COMBINATION OF BRAF AND VEGF INHIBITORS

Title:

COMBINATION OF BRAF AND VEGF INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2012/036919

Kind Code:

A3

Abstract:

A novel combination comprising the VEGFR inhibitor 5-[[4-[(2,3-dimethyl-2H- indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a B-Raf inhibitor, particularly N-{3-[5- (2-Amino-4-pyrimidinyl)-2-(1,1 -dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6- difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of VEGFR and/or B-Raf is beneficial.

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Inventors:

KUMAR RAKESH (US)

Application Number:

PCT/US2011/050302

Publication Date:

August 16, 2012

Filing Date:

September 02, 2011

Export Citation:

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Assignee:

GLAXOSMITHKLINE LLC (US)
KUMAR RAKESH (US)

International Classes:

A61K31/18; A01N41/06

Foreign References:

US20090298815A1	2009-12-03
US20100010022A1	2010-01-14

Other References: