-17-1

3632-91-5

6485-39-8

149-32-6

28697-53-2

59-23-4

3458-28-4

50-70-4

22839-47-0

100-88-9

150-69-6

29732-59-0

87-72-9

643-13-0

6363-53-7

24259-59-4

26177-85-5

6155-57-3 6485-34-3

10332-51-1

26538-44-3 7660-25-5 488-69-7 4300-28-1

TABLE 2

Name CAS #

147-81-9

82385-42-0

585-88-6

15978-08-2

108392-12-

31178-70-8

573-35-3

Table 3 sets forth the group comprising molecules believed at present to be suitable guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 3

Name CAS #

Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate 7558-79-4

Sodium Phosphate Monobasic 7558-80-7

Sodium thiosulfate 7772-98-71

Orthoboric acid 10043-35-3

Diethanolamine 111-42-2

Benzaldehyde 100-52-7

Sorbic acid 110-44-1

L-(+) Tartaric Acid 87-69-4

D-mannnitol 69-65-8

Butyl paraben 94-26-8

Thymol 89-83-8

Methyl salicylate 119-36-8

Citric acid 77-92-9

Creatinine 60-27-5

TABLE 3

Name CAS #

Vitamin C 50-81-7

Benzoic Acid 65-85-0

Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4 p-Cresol 106-44-5

Aspirin 50-78-2

Phenol 108-95-2

Sucrose 57-50-1

Potassium citrate, monohydrate 1534146

Sodium acetate 127-09-3

Lactic acid 50-21-5

Propionic acid, sodium salt 65-85

Benzyl alcohol 100-51-6

Phenethyl alcohol 60-12-8

Cholesterol 57-88-5

D-Glucose 50-99-7

Sorbitol 50-70-4

Aspartame 22839-47-0

Saacharin 81-07-2

2,6-Di-tert-Butyl-p-Cresol 128-37-0

4-Chloro-3-methyIphenol 59-50-7 glycerin 56-81-5

Propyl paraben 94-13-3 fu marie acid 110-17-8 dabco 280-57-9 p-Phenylenediamine 106-50-3

Anethole 4180-23-8 propyl gallate 121-79-9

L-monosodium glutamate 142-47-2

Butylated hydroxyanisole 25013-16-5

TABLE 3 Name CAS #

Cyclohexanol, 5-methyl1-2-(1- 89-78-1 methylethyl)-, (1 alpha, 2beta,

5alpha)-

Alpha-Thioglycerol 96-27-5

Sodium dehydroacetate 4418-26-2

Ethyl 4-hydroxybenzoate 120-47-8

Ethyl Vanillin 121-32-4

Triacetin 102-76-1

Potassium sorbate 590-00-1

Triethyl citrate 77-93-0

(S)-(+)-Arginine 74-79-3

Glycine 56-40-6

(S)-(-)_Histidine 71-00-1

(S)-(+)-Lysine 56-87-1

Quinone 106-51-4

Naphthalene, 2-ethoxy- 93-18-5

Methanesulfonic Acid 75-75-2

DL-Tartaric Acid 133-37-9

Cyclamic acid 100-88-9

(S)-(-)-Phenylalanine 63-91-2

(S)-(-)-Tyrosine 60-18-4

Carvone 99-49-0

Ethyl butynate 105-54-4

6-Methyl-5-hepten-2-one 110-93-0

Ethyl acetoacetate 141-97-9

Methyl benzoate 93-58-3

Phenylacetic Acid 103-82-2

Adipic acid 124-04-9

Ethyl benzoate 93-89-0

Benzyl benzoate 120-51-4

TABLE 3

Name CAS #

Pyruvic acid 127-17-3

Succinic acid 110-15-6

Indole 120-72-9

Methyl anthranilate 134-20-3

Diethyl malonate 105-53-3

Niacin 59-67-6

Meso-inositol 87-89-8

4-Aminobenzoic acid 150-13-0

Anisole 100-66-3

Urea 57-13-6

Pyrrolidine 123-75-1

Cyclopentanone 120-92-3

Acetic anhydride 108-24-7

Benzophenone 119-61-9

D-(-)-Fructose 57-48-7

D-(+)-Xylose 58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethyl isovalerate 108-64-5

1 , 1 '-Azobisformamide 123-77-3

6-Methylcoumarin 92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2

Cymene 99-87-6

Dimethyl Succinate 106-65-0 p-Anisaldehyde 123-11-5

Phenyl ether 101-84-8

Tetrahydro-2-furanmethanol 97-99-4

Valeric Acid 109-52-4

3,4-xylenol 95-65-8

TABLE 3

Name CAS #

1 ,1-dιethoxyethane 105-57-7 ethyl butyraldehyde 97-96-1

Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 methyl isovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde 123-15-9

4-(2,6,6-Trimethyl-2-cyclobexen- 127-41-3

1-yl)-3-buten-2-one

4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1 -yl)-3-buten-2-one

Maleic acid 110-16-7

3-Methylbutanoic acid 503-74-2

L-Glutamic Acid 56-86-0

D-limonene 5989-27-5

1 -Phenyl-1 -propanol 93-54-9

2-Hydroxyacetophenone 118-93-4

2,4-Dihydroybenzoic Acid 89-86-1

2-Phenyl-1 -propanol 1123-85-9

3-Phenylpropionic Acid 501-52-0

4-Ethoxyphenol 622-62-8

Alpha-Terpineol 98-55-5

Benzaldehyde Dimethylacetal 1125-88-8

Benzyl Ether 103-50-4

Benzyl Formate 104-57-4

Benzyl Salicylate 118-58-1

Cinnamyl Alcohol 104-54-1

D-(+)-Glucono-1 ,5-lactone 4253-68-3

D-lsoascorbic Acid 89-65-6

2,3-NaphtaIenediol 92-44-4

TABLE 3

Name CAS #

Diethyl Succinate 123-25-1

Ethyl 2-Aminobenzoate 87-25-2

Ethyl Cinnamate 103-36-6

Ethyl Phenylacetate 101-97-3

Ethyl Salicylate 118-61-6 gamma-Valerolactone 108-29-2

Hydroquinone Dimethyl Ether 150-78-7 lsocaproic Acid 646-07-01 lsoeugenol 97-54-1 lsopropyl Benzoate 939-48-0

L-(+)-lsoleucine 73-32-5

L-Malic acid 97-67-6

L-2-Aminopropionic Acid 56-41-7

L-Camitine 541-15-1

L-Glutamine 56-85-9

L-Hydroxyproline 51-35-4

L-Proline 147-85-3

L-Serine 56-45-1

L-Threonine 72-19-5

L-Valine 72-18-4

Phenoxyacetic Acid 122-59-8

Veratrole 91-16-7

2-Ethyl butyric acid 88-09-5

2-Methylpyrazine 109-08-0 o-methoxybenzaldehyde 135-02-4

L-Leucine 61-90-5

L-Asparagine 70-47-3 propiophenone 93-55-0

5-isopropyl-2-methyl-phenol 499-75-2

Xylitol 87-99-0

TABLE 3

Name CAS # ethyl 4-oxopentanoate 539-88-8 methyl cinnamate 103-26-4 cumic alcohol 536-60-7 methyl 2-naphthyl ketone 93-08-3

1 -methyl-4-(1 -methylethyl)- 99-85-4

1 ,4-Cyclobexadiene en-ethylene diamine

Caffeine 58-08-2

5-methylfurfural 620-02-0 furfuryl acetate 623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-1

4'-Methoxyacetophenone 100-06-01

D-Fenchone 4695-62-9

1 -Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5

Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenone 122-00-9

Methyl phenylacetate 101-41-7

4-Ethoxybenzaldehyde 10031-82-0 p-tolyl acetate 140-39-6

2,6-Dimethoxyphenol 91-10-1

Methyl 2-methoxybenzoate 606-45-1 alpha-methlcinnamaldehyde 101-39-3

2-methoxycinnamaldehyde 60125-24-8

Potassium bicarbonate 298-14-6 piperonyl acetate 326-61-4

2,3-hexanedione 3848-24-6 furfural acetone 623-15-4

TABLE 3 Name CAS # trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9

Methyl nicotinate 93-60-7

Ethyl benzoylacetate 94-02-0

Methyl 4-methoxybenzoate 121-98-2

Luvulinic acid 123-76-2 m-Dimethoxybenzene 151-10-0

2-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-4

2,3-dimethyl-pyrazine 5910-89-4 trimethyl-pyrazine 14667-55-1

2-ethyl-3-methyl-pyrazine 15707-23-0

5-Methyl-3H-furan-2-one 591-12-8

2-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-0

2-Methoxy-4-propylphenol 2785-87-7

Naphthalene, 2-(2- 2173-57-1 methylpropoxy)-

2-Acetyl-1 -methylpyrrole 932-16-1

3,3-Dimethylacrylic acid 541-47-9

Ethyl sorbate 2396-84-1

4-(4-Hydroxyphenyl)-2-butanone 5471-51-2

4-Methoxyphenylacetone 122-84-9

(-)-Myrtenal 564-94-3

3-Phenylpropionaldehyde 104-53-0

1-Phenylethyl propionate 120-45-6

2-Methyltetrahydrofuran-3-one 3188-00-9

Cinnamyl acetate 103-54-8

Styrallyl acetate 93-92-5

Ethyl 4-methoxybenzoate 94-30-4

TABLE 3 Name CAS #

Benzyl propionate 122-63-4

Phenyl pyruvate 156-06-9 furaneol 3658-77-3 methyl 2-methylbutanoate 868-57-5

Benzeneacetaldehyde, alpha- 93-53-8 methyl-Dimethyl anthranilate 85-91-6

1 ,1-Dimethoxy-2-phenylpropane 90-87-9

4-hexanolide 695-06-7

Dimethylbenzylcarbinyl acetate 151-05-3

Benzyl isobutyrate 103-28-6

Acetyl isoeugenol 93-29-8

2-Acetyl-5-methyl furan 1193-79-9

Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehyde 104-62-1

Benzylcarbinyl formate p-Cresyl alpha-toluate 101-94-0

Potassium bisulfate 7646-93-7

Potassium carbonate 584-08-7

Potassium chloride 7447-40-7

Potassium hydroxide 1310-58-3

Ethyl tiglate 5837-78-5

Nerol oxide 1786-08-9

DL-Tetrohydrofurfuryl propionate 637-65-0

Benzaldehyde propylene glycol 2568-25-4 acetal

2-Methyl-3-(2-furyl) acrolein 874-66-8 vanillin 121-35-5

Cholic acid 81-25-4

R-Carvone 6485-40-1

Potassium nitrate 7757-79-1

TABLE 3

Name CAS #

Potassium permanganate 7722-64-7

Potassium persulfate 7727-21-1 Potassium phosphate, dibasic 2139900 potassium Phosphate 7778-77-0 Monobasic ₍

Potassium sulfate 7778-80-5

Sodium bicarbonate 144-55-8

Sodium bisulfite 7631-90-5

Sodium carbonate 497-19-8

Sodium chloride 7647-14-5

Sodium dithionite 7775-14-6

Sodium hydroxide 1310-73-2

Sodium nitrite 7632-00-0

Sodium Pyrophosphate 7722-88-5

Sodium sulfate 7757-82-6

Sodium sulfite 7757-83-7

Sodium thiocyanate 540-72-7

Calcium Carbonate 471-34-1

Calcium chloride 10043-52-4

Calcium gluconate 299-28-5

Calcium hydroxide 1305-62-0

Calcium phosphate, dibasic 7757-93-9

Calcium sulfate 7778-18-9

N-methyl-D-glucamine 6284-40-8

Calcium oxide 1305-78-8 Calcium Phosphate Monobasic 7758-23-8

Magnesium chloride 7791-18-6 hexahydrate

Magnesium sulfate 7487-88-9

Magnesium Sulfate 10034-99-8

TABLE 3

Name CAS #

Heptahydrate

Aluminum chloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2

Aluminum potassium sulfate, 7784-24-9 dodecabydrate

Aluminum sulfate 7784-31-8 octadecahydrate

(S)-(-)-Cysteine 52-90-4 p-Toleunesulfonic Acid 104-15-4

Potassium bitartrate 868-14-4

DL-aspartic acid 617-45-8 p-Dimethylaminobenzaldehyde 100-10-7

Sodium salicylate 54-21-7

Benzoin 119-53-9

Sodium dodecyl sulfate 151-21-3

L-Menthol 2216-51-5

Ti ran 149-45-1

Riboflavin 83-88-5

Sodium Acelate Trihydrate 6131-90-4

Disodium Succinate 6106-21-4

Hexahydrate

Disodium 6381-92-6 ethylenediaminetetraacetate dihydrate sodium citrate, dihydrate 1545801

Sodium potassium tartrate, 6381-59-5 tetrahydrate

L-(+)-Arginine 1119-34-2 monohydrochloride

Ethylenediamine 333-18-6

TABLE 3

Name CAS # dihydrochloride

Sodium formate 141-53-7

Sodium acetate 127-09-3

Potassium acetate 127-08-2

Ammonium citrate 3012-65-5

Ammonium bicarbonate 1066-33-7

Ammonium chloride 12125-02-9

Ammonium nitrate 6484-52-2

Ammonium persulfate 7727-54-0

Ammonium sulfate 7783-20-2

Zinc chloride 7646-85-7

Sulfuric acid, zinc salt 7446-20-0

(1 :1 ), heptahydrate

Sodium Tripolyphosphate 7758-29-4 ammonium henzoate 1863-63-4 ammonium bisulfite . 10192-30-0

1 ,5-Naphthalenedisulfonic Acid 1655-29-4

Disodium Salt

4-Hydroxybenzoic Acid 99-96-7

Diphenylacetic Acid 117-34-0

Glutaric Acid 110-94-1

L-(-)-Fucose 2438-80-4

L-Cysteine Hydrochloride 52-89-1

L-Histidine Hycrochloride 1880304

Monohydrate o-Toluic Acid 118-90-1

Pivalic Acid 75-98-9

Pyruvic Acid Sodium Salt 113-24-6

Potassium bromide 2139626

Sodium Dithionate Dihydrate 7631-94-9

TABLE 3

Name CAS #

Sodium Malonate 141-95-7

Trisodium Citrate 68-04-2

Potassium Sodium Tartrate 304-59-6

Potassium Citrate 866-84-2

D-Maltose Monohydrate 6363-53-7

Cyclohexaamylose 10016-20-3

Dodecyl sulfate, lithium salt 2044-56-6

Manganese chloride 2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9

Triphosphoric acid, 13845-36-8 pentapotassium salt

Glycine ethyl ester 623-33-6 hydrochloride

L-Histidine methyl ester 7389-87-9 dihydrochloride

L-Leucine methyl ester 7517-19-3 hydrochloride

D-Lysine hydrochloride 7274-88-6

2-Naphthalenesulfonic acid 532-02-5 sodium salt calcium nitrate tetrahydrate 13477-34-4

Vitamin B1 59-43-8

Zinc Acetate Dihydrate 5970-45-6

Potassium fluoride 7789-23-3

Potassium iodate 2139718

Potassium iodide 7681-11 -0

Potassium thiocyanate 333-20-0

Sodium bromide 7647-15-6

Sodium flouride 7681-49-4

TABLE 3

Name CAS #

Sodium iodide 7681-82-5

Sodium nitrate 7631-99-4

Calcium acetate 5743-26-0

Trichloracetic acid 76-03-9

Ammonium acetate 631-61-8

Ammonium flouride 12125-01-8

DL-malic acid 617-48-1 t-Butyl Alcohol 75-65-0 beta-AIanine 107-95-9

(S)-(-)-Tryptophan 73-22-3

Malonic acid 141-82-2

Phenethylamine 64-04-0

Salicylylaldehyde 90-02-8

Sodium benzoate 532-32-1

Mandelic acid 90-64-2

Calcium pantothenate 137-08-6

Chloracetic Acid 79-11-8

Ethanol Amine 141-43-5

Salicylic acid 69-72-7

Saccharin sodium 128-44-9

Thiamine hydrochloride 67-03-8

2,2'-Oxybisethanol 111-46-6

Resorcinol 108-46-3

2-Amino-2-(hydroxymethyl)-1 ,3- 77-86-1 propanediol

2,5-Dimethylphenol 95-87-4

Ammonium Phosphate 7722-76-1

Monobasic

1 ,3-Butanediol 107-88-0

Glycolic Acid 79-14-1

TABLE 3

Name CAS #

Sodium gluconate 527-07-1

Terephthalic Acid 100-21-0

L-Ascorbic Acid Sodium Salt 134-03-2

3-Acetyl-6-methyl-2,4- 520-45-6 pyrandione

Calcium Acetate 62-54-4

Nicotinamide 98-92-0

1-Hydroxy-2-napthoic Acid 86-48-6

2-lsopropylphenol 88-69-7

4-Aminosalicyclic Acid 65-49-6

Calcium Glycerophosphate 27214-00-2

Erythorbic Acid Sodium Salt 7378-23-6

Gluconic Acid Potassium Salt 299-27-4

Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5

Acetic anhydride 108-24-7

Benzophenone 119-61-9

D-(-)-Fructose 57-48-7

D-(+)-Xylose 58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethyl isovalerate 108-64-5

1 ,1 '-Azobisformamide 123-77-3

6-Methylcoumarin 92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2

Cymene 99-87-6

Dimethyl Succinate 106-65-0 p-Anisaldehyde 123-11-5

Phenyl ether 101-84-8

TABLE 3 Name CAS #

Tetxahydro-2-furanmethanol 97-99-4

Valeric Acid 109-52-4

3,4-xylenol 95-65-8

1 ,1-diethoxyethane 105-57-7 ethyl butyraldehyde 97-96-1

Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 methyl isovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde 123-15-9

4-(2,6,6-Trimethyl-2- 127-41-3 cyclohexen-1 -yl)-3-buten-2-one

4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1 -yl)-3-buten-2-one

Maleic acid 110-16-7

3-M ethyl butanoic acid 503-74-2

L-Glutamic Acid 56-86-0

D-limonene 5989-27-5

1 -Phenyl-1 -propanol 93-54-9

2'-Hydroxyacetophenone 118-93-4

2,4-Dihydroxybenzoic Acid 89-86-1

2-Phenyl-1 -propanol 1123-85-9

3-Phenylpropionic Acid 501-52-0

4-Ethoxyphenol 622-62-8

Alpha-Terpineol 98-55-5

Bcnzaldehyde Dimethylacetal 1125-88-8

Benzyl Ether 103-50-4

Benzyl Formate 104-57-4

Benzyl Salicylate 118-58-1

Cinnamyl Alcohol 104-54-1

TABLE 3

Name CAS #

D-(+)-Glucono-1 ,5-lactone 4253-68-3

D-lsoascorbic Acid 89-65-6

2,3-Naphthalenediol 92-44-4

Diethyl Succinate 123-25-1

Ethyl 2-Aminobenzoate 87-25-2

Ethyl Cinnamate 103-36-6

Ethyl Phenylacetate 101-97-3

Ethyl Salicylate 118-61-6 gamma-Valenolactone 108-29-2

Hydroquinone Dimethyl Ether 150-78-7 lsocaproic Acid 646-07-1 lsoeugenol 97-54-1 lsopropyl Benzoate 939-48-0

L-(+)-lsoleucine 73-32-5

L-MaNc acid 97-67-6

L-2-Aminopropionic Acid 56-41-7

L-Carnitine 541-15-1

L-Glutamine 56-85-9

L-Hydroxyproline 51-35-4

L-Proline 147-85-3

L-Serine 56-45-1

L-Threonine 72-19-5

L-Valine 72-18-4

Phenozyacetic Acid 122-59-8

Veratrole 91-16-7

2-Ethylbutyric acid 88-09-5

2-Methylpyrazine 109-08-0 o-methoxybenzaldehyde 135-02-4

L-Leucine 61-90-5

L-Asparagine 70-47-3

TABLE 3

Name CAS # propiophenone 93-55-0

5-isopropyl-2-methyl-phenol 499-75-2

Xylitol 87-99-0 ethyl 4-oxopentanoate 539-88-8 methyl cinnamate 103-26-4 cumic alcohol 536-60-7 methyl 2-naphthyl ketone 93-08-3

1 -methyl-4-(1 -methylethyl)- 99-85-4

1 ,4-Cyclohexadiene en — ethylene diamine

Caffeine 58-08-2

5-methylfurfural 620-02-0 furfuryl acetate 623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-1

4'-Methoxyacetophenone 100-06-1

D-Fenchone 4695-62-9

1 -Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5

Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenone 122-00-9

Methyl phenylacetate 101-41-7

4-Ethoxybenzaldehydc 10031-82-0 p-tolyl acetate 140-39-6

2,6-Dimethoxyphenol 91-10-1

Methyl 2-methoxybenzoate 606-45-1 alpha-methylcinnamaldehyde 101-39-3

2-methoxycinnamaldehyde 60125-24-8

Potassium bicarbonate 298-14-6

TABLE 3

Name CAS # piperonyl acetate 326-61-4

2,3-hexanedione 3848-24-6 furfural acetone 623-15-4 trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9

Methyl nicotinate 93-60-7

Ethyl benzoylacetate 94-02-0

Methyl 4-methoxybenzoate 121-98-2

Levulinic acid 123-76-2 m-Dimethoxybenzene 151-10-0

2-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-4

2,3-dimethyl-pyzazine 5910-89-4 trimethyl-pyrazine 14667-55-1

2-ethyl-3-methyl-pyrazine 15707-23-0

5-Methyl-3H-furan-2-one 591-12-8

2-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-0

2-Methoxy-4-propylphenol 2785-87-7

Naphthalene,2-(2- 2173-57-1 methylpropoxy)-

2-Acetyl-1 -methylpyrrole 932-16-1

3,3-Dimethylacrylic acid 541-47-9

Ethyl sorbate 2396-84-1

4-(4-Hydroxyphenyl)-2-butanone 5471-51-2

4-Methoxyphenylacetone 122-84-9

(-)-Myrtenal 564-94-3

3-Phenylpropionaldehyde 104-53-0

1-Phenylethyl propionate 120-45-6

2-Methyltetrahydrofuran-3-one 3188-00-9

TABLE 3 Name CAS #

Cinnamyl acetate 103-54-8

Styrallyl acetate 93-92-5

Ethyl 4-methoxybenzoate 94-30-4

Benzyl propionate 122-63-4

Phenylpyruvate 156-06-9 furaneol 3658-77-3 methyl 2-methylbutanoate 868-57-5

Benzeneacetaldehyde, alpha- 93-53-8 methyl-

Dimethyl anthranilate 85-91-6

1 ,1-Dimethoxy-2-phenylpropane 90-87-9

4-hexanolide 695-06-7

Dimethylbenzylcarbinyl acetate 151-05-3

Potassium Benzoate 582-25-2

Taurine 107-35-7

Thiamine Nitrate 532-43-4

3,3,5-Trimethyl-1 -cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0

Sulfosalicyclic acid 97-05-2

Gallic acid 149-91-7

L-bomeol 464-45-9 lsoborneol 124-76-5

2,5-Dihydroxybenzoic acid, 490-79-9

Gentisic acid

5-hydroxy-6-methyl-3,4- 65-23-6 pyridimedimethanol

Naphthalene-2-sulfonic acid 120-18-3

Ethanesulfonic acid, 2-hydroxy-, 1562-00-1 monosodium salt

Panoic acid 130-85-8

TABLE 3

Name CAS #

2,4-Dimethylphenol 105-67-9

3,5-Dihydroxyacetophenone 51863-60-6

Eugenol 97-53-0 a-Butyric Acid 107-92-6

Hydroquinone 123-31-9

Propionic Acid 79-09-4 meta-Phenylanediamine 108-45-2

Oxalic Acid 144-62-7 n-Hexanoic Acid 142-62-1

2-Furancarboxylic Acid 88-14-2

4'-Nitroacetanilide 104-04-1

D-(-)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1

Galactaric acid 526-99-8

D-glucoronate 1700908

Lactobionic acid 96-82-2 p-Formylacetanilide 122-85-0

2-Mercaptobenzoic acid 147-93-3

Propanioc acid, 2-hydroxy-, 28305-25-1 calcium salt (2:1), (S)-

D(+)-10-Camphorsulfonic acid 3144-16-9

3-Cyclopentylpropionic acid 140-77-2

1 R-(-)-Camphorsulfonic acid 35963-20-3

DL-Lysine 70-54-2

Cinnamic acid 621-82-9

Triethanolamine 102-71-6

Acetic Acid 64-19-7

Dichloroacetic Acid 79-43-6

Diethylamine 109-89-7

Diethylamineothanol 100-37-8

TABLE 3

Name CAS #

N-(2-Hydroxyethyl)Morpholine 622-40-2

Octanoic Acid 124-07-2 isobutyric acid 79-31-2

Anisic Acid 100-09-4

Betaine 107-43-7

Enanthoic Acid 111-14-8

Hippuric Acid 495-69-2

Tiglic Acid 80-59-1

Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9

D-(+)-Camphoric acid 124-83-4

N-(2-Hydroxyethyl)pyrroIidine 2955-88-6

Name CAS #

Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate 7558-79-4

Sodium Phosphate Monobasic 7558-80-7

Sodium thiosulfate 7772-98-71

Orthoboric acid 10043-35-3

Diethanolamine 111-42-2

Benzaldehyde 100-52-7

Sorbic acid 110-44-1

L-(+)-Tartaric Acid 87-69-4

D-mannitol 69-65-8

Butyl paraben 94-26-8

Thymol 89-83-8

Methyl salicylate 119-36-8

Citric acid 77-92-9

Creatinine 60-27-5

Vitamin C 50-81-7

Benzoic Acid 65-85-0

TABLE 3

Name CAS #

Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4 p-Cresol 106-44-5

Aspirin 50-78-2

Phenol 108-95-2

Sucrose 57-50-1

Potassium citrate, monohydrate 1534146

Name CAS #

Sodium acetate 127-09-3

Lactic acid 50-21-5

Propionic acid, sodium salt 65-85

Benzyl alcohol 100-51-6

Phenethyl alcohol 60-12-8

Cholesterol 57-88-5

D-Glucosc 50-99-7

Sorbitol 50-70-4

Aspartame 22839-47-0

Saccharin 81-07-2

2,6-Di-tert-Butyl-p-Crcsol 128-37-0

4-Chloro-3-mcthylphenol 59-50-7 glycerin 56-81-5

Propyl paraben 94-13-3 f u marie acid 110-17-8 dabco 280-57-9 p-Phenylenediamine 106-50-3

Ancthole 4180-23-8 propyl gallate 121-79-9

L-monosodium glutamate 142-47-2

Butylated hydroxyanisole 25013-16-5

Cyclohexanol, 5-mcthyI-2-(1 - 89-78-1

TABLE 3

Name CAS # methylθthyl)-,

(1 alpha,2beta,5alpha)- alpha-Thioglycerol 96-27-5

Sodium dehydroacetate 4418-26-2

Ethyl 4-hydroxybenzoate 120-47-8

Ethyl Vanillin 121-32-4

Triacetin 102-76-1

Potassium sorbate 590-00-1

Triethyl citrate 77-93-0

(S)-(+)-Arginine 74-79-3

Glycine 56-40-6

(S)-(-)-Histidine 71-00-1

(S)-(+)-Lysine 56-87-1

Quinone 106-51-4

Naphthalene, 2-ethoxy- 93-18-5

Methanesulfonic Acid 75-75-2

DL-Tartaric Acid 133-37-9

Cyclamic acid 100-88-9

(S)-(-)-Phenylalanine 63-91-2

(S)-(-)-Tyrosine 60-18-4

Carvone 99-49-0

Ethyl butyrate 105-54-4

6-Methyl-5-hepten-2-one 110-93-0

Ethyl acetoacetate 141-97-9

Methyl benzoate 93-58-3

Phenylacetic Acid 103-82-2

Adipic acid 124-04-9

Ethyl benzoate 93-89-0

Benzyl benzoate 120-51-4

Pyruvic acid 127-17-3

TABLE 3

Name CAS #

Succinic acid 110-15-6

Indole 120-72-9

Methyl anthranilate 134-20-3

Diethyl malonate 105-53-3

Niacin 59-67-6

Meso-inositol 87-89-8

4-Aminobenzoic acid 150-13-0

Anisole 100-66-3

Urea 57-13-6

Pyriolidinc 123-75-1

Cyclopentanone 120-92-3

Benzyl isobutyrate 103-28-6

Acetyl isoeugenol 93-29-8

2-AcetyI-5-methyl furan 1193-79-9

Alpha-methyl-p 103-95-7 isopropylphenylpropanaldehydc

Bcnzylcarbinyl formate 104-62-1 p-Cresyl alpha-toluate 101-94-0

Potassium bisulfate 7646-93-7

Potassium carbonate 584-08-7

Potassium chloride 7447-40-7

Potassium hydroxide 1310-58-3

Ethyl tiglate 5837-78-5

Nerol oxide 1786-08-9

DL-Tetrohyd rof u rfu ryl 637-65-0 propionate

Bcnzaldehyde propylene glycol 2568-25-4 acetal

2-Methyl-3-(2-furyl) acrolein 874-66-8 vanillin 121-33-5

TABLE 3

Name CAS #

Cholic acid 81-25-4

R-Carvone 6485-40-1

Potassium nitrate 7757-79-1

Potassium permanganate 7722-64-7

Potassium persulfate 7727-21-1 Potassium phosphate, dibasic 2139900

Potassium Phosphate 7778-77-0 Monobasic

Potassium sulfate 7778-80-5

Sodium bicarbonate 144-55-8

Sodium bisulfite 7631-90-5

Sodium carbonate 497-19-8

Sodium chloride 7647-14-5

Sodium dithionite 7775-14-6

Sodium hydroxide 1310-73-2

Sodium nitrite 7632-00-0

Sodium Pyrophosphate 7722-88-5

Sodium sulfate 7757-82-6

Sodium sulfite 7757-83-7

Sodium thiocyanate 540-72-7

Calcium Carbonate 471-34-1

Calcium chloride 10043-52-4

Calcium gluconate 299-28-5

Calcium hydroxide 1305-62-0

Calcium phosphate, dibasic 7757-93-9

Calcium sulfate 7778-18-9

N-Methyl-D-glucamine 6284-40-8

Calcium oxide 1305-78-8 Calcium Phosphate Monobasic 7758-23-8

Magnesium chloride 7791-18-6

TABLE 3

Name CAS # hexahydratc

Magnesium sulfate 7487-88-9

Magnesium Sulfate 10034-99-8

Heptahydrate

Aluminum chloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2

Aluminum potassium sulfate, 7784-24-9 dodecahydrate

Aluminum sulfate, 7784-31-8 octadecahydrate

(S)-(-)-Cysteine 52-90-4 p-Toluenesulfonic Acid 104-15-4

Potassium bitartrate 868-14-4

DL-aspartic acid 617-45-8 p-Dimethylaminobenzaldehyde 100-10-7

Sodium salicylate 54-21-7

Benzoin 119-53-9

Sodium dodecyl sulfate 151-21-3

L-Mcnthol 2216-51-5

Tiron 149-45-1

Riboflavin 83-88-5

Sodium Acetate Trihydrate 6131-90-4

Disodium Succinate 6106-21-4

Hexahydrate

Disodium 6381-92-6 ethylenediaminetetraacetate dihydrate sodium citrate, dihydrate 1545801

Sodium potassium tartrate, 6381-59-5 tetrahydate

TABLE 3

Name CAS #

L-(+)-Arginine 1119-34-2 monohydrochloride

Ethylenediamine 333-18-6 dihydrochloride

Sodium formate 141-53-7

Sodium acetate 127-09-3

Potassium acetate 127-08-2

Ammonium citrate 3012-65-5

Ammonium bicarbonate 1066-33-7

Ammonium chloride 12125-02-9

Ammonium nitrate 6484-52-2

Ammonium persulfate 7727-54-0

Ammonium sulfate 7783-20-2

Zinc chloride 7646-85-7

Sulfuric acid, zinc salt 7446-20-0

(1 :1 ), heptahydrate

Sodium Tripolyphosphate 7758-29-4 ammoniuni benzoate 1863-63-4 ammonium bisulfite 10192-30-0

I,5-Naphthalenedisulfonic Acid 1655-29-4

Disodium Salt

4-Hydroxybenzoic Acid 99-96-7

Diphenylacetic Acid 117-34-0

Glutaric Acid 110-94-1

L-(-)-Fucose 2438-80-4

L-Cysteine Hydrochloride 52-89-1

L-Histidine Hydrochloride 1880304

Monohydrate o-Toluic Acid 118-90-1

Pivalic Acid 75-98-9

TABLE 3

Name CAS #

Pyruvic Acid Sodium Salt 113-24-6

Potassium bromide 2139626

Sodium Dithionate Dihydrate 7631-94-9

Sodium Malonate 141-95-7

Trisodiuin Citrate 68-04-2

Potassium Sodium Tartrate 304-59-6

Potassium Citrate 866-84-2

D-Maltose Monohydrate 6363-53-7

Cyclohexaamylose 10016-20-3

Dodecyl sulfate, lithium salt 2044-56-6

Manganese chloride 2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9

Triphosphoric acid, 13845-36-8 pentapotassium salt

Glycine ethyl ester 623-33-6 hydrochloride

L-Histidine methyl ester 7389-87-9 dihydrochloride

L-Leucine methyl ester 7517-19-3 hydrochloride

D-Lysinc hydrochloride 7274-88-6

2-Naphthalenesulfonic acid 532-02-5 sodium salt calcium nitrate tetrahydrate 13477-34-4

Vitamin B1 59-43-8

Zinc Acetate Dihydrate 5970-45-6

Potassium fluoride 7789-23-3

Potassium iodate 2139718

Potassium iodide 7681-11-0

TABLE 3

Name CAS #

Potassium thiocyanate 333-20-0

Sodium bromide 7647-15-6

Sodium fluoride 7681-49-4

Sodium iodide 7681-82-5

Sodium nitrate 7631-99-4

Calcium acetate 5743-26-0

Trichloroacetic acid 76-03-9

Ammonium acetate 631-61-8

Ammonium fluoride 12125-01-8

DL-malic acid 617-48-1 t-Butyl Alcohol 75-65-0 beta-AIanine 107-95-9

(S)-(-)-Tryptophan 73-22-3

Malonic acid 141-82-2

Phenethylamine 64-04-0

Salicylylaldehyde 90-02-8

Sodium benzoate 532-32-1

Mandelic acid 90-64-2

Calcium pantothenate 137-08-6

Chloroacetic Acid 79-11-8

Ethanol Amine 141-43-5

Salicylic acid 69-72-7

Saccharin sodium 128-44-9

Thiamine hydrochloride 67-03-8

2,2'-Oxybisethanol 111-46-6

Resorcinol 108-46-3

2-Amino-2-(hydroxymcthyl)-1 ,3- 77-86-1 propanediol

2,5-Dimethylphenol 95-87-4

Ammonium Phosphate 7722-76-1

TABLE 3

Name CAS #

Monobasic

1 ,3-Butanediol 107-88-0

Glycolic Acid 79-14-1

Sodium Gluconate 527-07-1

Terephthalic Acid 100-21-0

L-Ascorbic Acid Sodium Salt 134-03-2

3-Acetyl-6-methyl-2,4- 520-45-6 pyrandione

Calcium Acetate 62-54-4

Nicotinamide 98-92-0

1-Hydroxy-2-naphthoic Acid 86-48-6

2-lsopropylphenol 88-69-7

4-Aminosalicylic Acid 65-49-6

Calcium Glycerophosphate 27214-00-2

Erythorbic Acid Sodium Salt 7378-23-6

Gluconic Acid Potassium Salt 299-27-4

Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5

Potassium Benzoate 582-25-2

Taurine 107-35-7

Thiamine Nitrate 532-43-4

3,3,5-Trimethyl-1 -cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0

Sulfosalicylic acid 97-05-2

Gallic acid 149-91-7

L-borneol 464-45-9 lsoborneol 124-76-5

2,5-Dihydroxybenzoic acid, 490-79-9

Gentisic acid

5-hydroxy-6-methyl-3,4- 65-23-6

TABLE 3

Name CAS # pyridinedimethanol

Naphthalene-2-sulfonic acid 120-18-3

Ethanesulfonic acid, 2- 1562-00-1 hydroxy-, monosodium salt

Pamoic acid 130-85-8

2,4-Dimethylphenol 105-67-9

3,5-Dihydroxyacetophenone 51863-60-6

Eugenol 97-53-0 n-Butyric Acid 107-92-6

Hydroquinone 123-31-9

Propionic Acid 79-09-4 meta-Phenylenediamine 108-45-2

Oxalic Acid 144-62-7 n-Hexanoic Acid 142-62-1

2-Furancarboxylic Acid 88-14-2

4'-Nitroacetanilide 104-04-1

D-(-)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1

Galactaric acid 526-99-8

D-glucuronate 1700908

Lactobionic acid 96-82-2 p-Formylacetanilide 122-85-0

2-Mcrcaptobenzoic acid 147-93-3

Propanoic acid, 2-hydroxy-, 28305-25-1 calcium salt (2:1), (5)-

D(+)-10-Camphorsulfonic acid 3144-16-9

3-Cyclopentylpropionic acid 140-77-2

1 R-(-)-Camphorsulfonic acid 35963-20-3

DL-Lysine 70-54-2

Cinnamic acid 621-82-9

TABLE 3

Name CAS #

Triethanolaminc 102-71-6

Acetic Acid 64-19-7

Dichloroacctic Acid 79-43-6

Diethylamine 109-89-7

Diethylaminoethanol 100-37-8

N-(2-HydroxyethyI)Morpholine 622-40-2

Octanoic Acid 124-07-2 isobutyric acid 79-31-2

Anisic Acid 100-09-4

Betaine 107-43-7

Enanthoic Acid 111-14-8

Hippuric Acid 495-69-2

Tiglic Acid 80-59-1

Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9

D-(+)-Camphoric acid 124-83-4

N-(2-Hydxoxyethyl)pyrrolidine 2955-88-6

Name_ CAS #

Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate 7558-79-4

Sodium Phosphate Monobasic 7558-80-7

Sodium thiosulfate 7772-98-71

Orthoboric acid 10043-35-3

Diethanolamine 111-42-2

Benzaldehyde 100-52-7

Sorbic acid 110-44-1

L-(+)-Tartaric Acid 87-69-4

D-mannitol 69-65-8

Butyl paraben 94-26-8

Thymol 89-83-8

TABLE 3

Name CAS #

Methyl salicylate 119-36-8

Citric acid 77-92-9

Creatinine 60-27-5

Vitamin C 50-81-7

Benzoic Acid 65-85-0

Methyl 4-hydroxybenzoate 99-76-3

Name CAS # in-Cresol 108-39-4 p-Cresol 106-44-5

Aspirin 50-78-2

Phenol 108-95-2

Sucrose 57-50-1

Potassium citrate, monohydrate 1534146

Sodium acetate 127-09-3

Lactic acid 50-21-5

Propionic acid, sodium salt 65-85

Benozyl alcohol 100-51-6

Phenethyl alcohol 60-12-8

Cholesterol 57-88-5

D-Glucose 50-99-7

Sorbitol 50-70-4

Aspartame 22839-47-0

Saccharin 81-07-2

2,6-Di-tert-Butyl-p-Cresol 128-37-0

4-ChIoro-3-methylphenol 59-50-7 glycerin 56-81-5

Propyl paraben 94-13-3 fu marie acid 110-17-8 dabco 280-57-9 p-Phenylenediamine 106-50-3

TABLE 3

Name CAS #

Anethole 4180-23-8 propyl gallate 121-79-9

L-monosodium glutamate 142-47-2

Butylated hydroxyanisole 25013-16-5

Cyclohexanol, 5-methyl-2-(1- 89-78-1 methylethyl)-,

(1 alpha, 2beta, δalpha)- alpha-Thioglycerol 96-27-5

Sodium dehydroacetate 4418-26-2

Ethyl 4-hydroxybenzoate 120-47-8

Ethyl Vanillin 121-32-4

Triacetin 102-76-1

Potassium sorbate 590-00-1

Triethyl citrate 77-93-0

(S)-(+)-Arginine 74-79-3

Glycine 56-40-6

(S)-(-)-Histidine 71-00-1

(S)-(+)-Lysine 56-87-1

Quinone 106-51-4

Naphthalene, 2-ethoxy- 93-18-5

Methanesulfonic Acid 75-75-2

DL-Tartaric Acid 133-37-9

Cyclamic acid 100-88-9

(S)-(-)-Phenylalanine 63-91-2

(S)-(-)-Tyrosine 60-18-4

Carvone 99-49-0

Ethyl butyrate 105-54-4

6-Methyl-5-hepten-2-one 110-93-0

Ethyl acetoacetate 141-97-9

Methyl benzoate 93-58-3

TABLE 3

Name CAS #

Phenylacetic Acid 103-82-2

Adipic acid 124-04-9

Ethyl benzoate 93-89-0

Benzyl benzoate 120-51-4

Pyruvic acid 127-17-3

Succinic acid 110-15-6

Indole 120-72-9

Methyl anthranilate 134-20-3

Diethyl malonate 105-53-3

Niacin 59-67-6

Meso-inositol 87-89-8

4-Aminobenzoic acid 150-13-0

Anisole 100-66-3

Urea 57-13-6

Pyrrolidine 123-75-1

Cyclopentanone 120-92-3

Acetic anhydride 108-24-7

Benzophenone 119-61-9

D-(-)-Fructose 57-48-7

D-(+)-Xylose 58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethyl isovalerate 108-64-5

1 ,1 '-Azobisformamide 123-77-3

6-Methylcourmarin 92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2

Cymene 99-87-6

Dimethyl succinate 106-65-0 p-Anisaldehyde 123-11-5

TABLE 3 Name CAS #

Phenyl ether 101-84-8

Tetrahydro-2-furanmethanol 97-99-4

Valeric Acid 109-52-4

3,4-xylenol 95-65-8

1 ,1-diethoxyethane 105-57-7 ethyl butyraldehyde 97-96-1

Ethyl crotonate 623-70-1 ethyl isobtyrate 97-62-1 methyl isovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde 123-15-9

4-(2,6,6-Trimethyl-2-cyclohexen- 127-41-3

1-yi)-

3-buten-2-one

4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1 -yl)-3-buten-2-one

Maleic acid 110-16-7

3-Methylbutanoic acid 503-74-2

L-Glutamic Acid 56-86-0

D-limonene 5989-27-5

1-Penyl-1-proponal 93-54-9

2'-Hydroxyacetophenone 118-93-4

2,4-Dihydroxybenzoic Acid 89-86-1

2-Phenyl-1-propanol 1123-85-9

3-Phenylpropionic Acid 501-52-0

4-Ethoxyphenol 622-62-8

Alpha-Terpineol 98-55-5

Bensaldehyde Dimethylacetal 1125-88-8

Benzyl Ether 103-50-4

Benzyl Formate 104-57-4

TABLE 3

Name CAS #

Benzyl Salicylate 118-58-1

Cinnamyl Alcohol 104-54-1

D-(+)-Glucono-1 ,5-lactone 4253-68-3

D-lsoascorbic Acid 89-65-6

2,3-Naphthalenediol 92-44-4

Diethyl Succinate 123-25-1

Ethyl 2-Aminobenzoate 87-25-2

Ethyl Cinnamate 103-36-6

Ethyl Phenylacetate 101-97-3

Ethyl Salicylate 118-61-6 gamma-Valerolactone 108-29-2 hydroquinone Dimethyl Ether 150-78-7 lsocapriic Acid 646-07-1 lsoeugenol 97-54-1 lsopropyl Benzoate 939-48-0

L-(+)-lsoleucine 73-32-5

L-MaNc acid 97-67-6

L-2-Aminopropionic Acid 56-41-7

L-Carnitine 541-15-1

L-Glutamine 56-85-9

L-Hydroxyproline 51-35-4

L-Proline 147-85-3

L-Serine 56-45-1

L-Threonine 72-19-5

L-Valine 72-18-4

Phenoxyacetic Acid 122-59-8

Veratrole 91-16-7

2-Ethylbutyric acid 88-09-5

2-Methylpyyrazine 109-08-0 o-methoxybenzaldehyde 135-02-4

TABLE 3

Name CAS #

L-Leucine 61-90-5

L-Asparagine 70-47-3 propiophenone 93-55-0

5-isopropyl-2-methyl-phenol 499-75-2

Xylitol 87-99-0 ethyl 4-oxopentancoate 539-88-8 methyl cinnamate 103-26-4 cumic alcohol 536-60-7 methl 2-naphthyl ketone 93-08-3

1 -methyl-1 -(1 -methylethyl)- 99-85-4

1 ,4-Cyclohexadiene en -ethylene diamine

Caffeine 58-08-2

5-methylfurfural 620-02-0 furfuryl acetate 623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-1

4'-Methoxyacetophenone 100-06-1

D-Fenchome 4695-62-9

1 -Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5

Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenome 122-00-9

Methyl phenylacetate 101-41-7

4-Ethoxybenzaldehyde 10031-82-0 p-tolyl acetate 140-39-6

2,6-Dimethoxyphenol 91-10-1

Methyl 2-methoxybenzoate 606-45-1 alpha-methylcinnamaldehyde 101-39-3

TABLE 3

Name CAS #

2-methoxycinnamaldehyde 60125-24-8

Potassium bicarbonate 298-14-6 piperonyl acetate 326-61-4

2,3-hexanedione 3848-24-6 furfural acetone 623-15-4 trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9

Methyl nicotinate 93-60-7

Ethyl benzoylacetate 94-02-0

Methyl 4-methoxybenzoate 121-98-2

Levulinic acid 123-76-2 m-Dimethoxybenzene 151-10-0

2-acetyipyridine 1122-62-9 tetramethyl-pyrazine 1124-11-4

2,3-dimethyl-pyrazine 5910-89-4 trimethyl-pyrazine 14667-55-1

2-ethyl-3-methyl-pyrazine 15707-23-0

5-Methyl-3H-furan-2-one 591-12-8

2-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-0

2-Methoxy-4-propylphenol 2785-87-7

Naphthalene,2-(2- 2173-57-1 methylpropoxy)-

2-Acetyl-1 -methylpyrrole 932-16-1

3,3-Dimethylacrylic acid 541.47.9

Ethyl sorbate 2396-84-1

4-(4-Hydroxyphenyl)-2-butanone 5471-51-2

4-Methoxyphenylacetone 122-84-9

(-)-Myrtenal 564-94-3

3-Phenylpropionaldehyde 104-53-0

TABLE 3 Name CAS #

1-Phenylethyl propionate 120-45-6

2-Methyltetrahydrofuran-3-one 3188-00-9

Cinnamyl acetate 103-54-8

Styrallyl acetate 93-92-5

Ethyl 4-methoxybenzoate 94-30-4

Benzyl propionate 122-63-4

Phenylpyruvate 156-06-9 furaneol 3658-77-3 methyl 2-methylbutanoate 868-57-5

Benzeneacetaldehyde, alpha- 93-53-8 methyl-

Dimethyl anthranilate 85-91-6

1 ,1-Dimethoxy-2-phenylpropane 90-87-9

4-hexanolide 695-06-7

Dimethylbenzylcarbinyl acetate 151-05-3

Benzyl isobutyrate 103-28-6

Acetyl isoeugenol 93-29-8

2-Acetyl-5-methyl furan 1193-79-9

Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehyde

Benzylcarbinyl formate 104-62-1 p-Cresyl alpha-toluate 101-94-0

Potassium bisulfate 7646-93-7

Potassium carbonate 584-08-7

Postassium chloride 7447-40-7

Potassium hydroxide 1310-58-3

Ethyl tiglate 5837-78-5

Nerol oxide 1786-08-9

DL-Tetrohyd rof u rf u ryl 637-65-0 propionate

TABLE 3

Name CAS #

Benzaldehyde propylene glycol 2568-25-4 acetal

2-Methyl-3-(2-furyl) acrolein 874-66-8 vanillin 121-33-5

Cholic acid 81-25-4

R-Carvone 6485-40-1

Potassium nitrate 7757-79-1

Potassium permanganate 7722-64-7

Potassium persulfate 7727-21-1

Postassium phosphate, dibasic 2139900

Potassium Phosphate 7778-77-0

Monobasic

Potassium sulfate 7778-80-5

Sodium bicarbonate 144-55-8

Sodium bisulfite 7631-90-5

Sodium carbonate 497-19-8

Sodium chloride 7647-14-5

Sodium dithionite 7775-14-6

Sodium hydroxide 1310-73-2

Sodium nitrite 7632-00-0

Sodium Pyrophosphate 7722-88-5

Sodium sulfate 7757-82-6

Sodium sulfite 7757-83-7

Sodium thiocyanate 540-72-7

Calcium Carbonate 471-34-1

Calcium chloride 10043-52-4

Calcium gluconate 299-28-5

Calcium hydroxide 1305-62-0

Calcium phosphate, dibasic 7757-93-9

Calcium sulfate 7778-18-9

TABLE 3

Name CAS #

N-Methyl-D-glucamine 6284-40-8

Calcium oxide 1305-78-8

Calcium Phosphate Monobasic 7758-23-8

Magnesium chloride 7791-18-6 hexahydrate

Magnesium sulfate 7487-88-9

Magnesium Sulfate 10034-99-8

Heptahydrate

Aluminum chloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2

Aluminum potassium sulfate, 7784-24-9 dodecahydrate

Aluminum sulfate, 7784-31-8 octadecahydrate

(S)-(-) Cysteine 52-90-4 p-Toluenesulfonic Acid 104-15-4

Potassium bitartrate 868-14-4

DL-aspartic acid 617-45-8 p-Dimethylaminobenzaldehyde 100-10-7

Sodium salicylate 54-21-7

Benzoin 119-53-9

Sodium dodecyl sulfate 151-21-3

L-Menthol 2216-51-5

Tiron 149-45-1

Riboflavin 83-88-5

Sodium Acetate Trihydrate 6131-90-4

Disodium Succinate 6106-21-4

Hexahydrate

Disodium 6381-92-6 ethylenediaminetetraacetate

TABLE 3

Name CAS # d i hydrate sodium citrate, dihydrate 1545801

Sodium potassium tartrate, 6381-59-5 tetrahydrate

L-(+)-Arginine 1119-34-2 monohydrochloride

Ethylenediamine 333-18-6 dihydrochloride

Sodium formate 141-53-7

Sodium acetate 127-09-3

Potassium acetate 127-08-2

Ammonium citrate 3012-65-5

Ammonium bicarbonate 1066-33-7

Ammonium chloride 12125-02-9

Ammonium nitrate 6484-52-2

Ammonium persulfate 7727-54-0

Ammonium sulfate 7783-20-2

Zinc chloride 7646-85-7

Sulfuric acid, zinc salt 7446-20-0

(1 :1 ), heptahydrate

Sodium Tripolyphosphate 7758-29-4 ammonium benzoate 1863-63-4 ammonium bisulfite 10192-30-0

1 ,5-Naphthalenedisulfonic Acid 1655-29-4

Disodium Salt

4-Hydroxybenzoic Acid 99-96-7

Diphenylacetic Acid 117-34-0

Glutaric Acid 110-94-1

L-(-)-Flucose 2438-80-4

L-Cysteine Hydrochloride 52-89-1

TABLE 3

Name CAS #

L-Histidine Hydrochloride 1880304

Monohydrate o-Toluic Acid 118-90-1

Pivalic Acid 75-98-9

Pyruvic Acid Sodium Salt 113-24-6

Potassium bromide 2139626

Sodium Dithionate Dihydrate 7631-94-9

Sodium Malonate 141-95-7

Trisodium Citrate 68-04-2

Potassium Sodium Tartrate 304-59-6

Potassium Citrate 866-84-2

D-Maltose Monohydrate 6363-53-7

Cyclohexaamylose 10016-20-3

Dodecyl sulfate, lithium salt 2044-56-6

Manganese chloride 2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9

Triphosphoric acid, 13845-36-8 pentapotassium salt

Glycine ethyl ester 623-33-6 hydrochloride

L-Histidine methyl ester 7389-87-9 dihydrochloride

L-Leucine methyl ester 7517-19-3 hydrochloride

D-Lysine hydrochloride 7274-88-6

2-NaphthaIenesulfonic acid 532-02-5 sodium salt calcium nitrate tetrahydrate 13477-34-4

Vitamin B1 59-43-8

TABLE 3

Name CAS #

Zinc Acetate Dihydrate 5970-45-6

Potassium fluoride 7789-23-3

Potassium iodate 2139718

Potassium iodide 7681-11-0

Potassium thiocyanate 333-20-0

Sodium bromide 7647-15-6

Sodium fluoride 7681-49-4

Sodium iodide 7681-82-5

Sodium nitrate 7631-99-4

Calcium acetate 5743-26-0

Trichloroacetic acid 76-03-9

Ammonium fluoride 631-61-8

DL-malic acid 12125-01-8 t-Butyl Alcohol 617-48-1 beta-Alanine 75-65-0

(S)-(-) Tryptophan 107-95-9

Malonic acid 141-82-2

Phenethylamine 64-04-0

Salicylylaldehyde 90-02-8

Sodium benzoate 532-32-1

Mandelic acid 90-64-2

Calcium panthothanate 137-08-6

Chloroacetic Acid 79-11-8

Ethanol Amine 141-43-5

Salicyclic acid 69-72-7

Saccharin sodium 128-44-9

Thiamine hydrochloride 67-03-8

2,2'-oxybisethanol 111-46-6

Resorcinol 108-46-3

2-Amino-2-(hydroxymethyl)-1 ,3- 77-86-1

TABLE 3

Name CAS # propanediol

2,5-Dimethylphenol 95-87-4

Ammonium Phosphate 7722-76-1

Monobasic

1 ,3-Butanediol 107-88-0

Glycolic Acid 79-14-1

Sodium Gluconate 527-07-1

Terephthalic Acid 100-21-0

L-Ascorbic Acid Sodium Salt 134-03-2

3-Acetyl-6-methyl-2,4- 520-45-6 pyrandione

Calcium Acetate 62-54-4

Nicotinamide 98-92-0

1-Hydroxy-2-naphthoic Acid 86-48-6

2-lsopropylphenol 88-69-7

4-Aminosalicyciic Acid 65-49-6

Calcium Glycerophosphate 27214-00-2

Erythorbic Acid Sodium Salt 7378-23-6

Gluconic Acid Potassium Salt 299-27-4

Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5

Potassium Benzoate 582-25-2

Taurine 107-35-7

Thiamine Nitrate 532-43-4

3,3,5-Timethyl-1 -cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0

Sulfosalicyclic acid 97-05-2

Gallic acid 149-91-7

L-borneol 464-45-9 lsoborneol 124-76-5

TABLE 3

Name CAS #

2,5-Dihdroxybenzoic acid, 490-79-9

Gentisic acid

5-hyd roxy-6-methyl-3 ,4- 65-23-6 pyridinedimethanol

Naphthalene-2-sulfonic acid 120-18-3

Ethanesulfonic acid, 2-hydroxy-, 1562-00-1 monosodium salt

Pamoic acid 130-85-8

2,4-Dimethylphenol 105-67-9

3,5-Dihydroxyacetophenone 51863-60-6

Eugenol 97-53-0 n-Butyric Acid 107-92-6

Hydroquinone 123-31-9

Propionic Acid 79-09-4 meta-Phenylenediamine 108-45-2

Oxalic Acid 144-62-7 n-Hexanoic Acid 142-62-1

2-Furancarboxylic Acid 88-14-2

4'-Nitroacetanilide 104-04-1

D-(-)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1

Galactaric acid 526-99-8

D-glucuronate 1700908

Lactobionic acid 96-82-2 p-Formylacetanilide 122-85-0

2-Mercaptobenzoic acid 147-93-3

Propanoic acid, 2-hydrox-, 28305-25-1 calcium salt (2:1), (S)-

D(+)-10-Camphorsulfonic acid 3144-16-9

3-Cyclopentylpropionic acid 140-77-2

TABLE 3

Name CAS #

1 R-(-)Camphorsulfonic acid 35963-20-3

DL-Lysine 70-54-2

Cinnamic acid 621-82-9

Triethanolamine 102-71-6

Acetic Acid 64-19-7

Dichloroacetic Acid 79-43-6

Diethylamine 109-89-7

Diethylaminoethanol 100-37-8

N-(2-Hydroxyethyl)Morpholine 622-40-2

Octanoic Acid 124-07-2 isobutyric acid 79-31-2

Anisic Acid 100-09-4

Betaine 107-43-7

Enantoic Acid 111-14-8

Hippuric Acid 495-69-2

Tiglic Acid 80-59-1

Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9

D-(+)-Camphoric acid 124-83-4

N-(2-Hydroxyethyl)pyrrolidine 2955-88-6

Ionic guests are salts themselves, and may be formed from bases and acids prior to being used to form cocrystals. For example, the following bases and acids may be reacted to form ionic guests: Bases

Ammonia

L-Arginine

Benethamine

Benzathine

Betaine

Calcium Hydroxide Choline Deanol

Diethanolamine Dietbylamine 2-(Diethylamino)ethanol 2-Aminoethanol Ethylenediamine N-Methylglucamine Hydrabamine 1 H-lmidazole Lysine

Magnesium Hydroxide Morpholine

4-(2-Hydroxyethyl)Morpholine Piperazine

Potassium Hydroxide Pyrrolidine

1 -(2-Hydroxyethyl)Pyrrolidine Sodium Hydroxide Triethanolamine Tromethamine Zinc Hydroxide Acids

(+)-L-Tartaric Acid

1 ,2,2-Trimethyl- 1 ,3-cyclopentanedicarboxylic Acid lO-Undecylenic Acid

1 -Hydroxy-2-naphthoic Acid

(+)-Camphor- IO-sulfonic Acid

2,5-Dihydroxybenzoic Acid

2-Furancarboxylic Acid

2-Mercaptobenzoic Acid

3-Cyclopentylpropionic Acid

3-Phenylpropionic Acid

4-Aminosalicylic Acid

4-Hydroxybenzoic Acid

Acetic Acid

Adipic Acid alpha-Hydroxypropionic Acid

Benzenesulfonic Acid

Benzoic Acid

Carbonic Acid

Cholic Acid

Citric Acid

(-)-D-Tartaric Acid

(+)-D-Camphoric Acid

(+)-D-Malic Acid

(+)-L-Malic Acid

2,2-Dichloroacetic Acid

DL- 10-Camphorsulfonic Acid

DL-Glutamic Acid

DL-MaNc Acid

DL-Tartaric Acid

Dodecylsulfuric Acid

Ethanesulfonic Acid

Ethylenediaminetetraacetic Acid

Ethylsulfuric Acid

Fu marie Acid

Galactaric Acid

Gallic Acid

Gluconic Acid

Glutaric Acid

Glycolic Acid

Hippuric Acid

Hydriodic Acid

Hydrobromic Acid

Hydrochloric Acid (-)-L-Apple Acid (í)-L-Lactic Acid (+)-L-Tartaric Acid D,L-I_actic Acid Lactobionic Acid L-Aspartic Acid Laurie Acid L-GIutamic Acid Maleic Acid (-)-L-Malic Acid Malonic Acid D,L-Mandelic Acid Methanesulfonic Acid Naphthalene-2-sulfonic acid n-Butyric Acid n-Decanoic Acid n-Hexanoic Acid Nitric acid n-Tetradecanoic Acid Octanoic Acid Oleic Acid Orotic Acid Orthoboric Acid Oxalic Acid

4-Acetamidobenzoic Acid Palmitic Acid Pamoic Acid Phosphoric Acid Picric Acid Pivalic Acid Propionic Acid p-Toluenesulfonic Acid

Pyrophosphoric Acid

Salicylic Acid

Stearic Acid

Succinic Acid

Sulfosalicylic Acid

Sulfuric Acid

Terephthalic Acid

Thiocyanic Acid

Valeric Acid

Valproic Acid

Typically, suitable guests will have complementary ability to noncovalently bond to the active agent or its salt, for example the ability to form hydrogen bonds with the active agent or its salt. Suitable guests for active agents having negative counterions include, but are not limited to, compounds having alcohol, ketone, ester, and/or carboxylic acid functionalities. Suitable guests may include organic acids, organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganic compounds, aliphatic esters and ketones, and aromatic esters and ketones.

In one embodiment of the disclosure, guests are neutral and not liquids at room temperature. Also among the presently preferred neutral guests are carboxylic acids having at least three carbon atoms, alternatively at least four carbon atoms, and which do not form solvates. For example, if the following acids were combined with active agents, the combination would more properly be considered a solvate than a cocrystal: acetic acid, propionic acid, and butyric acid. However, in certain embodiments of the present invention (for example, in certain cocrystals, cocrystallization methods, and screening methods), the use of solvents and solvates may still be desirable, and the use of solvents and solvates is not excluded from the scope of any cocrystal or method except where explicitly stated.

Examples of further emobodiments of the disclosure described herein are indicated below without, however, being limiting in nature. Example 1

Five cocrystals of 2-4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4- carboxamide (Compound 1) were identified by using techniques of the disclosure.

Compound 1 possesses extremely low solubility characteristics (<0.1 μg/ml_) in aqueous systems. Although the permeability of Compound 1 could not be measured in Caco-2 cells because of its inherently low solubility, Compound 1 is suspected to be a Class Il compound (low solubility and high permeability) as described in the biopharmaceutical drug classification scheme (BCS) (Amidon, Gordon L., Lennernaes, Hans, Shah, Vinod P. and Crison, John R. (1995) "A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability" Pharmaceutical Research 1990, 12(3), 4 13- 20). The calculated octanol/water partition coefficient (clogP) for Compound 1 is 2.9, supporting this suspicion (Yazdanian, Mehran, Glynn, Susan L., Wright, James L., and Hawi, Amale. (1998) "Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds" Pharmaceutical Research 1998 15(9), 1490-1494). As expected with Class Il BCS compounds, Compound 1 showed low in-vitro dissolution and low in-vivo plasma concentrations after oral dosing of the crystalline solid in dogs. Cocrystallization techniques were used as a tool to improve the pharmaceutical properties of Compound 1. Physico-chemical Characterization of Parent Compound 1 and Cocrystal 2: Differential scanning calorimetry (DSC) was performed with a PerkinElmer, Pyris 1 DSC. Each DSC sample was sealed in a 50 μl_ aluminum pan with a pierced lid and heated through the respective melting temperatures at scan rates of 10 °C/min. Modulated DSC was performed with a TA Instruments 2920 DSC. The amorphous glass of Compound 1 was prepared by heating at 10 °C/min to 220 ⁰ C and then quickly cooling to — 50 ⁰ C. The glass was then heated using a modulation amplitude of± 0.80 ⁰ C and a 60 second period with an underlying heating rate of 1 ^o C/mm. from 25 through 100 ⁰ C. X-ray powder diffraction (XRPD) patterns were collected on a Philips Analytical X'Pert Plus MPD x-ray diffractometer using a Cu tube at 5OkV and 4OmA. The scan range was 4-40 °20 with a step size of 0.02 °20/sec and the time per step of 1 second. A Surface Measurement Systems DVS- I000 was used for dynamic water sorption characterization. The sample was dried under nitrogen at 0% RH, 25 ⁰ C until the sample met equilibration conditions of less than 0.0001% weight change. The sample was cycled twice in 5% RH steps from 0 through 95% RH. Cocrystal screening:

Thermal microscopy methods were used to determine if a particular carboxylic acid was able to cocrystallize with Compound 1 using melt or highly saturated solution conditions. A total of 26 carboxylic acids were screened using a binary-melt technique (Kofler) on a microscope slide with mixture occurring by use of a coverslip (at the interface where the compounds mix, a molecular complex containing both components may form under appropriate conditions.) High boiling organic liquids such as methyl salicylate or methyl benzoate were used to create highly concentrated solutions in which the melting point of Compound 1 was reduced. By varying the liquid composition and concentration of each component before they were mixed, the conditions of an individual experiment could be tailored to match the particular guest being tested. A positive interaction was determined visually by observing the slide through crossed polars. In a negative interaction, the mixing of the guest and Compound 1 created a eutectic where no crystallization occurred while a positive interaction produced crystalline material at the binary interface. The products were analyzed by Raman spectroscopy. Five cocrystals were identified using this technique. A cocrystal of Compound 1 with glutaric acid was selected for further development. This cocrystal is referred to as Cocrystal 2. Thermal microscopic images were acquired using transmitted light and crossed polars on a microscope stage with temperature control.

Figure 2 shows a solution of Compound 1 dissolved in a small amount of methyl benzoate on a glass microscope slide. A solution of glutaric acid in methyl benzoate was also generated on the same slide approximately 1 cm away from the solution of Compound 1. A coverslip was applied to both solutions simultaneously, causing the two solutions to meet at an interface where they mixed by diffusion. The solutions were allowed to cool and solids were observed growing in the solution. In image (a) the solution of glutaric acid, the guest, is located in the bottom half of images. It has solidified as two domains (one bright and one darker) with a feather- like morphology. In that image, the solution of the API appears to grow solids in the top right corner of image. The interface where the two solutions have mixed is where cocrystal formation has occurred (the cocrystal is located on the edge of the guest solid domains and is bordered by the dark liquid phase). Liquid phases are dark in the images because the slide photograph was taken through crossed polarizing filters. Crystal growth on the slide was manipulated by adjusting the

temperature. In images (a), (b),and (c) the cocrystal (curved line in center) shows an increasing amount of growth at the boundary of the glutaric acid domain as the crystal growth progresses from (a) to (b) to (c). The growth of the cocrystal and the API are inhibited in the eutectic area that immediately separates them as shown in image (c).

The formation of the eutectic is temperature sensitive. At temperatures near the melting point of the solids, the eutectic forms in areas where the presence of the mixture of components acts to lower the melting point of the solids. The melting point is higher in areas where the solid is in equilibrium with a solution containing a higher percentage of the components (or a high percentage of the correct ratio of components) that make up the solid. A eutectic also has formed between glutaric acid and the cocrystal. In image (d) a narrow eutectic has formed as the temperature approaches the melting point of glutaric acid. In image (e) the glutaric acid has completely melted, clearly showing the boundary of the cocrystal solid phase. When the temperature was lowered again as shown in image (I), the glutaric acid grew in and formed a eutectic with the cocrystal phase. Synthesis of glutaric acid cocrystal 2 by solution methods:

Compound 1 (2.898 g, 8.431 mmol) and glutaric acid (1.111 g, 8.410 mmol) were dissolved in 150 ml_ of boiling chloroform with stirring. The solution was concentrated by continued boiling until the volume was 50 mL Seeds of the cocrystal generated in thermal experiments or from previous batches were introduced to the hot solution (spontaneous nucleation under these conditions always resulted in the stable form of Compound 1 ). Crystallization occurred rapidly and was allowed to proceed as the solution cooled over approximately 15 minutes. Approximately 100 mL of cyclohexane were added and the resulting solution was cooled on ice for 30 minutes. Cocrystal 2 was isolated by filtration and allowed to dry in the air (3.705 g, 92% yield). A single crystal was isolated from the recovered product and used in the single crystal x-ray diffraction study. Raman spectroscopy:

Raman spectra were collected with a Chrome Sentinel dispersive Raman unit equipped with a 785 nm, 7OmW excitation laser and a TE cooled CCD (1024 x 256 pixels,< 0.Ie - /pixel/sec). A fiber-optically coupled filtering probe was used to collect data in the spectral range 125cm ^"1 to 2200 cm ^"1 at a resolution of 4 cm ^"1 . Each

spectrum is a result of two co-added 20 second scans. The unit has continuous automatic calibration using an internal standard. The data were collected by SentinelSoft data acquisition software and processed in GRAMS/AI V.7. Single crystal x-ray diffraction (SCXRD):

A suitable crystal of Compound 2 was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuK _α (1.54178 A) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wl 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wl 53711-5373). The final cell parameters were determined from least-squares refinement on 3625 reflections. The structure was solved using Direct methods and difference Fourier techniques (SHELXTL, VS. 10) (SHELXTL VS. 10, 1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wl 53711- 5373). All the hydrogen atoms were located from difference Fouriers and included in the final cycles of least squares with isotropic Uy's. All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from the International Tables for X-ray Crystallography (A. J. C. Wilson (ed), "International Tables for X-ray Crystallography, Volume C" Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219- 222).). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software. Chemical and Physical Stability of Cocrvstal 2:

Samples of cocrystal 2 were placed in glass bottles at 40 °C/75% RH and 60 ⁰ C and tested periodically during two months storage. Samples were tested by XRPD, DSC, and assayed for impurities using a high performance liquid chromatography technique with ultraviolet detection (HPLC-UV) method. Cocrystal 2 was also shown to be chemically and physically stable for storage under stress conditions of 40 °C/75% relative humidity (RH) and 60 ⁰ C for two months.

Intrinsic Dissolution Studies:

Intrinsic dissolution measurements were performed using a fiber optic probe (Delphian® type 11 A fiber optic workstation, baseline correction mode with sample wavelength maximum of 279 nm and baseline wavelength of 350 nm) at 37 ⁰ C and 100 rpm in a USP apparatus Il dissolution vessel (Vankel VK7010) containing 500 ml_ of pure water. Disks 0.8 cm diameter were compressed using 70 mg of solid in stainless steel dies (Vankel Woods apparatus) at 1000 lbs for 60 seconds with a Carver Press. Dissolution studies for cocrystal 2 lasted 90 minutes, after which time the disks were recovered, carefully ground and checked by XRPD for the presence of cocrystal. Due to the low solubility of Compound 1 , dissolution studies were run over 24 hours in order to get a measurable rate. Pharmacokinetic Evaluation:

A study was conducted to compare the pharmacokinetic profiles of Compound 1 and Cocrystal 2. Compound 1 and Cocrystal 2 were administered as neat solids to six male beagle dogs in a crossover study with a two-week washout period between treatments. Each dog was dosed with either Compound 1 or Cocrystal 2 in a gelatin capsule after an overnight fast. All research involving animal subjects adhered to the "Principles of Laboratory Animal Care" (NIH publication #85-23). Dose levels of 5 mg/kg and 50 mg/kg were each evaluated. Each dog received one size #2 capsule for the 5 mg/kg dose. Dosing at 50 mg/kg required use of two size #00 capsules for each dog. Blood samples were collected at intervals for 36 hours post-dose. Non- compartmental pharmacokinetic metrics were determined using WinNonlin v. 1.5 (Scientific Consulting, Inc., Mountain View, CA). The area under the plasma concentration-time curve (AUC) was estimated by application of the linear trapezoidal rule. Statistical analyses were conducted using Microsoft Excel 2000; statistical significance was considered when p <0.05. The glutaric acid cocrystal 2 showed an eighteen times greater intrinsic dissolution rate and three times the plasma area-under-the-curve (AUC) as compared to Compound 1 in single dose dog exposure study. Particle Size Evaluation:

Particle size of each of the lots of Compound 1 and Cocrystal 2 dosed in the pharmacokinetic studies were characterized using an instrumented light scattering particle sizer (Malvern 2000). Samples from each lot were suspended in Millipore

deionized water with S drops of Triton X-100 in 2 liters included as a dispersant. Samples were analyzed in the particle-in-liquid mode. Example 2:

A cocrystal screen was performed on theophylline ("api") with a series of guest compounds. Theophylline was dissolved in ethylene glycol at ~ 1 :3 wt/wt api:solvent. This produced a melting point depression effect that effectively lowered the melting point of theophylline from 272 ⁰ C to about 135 ⁰ C to 140°C. Theophylline crystallized rapidly from the hot ethylene glycol solution on a slide under a coverslip. The guests were most often used neat (no ethylene glycol), but ethylene glycol was used if the melting point of the guest was higher than about 140 ⁰ C or if decomposition or sublimation occurred upon melting the pure guest. This technique was confirmed as being functional by testing for a known cocrystal of theophylline and p-nitro phenol.

One to three slides were prepared for each guest compound. A spatula of guest compound was placed on the slide and melted with a heat gun or the hotstage. Two large drops of a preheated solution of theophylline in ethylene glycol were placed 1 cm from the guest and both drops were covered with a large coverslip. The boundary where the solutions merged was examined under a stereo microscope using transmitted light and crossed polars. The eutectic was cycled by heating and cooling in order to help detect and promote cocrystal formation. Salicylic acid, p- hydroxybenzoic acid, sorbic acid, 1-hydroxy-2-naphthoic acid, glycolic acid, and 2,5- dihydroxybenzoic acid were all tested as guest compounds and in each, a cocrystal formation had occurred. Raman spectra of the pure guest acid, theophylline, and the cocrystal were obtained and compared to confirm cocrystal formation.