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Title:
COMBINATION OF DODECANOIC ACID AND PROSTAGLANDIN E2 AS AUXILIARY DIAGNOSTIC MARKER OF MACROSOMIA AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/201216
Kind Code:
A1
Abstract:
Disclosed is a combination of dodecanoic acid and prostaglandin E2 acting as an auxiliary diagnostic marker of macrosomia and an application thereof, relating to the fields of analytical chemistry and clinical medicine, wherein the marker is metabolic small molecular dodecanoic acid and prostaglandin E2 of serum during pregnancy. The marker adopts the UPLC-Q exactive MS method for detection, has better sensitivity and specificity, and is capable of being used for the early diagnosis or monitoring of macrosomia, thereby having a better promotional value in clinical applications.

Inventors:
CHEN MINJIAN (CN)
ZHAO ZIPING (CN)
WEI XIAOQI (CN)
CAO YIZHI (CN)
ZHUANG TINGYU (CN)
HUANG YANQIAN (CN)
DAI LIRUI (CN)
ZHANG YI (CN)
WANG QING (CN)
ZHANG PENGPENG (CN)
ZHANG JING (CN)
PEI YUYANG (CN)
HU YANHUI (CN)
SUN RONGLI (CN)
LU CHUNCHENG (CN)
WU WEI (CN)
XIA YANKAI (CN)
WANG XINRU (CN)
Application Number:
PCT/CN2019/082754
Publication Date:
October 24, 2019
Filing Date:
April 15, 2019
Export Citation:
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Assignee:
UNIV NANJING MEDICAL (CN)
International Classes:
G01N30/02; G01N30/72; G01N33/88; G01N33/96
Domestic Patent References:
WO2016020495A12016-02-11
WO2016020489A12016-02-11
WO2016050758A12016-04-07
Foreign References:
CN108872424A2018-11-23
CN107576747A2018-01-12
CN107576747A2018-01-12
CN106556655A2017-04-05
CN106556655A2017-04-05
CN105181869A2015-12-23
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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