Title:
COLLAGEN TYPE III PRODUCTION PROMOTER
Document Type and Number:
WIPO Patent Application WO/2016/084935
Kind Code:
A1
Abstract:
It has been discovered that a peptide containing an amino acid sequence represented by formula (1), (2), (3) or (4) below and having a total number of amino acid residues of 200 or less, exhibits the effect of promoting the production of collagen type III. Consequently, the present invention provides a collagen type III production promoter containing said peptide or a pharmaceutically acceptable salt thereof. Furthermore, the present invention provides a cosmetic, a quasi-drug and a drug containing said collagen type III production promoter. (1) X1-X2-Val-Tyr-X5-X6 (where X1, X2, X5 and X6 are the same or different and represent an arbitrary amino acid residue). (2) X2-Val-Tyr-X5-X6-X7 (where X2, X5, X6 and X7 are the same or different and represent an arbitrary amino acid residue). (3) Ser-X2-X3-(Tyr/Phe/Trp)-X5-X6 (where X2, X3, X5 and X6 are the same or different and represent an arbitrary amino acid residue). (4) X2-X3-(Tyr/Phe/Trp)-X5-X6-Arg (where X2, X3, X5 and X6 are the same or different and represent an arbitrary amino acid residue).
Inventors:
HAMADA YOSHINOSUKE (JP)
MATSUURA NARIAKI (JP)
KAWAGUCHI NAOMASA (JP)
MORI SEIJI (JP)
UCHINAKA AYAKO (JP)
MATSUURA NARIAKI (JP)
KAWAGUCHI NAOMASA (JP)
MORI SEIJI (JP)
UCHINAKA AYAKO (JP)
Application Number:
PCT/JP2015/083380
Publication Date:
June 02, 2016
Filing Date:
November 27, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K38/00; A61K8/64; A61K9/06; A61P9/02; A61P17/02; A61P43/00; A61Q19/08; C07K7/06; C07K14/52
Foreign References:
| JP2014525394A | 2014-09-29 |
Other References:
UCHINAKA A. ET AL.: "Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.", CARDIOVASCULAR RESEARCH, vol. 99, no. 1, 2013, pages 102 - 110, ISSN: 0008-6363
EGHBALI M. ET AL.: "Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors.", CIRCULATION RESEARCH, vol. 69, no. 2, 1991, pages 483 - 490, ISSN: 0009-7330
HAM S.A. ET AL.: "PPARdelta promotes wound healing by up-regulating TGF-betal-dependent or -independent expression of extracellular matrix proteins.", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 14, no. 6B, 2010, pages 1747 - 1759, ISSN: 1582-1838
VARGA J. ET AL.: "Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.", BIOCHEMICAL JOURNAL, vol. 247, no. 3, 1987, pages 597 - 604, ISSN: 0264-6021
HUNTER C. ET AL.: "The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity.", JOURNAL OF SURGICAL RESEARCH, vol. 176, no. 1, 2012, pages 348 - 358, XP055169640, ISSN: 0022-4804, DOI: doi:10.1016/j.jss.2011.07.054
SHARMA A. ET AL.: "Differential regulation of angiogenic genes in diabetic wound healing.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 126, no. 10, 2006, pages 2323 - 2331, ISSN: 0022-202X
HAMADA Y. ET AL.: "Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo.", DENTAL MATERIALS JOURNAL, vol. 23, no. 4, 2004, pages 650 - 655, XP008052345, ISSN: 0287-4547
EGHBALI M. ET AL.: "Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors.", CIRCULATION RESEARCH, vol. 69, no. 2, 1991, pages 483 - 490, ISSN: 0009-7330
HAM S.A. ET AL.: "PPARdelta promotes wound healing by up-regulating TGF-betal-dependent or -independent expression of extracellular matrix proteins.", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 14, no. 6B, 2010, pages 1747 - 1759, ISSN: 1582-1838
VARGA J. ET AL.: "Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.", BIOCHEMICAL JOURNAL, vol. 247, no. 3, 1987, pages 597 - 604, ISSN: 0264-6021
HUNTER C. ET AL.: "The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity.", JOURNAL OF SURGICAL RESEARCH, vol. 176, no. 1, 2012, pages 348 - 358, XP055169640, ISSN: 0022-4804, DOI: doi:10.1016/j.jss.2011.07.054
SHARMA A. ET AL.: "Differential regulation of angiogenic genes in diabetic wound healing.", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 126, no. 10, 2006, pages 2323 - 2331, ISSN: 0022-202X
HAMADA Y. ET AL.: "Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo.", DENTAL MATERIALS JOURNAL, vol. 23, no. 4, 2004, pages 650 - 655, XP008052345, ISSN: 0287-4547
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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