Title:
COLLAGEN STRUCTURE, AND METHOD FOR PRODUCING COLLAGEN STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2013/105665
Kind Code:
A1
Abstract:
A collagen structure characterized by comprising collagen fibers that have an average diameter of 1 to 5 μm, and having a water content of 0 to 15 (w/w)% and a collagen density of 50 to 800 mg/cm3. An acidic collagen solution is neutralized to produce collagen fibers, and then the solution is subjected to filtration or the like to produce crude collagen fibers having a collagen concentration of 12 to 50 (w/v)%. The crude collagen fibers are shaped into a predetermined shape, and the resultant product is dried, thereby producing the collagen structure. Since collagen fibers composed of associated collagen molecules is used as a material for the collagen structure, the collagen structure has excellent cell invasiveness. Further, since the collagen density in the collagen structure is equivalent to that in a collagen tissue in a living body, the collagen structure can exhibit excellent tissue regeneration performance when filled into a lost part in a living body, and therefore can be used suitably as an artificial material for regenerative medicine or the like.
Inventors:
OGURA TAKAYUKI (JP)
TANAKA KEISUKE (JP)
OHBA YASUHIRO (JP)
HATTORI SHUNJI (JP)
TANAKA KEISUKE (JP)
OHBA YASUHIRO (JP)
HATTORI SHUNJI (JP)
Application Number:
PCT/JP2013/050484
Publication Date:
July 18, 2013
Filing Date:
January 11, 2013
Export Citation:
Assignee:
NIPPI INC (JP)
International Classes:
A61L27/00; A61K8/64; A61K38/17; A61P7/04; A61P17/02; A61P19/02; A61P35/00; A61P37/02; A61P43/00
Foreign References:
| JP2010273847A | 2010-12-09 | |||
| JPH0622579B2 | 1994-03-30 | |||
| JP4681214B2 | 2011-05-11 | |||
| JPH07100B2 | 1995-01-11 | |||
| JP3221690B2 | 2001-10-22 | |||
| JP4064435B2 | 2008-03-19 | |||
| JP4251665B2 | 2009-04-08 | |||
| JP2820209B2 | 1998-11-05 | |||
| JP4671365B2 | 2011-04-13 | |||
| JP2010172247A | 2010-08-12 | |||
| JPH0622579B2 | 1994-03-30 | |||
| JP4681214B2 | 2011-05-11 | |||
| JPH07100B2 | 1995-01-11 | |||
| JP3221690B2 | 2001-10-22 | |||
| JP4064435B2 | 2008-03-19 | |||
| JP4251665B2 | 2009-04-08 | |||
| JP2820209B2 | 1998-11-05 | |||
| JP4671365B2 | 2011-04-13 | |||
| JP2010172247A | 2010-08-12 |
Other References:
See also references of EP 2803371A4
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
Download PDF:
Claims: