COLLAGEN-LIKE POLYMERS WITH CELL BINDING ACTIVITY

Title:

COLLAGEN-LIKE POLYMERS WITH CELL BINDING ACTIVITY

Document Type and Number:

WIPO Patent Application WO1998052620

Kind Code:

A3

Abstract:

The invention is essentially directed to a biocompatible material comprising a bulk material which has covalently bound to a surface or surfaces thereof one or more biopolymer compounds, said biopolymer compounds comprising at least one peptoid residue. The biopolymer compounds are most preferably polymer compounds comprising the sequence of the formula (I): -(Gly-Pro-Nleu)(Y)-, wherein (y) denotes >/=9. Also disclosed is a method of binding biopolymer compounds to a bulk material, which biopolymer compounds comprise at least one peptoid residue, as well as primary amine groups, the method comprising the steps of: (a) providing aldehyde or carboxyl groups on a surface or surfaces of said bulk material; (b) reacting said primary amine groups with aldehyde or carboxyl groups to form covalent bonds.

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Inventors:

STEELE JOHN GERARD (AU)
JOHNSON GRAHAM (AU)
GOODMAN MURRAY (AU)
GRIESSER HANS JOERG (AU)
MCLEAN KEITH MICHAEL (AU)
BEUMER GERRIT JAN (AU)

Application Number:

PCT/EP1998/002857

Publication Date:

February 25, 1999

Filing Date:

May 14, 1998

Export Citation:

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Assignee:

NOVARTIS AG (CH)
COMMW SCIENT IND RES ORG (CH)
STEELE JOHN GERARD (CH)
JOHNSON GRAHAM (CH)
GOODMAN MURRAY (CH)
GRIESSER HANS JOERG (CH)
MCLEAN KEITH MICHAEL (CH)
BEUMER GERRIT JAN (CH)

International Classes:

G01N33/544; A61L27/00; A61L27/22; A61L27/34; A61L31/04; A61L31/10; C12N5/07; C12N5/071; (IPC1-7): A61L/

Domestic Patent References:

WO1997019106A2	1997-05-29
WO1993011781A1	1993-06-24

Foreign References:

EP0109061A1	1984-05-23
EP0531547A1	1993-03-17
EP0290642A1	1988-11-17

Other References:

M. GOODMAN ET AL: "Collagen-Based Structures Containing the Peptoid Residue N-Isobutylglycine (Nleu). 6. Conformational Analysis of Gly-Pro-Nleu Sequences by 1H NMR, CD, and Molecular Modeling", J.AM.CHEM.SOC, vol. 118, no. 44, 1996, USA, pages 10725 - 10732, XP002085339
SIMON R J ET AL: "PEPTOIDS: A MODULAR APPROACH TO DRUG DISCOVERY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 89, October 1992 (1992-10-01), pages 9367 - 9371, XP002036760

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