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Patent Searching and Data


Title:
COLITIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/136942
Kind Code:
A1
Abstract:
The present invention relates to a colitis inhibitor which is safe and exhibits an excellent colitis inhibition effect, and a method for producing same. More specifically, the present invention relates to a colitis inhibitor that contains, as an active ingredient, lactic acid bacteria of the genus Lactobacillus, the lactic acid bacteria exhibiting heat shock protein (HSP) 70 expression-promoting activity in colonic cells.

Inventors:
KOBAYASHI KYOSUKE (JP)
ASAMI YUKIO (JP)
KOYAMA SATOMI (JP)
Application Number:
PCT/JP2016/055811
Publication Date:
September 01, 2016
Filing Date:
February 26, 2016
Export Citation:
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Assignee:
MEIJI CO LTD (JP)
International Classes:
A61K35/747; A61P1/04; A61P1/10; A61P43/00; C12N1/20; C12N15/09; C12R1/225
Foreign References:
JP2012502996A2012-02-02
Other References:
HIRAMATSU YUKIHIRO ET AL.: "The anti- inflammatory effects of a high-frequency oligodeoxynucleotide from the genomic DNA of Lactobacillus casei", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 23, no. 1, 2014, pages 139 - 147, ISSN: 1567-5769
ELAINE O. PETROF ET AL.: "Probiotics Inhibit Nuclear Factor-kB and Induce Heat Shock Proteins in Colonic Epithelial Cells Through Proteasome Inhibition", GASTROENTEROLOGY, vol. 127, 2004, pages 1474 - 1487, ISSN: 0016-5085
FUKUSHIMA YOICHI ET AL.: "Probiotics and Natural Defense Function of the Host", BIOSCIENCE AND MICROFLORA, vol. 26, no. 1, 2007, pages 1 - 10, XP008143493, ISSN: 1342-1441
TOSHIFUMI OKUSA ET AL.: "Nyusankin LC1 Kabu (Lactobacillus johnsonii La1) no DSS Choen ni Taisuru Hassho Yobo, Yokusei Koka", JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 102, 2005, pages A138, ISSN: 0446-6586
LIU HAO-YU ET AL.: "Effects of Lactobacillus johnsonii and Lactobacillus reuteri on gut barrier function and heat shock proteins in intestinal porcine epithelial cells", PHYSIOLOGICAL REPORTS, vol. 3, no. e12355, 2015, pages 1 - 13, ISSN: 2051-817X
Attorney, Agent or Firm:
NAGAI Hiroshi et al. (JP)
Hiroyuki Nagai (JP)
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