Title:
COLCHICINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2011/021397
Kind Code:
A1
Abstract:
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halogen atom, a hydroxyl group, a nitro group, an amino group, or a mono-, di- or tri-fluoromethyl group; R2, R3 and R4 are each a methoxy group or a hydroxyl group, or alternatively R2 and R3, or R3 and R4 together represent a methylenedioxy group; R5 and R6 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, an arylalkyl group, a C2-6 alkenyl group, -COR7, -COOR8, -SO2R9, -CONR10R11, or -CSNR12R13, or alternatively R5 and R6 together with the nitrogen atom to which R5 and R6 are bonded may form a three- to seven-membered cyclic amino group; R7 is a C1-6 alkyl group or the like; R8 is a C1-6 alkyl group or the like; R9 is a C1-6 alkyl group or the like; R10 and R11 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, or the like; and R12 and R13 may be the same or different and are each a hydrogen atom, an alkyl group, or the like.
Inventors:
TAKAYAMA HIROMITSU (JP)
YASOBU NAOKO (JP)
KITAJIMA MARIKO (JP)
YAEGASHI TAKASHI (JP)
MATSUZAKI TAKESHI (JP)
NAGAOKA MASATO (JP)
HASHIMOTO SHUSUKE (JP)
NISHIYAMA HIROYUKI (JP)
SUGIMOTO TAKUYA (JP)
ONO MASAHIRO (JP)
YASOBU NAOKO (JP)
KITAJIMA MARIKO (JP)
YAEGASHI TAKASHI (JP)
MATSUZAKI TAKESHI (JP)
NAGAOKA MASATO (JP)
HASHIMOTO SHUSUKE (JP)
NISHIYAMA HIROYUKI (JP)
SUGIMOTO TAKUYA (JP)
ONO MASAHIRO (JP)
Application Number:
PCT/JP2010/005136
Publication Date:
February 24, 2011
Filing Date:
August 20, 2010
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
YAKULT HONSHA KK (JP)
TAKAYAMA HIROMITSU (JP)
YASOBU NAOKO (JP)
KITAJIMA MARIKO (JP)
YAEGASHI TAKASHI (JP)
MATSUZAKI TAKESHI (JP)
NAGAOKA MASATO (JP)
HASHIMOTO SHUSUKE (JP)
NISHIYAMA HIROYUKI (JP)
SUGIMOTO TAKUYA (JP)
ONO MASAHIRO (JP)
YAKULT HONSHA KK (JP)
TAKAYAMA HIROMITSU (JP)
YASOBU NAOKO (JP)
KITAJIMA MARIKO (JP)
YAEGASHI TAKASHI (JP)
MATSUZAKI TAKESHI (JP)
NAGAOKA MASATO (JP)
HASHIMOTO SHUSUKE (JP)
NISHIYAMA HIROYUKI (JP)
SUGIMOTO TAKUYA (JP)
ONO MASAHIRO (JP)
International Classes:
C07C225/20; A61K31/135; A61K31/165; A61P35/00; C07C233/32; C07C233/41; C07C271/24
Foreign References:
FR1512320A | 1968-02-09 |
Other References:
PAVLOS KOUROUPIS, HANS-JURGEN HANSEN: "From Colchicine and Some of Its Derivatives to 1,2,3,9,10-Pentamethoxybenzo[a]heptalenes", HELVETICA CHIMICA ACTA, vol. 78, no. 5, 9 August 1995 (1995-08-09), pages 1247 - 1277
K. M. EL-AZONY, ET AL.: "An investigation of the 125I-radioiodination of colchicine for medical purposes", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 52, no. 1, 17 November 2008 (2008-11-17), pages 1 - 5
K. M. EL-AZONY, ET AL.: "An investigation of the 125I-radioiodination of colchicine for medical purposes", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 52, no. 1, 17 November 2008 (2008-11-17), pages 1 - 5
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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