Title:
COLLAGEN-LIKE MODIFIED PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/075485
Kind Code:
A1
Abstract:
The present invention provides: a collagen-like modified protein that contains a trimerization domain corresponding to the coiled-coil sequence of human type II transmembrane collagen and a domain corresponding to NC11-COL7 of human BP180 and/or a domain corresponding to NC7-COL4 thereof, said domain(s) being located on the C-terminal side of the trimerization domain, provided that this collagen-like modified protein does not bind to a human autoantibody targeting NC16A of human BP180; a method and a kit for detecting a human autoantibody using the aforesaid protein; and a method and a kit for diagnosing drug-induced bullous pemphigoid using the aforesaid protein.
Inventors:
NISHIE WATARU (JP)
MAI SHOKO (JP)
MAI YOSUKE (JP)
IZUMI KENTARO (JP)
MAI SHOKO (JP)
MAI YOSUKE (JP)
IZUMI KENTARO (JP)
Application Number:
PCT/JP2021/037556
Publication Date:
April 14, 2022
Filing Date:
October 11, 2021
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07K14/78; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/62; G01N33/53
Other References:
IZUMI KENTARO, NISHIE WATARU, MAI YOSUKE, WADA MAYUMI, NATSUGA KEN, UJIIE HIDEYUKI, IWATA HIROAKI, YAMAGAMI JUN, SHIMIZU HIROSHI: "Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 136, no. 11, 1 November 2016 (2016-11-01), United States, pages 2201 - 2210, XP009535631, ISSN: 0022-202X, DOI: 10.1016/j.jid.2016.06.622
MAI YOSUKE, NISHIE WATARU, IZUMI KENTARO, SHIMIZU HIROSHI: "Preferential Reactivity of Dipeptidyl Peptidase-IV Inhibitor-Associated Bullous Pemphigoid Autoantibodies to the Processed Extracellular Domains of BP180", FRONTIERS IN IMMUNOLOGY, vol. 10, no. 1224, 29 May 2019 (2019-05-29), XP055920156, DOI: 10.3389/fimmu.2019.01224
Y MAI, W NISHIE, K IZUMI, E TOYONAGA, H IKAWA, T MORI, M BENIKO, H SHIMIZU: "313 Detection of major epitopes for autoantibodies in dipeptidyl peptidase IV inhibitors-associated bullous pemphigoid.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 138, no. 5, 1 May 2018 (2018-05-01), NL , pages S53, XP055922456, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.03.315
NISHIE WATARU: "Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics", IMMUNOLOGICAL MEDICINE, vol. 42, no. 1, 2 January 2019 (2019-01-02), pages 22 - 28, XP055922463, ISSN: 2578-5826, DOI: 10.1080/25785826.2019.1619233
MAI YOSUKE, NISHIE WATARU, IZUMI KENTARO, SHIMIZU HIROSHI: "Preferential Reactivity of Dipeptidyl Peptidase-IV Inhibitor-Associated Bullous Pemphigoid Autoantibodies to the Processed Extracellular Domains of BP180", FRONTIERS IN IMMUNOLOGY, vol. 10, no. 1224, 29 May 2019 (2019-05-29), XP055920156, DOI: 10.3389/fimmu.2019.01224
Y MAI, W NISHIE, K IZUMI, E TOYONAGA, H IKAWA, T MORI, M BENIKO, H SHIMIZU: "313 Detection of major epitopes for autoantibodies in dipeptidyl peptidase IV inhibitors-associated bullous pemphigoid.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, ELSEVIER, NL, vol. 138, no. 5, 1 May 2018 (2018-05-01), NL , pages S53, XP055922456, ISSN: 0022-202X, DOI: 10.1016/j.jid.2018.03.315
NISHIE WATARU: "Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics", IMMUNOLOGICAL MEDICINE, vol. 42, no. 1, 2 January 2019 (2019-01-02), pages 22 - 28, XP055922463, ISSN: 2578-5826, DOI: 10.1080/25785826.2019.1619233
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
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