Title:
COMBINATION DRUG
Document Type and Number:
WIPO Patent Application WO/2024/048555
Kind Code:
A1
Abstract:
The present invention relates to a therapeutic or prophylactic drug, a combination, a pharmaceutical composition, a preparation, a therapeutic or prophylactic method, and a growth suppressor for ALK fusion gene-positive cancer having temporary tolerance to ALK inhibitors, all of which act against ALK fusion gene-positive cancer and involve combining an ALK inhibitor and a TNKS inhibitor or further combining with a pan-HER inhibitor.
Inventors:
FUJIMURA TAKAAKI (JP)
FURUGAKI KO (JP)
FURUGAKI KO (JP)
Application Number:
PCT/JP2023/031120
Publication Date:
March 07, 2024
Filing Date:
August 29, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K45/06; A61K31/439; A61K31/4439; A61K31/4545; A61K31/4709; A61K31/496; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61P35/00; A61P43/00
Domestic Patent References:
| WO2020251965A1 | 2020-12-17 |
Other References:
PLUMMER RUTH; DUA DIVYANSHU; CRESTI NICOLA; DREW YVETTE; STEPHENS PETER; FOEGH MARIE; KNUDSEN STEEN; SACHDEV PALLAVI; MISTRY BIPIN: "First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP UK, LONDON, vol. 123, no. 4, 11 June 2020 (2020-06-11), London, pages 525 - 533, XP037222471, ISSN: 0007-0920, DOI: 10.1038/s41416-020-0916-5
WANG YALI, ZHENG KUN, HUANG YONGBIAO, XIONG HUA, SU JINFANG, CHEN RUI, ZOU YANMEI: "PARP inhibitors in gastric cancer: beacon of hope", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 40, no. 1, 1 December 2021 (2021-12-01), London UK , XP093143949, ISSN: 1756-9966, DOI: 10.1186/s13046-021-02005-6
ANN-GERD THORSELL, TORUN EKBLAD, TOBIAS KARLBERG, MIRJAM LöW, ANA FILIPA PINTO, LIONEL TRéSAUGUES, MARTIN MOCHE, MICHAEL: "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 4, 23 February 2017 (2017-02-23), US , pages 1262 - 1271, XP055730220, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00990
ZAMUDIO-MARTINEZ ESTEBAN, HERRERA-CAMPOS ANA BELÉN, MUÑOZ ALBERTO, RODRÍGUEZ-VARGAS JOSÉ MANUEL, OLIVER F. JAVIER: "Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 40, no. 1, 1 December 2021 (2021-12-01), London UK , XP093143951, ISSN: 1756-9966, DOI: 10.1186/s13046-021-01950-6
JÄNNE PASI A., SHAW ALICE T., CAMIDGE D. ROSS, GIACCONE GIUSEPPE, SHREEVE S. MARTIN, TANG YIYUN, GOLDBERG ZELANNA, MARTINI JEAN-FR: "Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non–Small Cell Lung Cancer: Results of a Phase I Study", JOURNAL OF THORACIC ONCOLOGY, vol. 11, no. 5, 1 May 2016 (2016-05-01), pages 737 - 747, XP093143953, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2016.01.022
WANG YALI, ZHENG KUN, HUANG YONGBIAO, XIONG HUA, SU JINFANG, CHEN RUI, ZOU YANMEI: "PARP inhibitors in gastric cancer: beacon of hope", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 40, no. 1, 1 December 2021 (2021-12-01), London UK , XP093143949, ISSN: 1756-9966, DOI: 10.1186/s13046-021-02005-6
ANN-GERD THORSELL, TORUN EKBLAD, TOBIAS KARLBERG, MIRJAM LöW, ANA FILIPA PINTO, LIONEL TRéSAUGUES, MARTIN MOCHE, MICHAEL: "Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 4, 23 February 2017 (2017-02-23), US , pages 1262 - 1271, XP055730220, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b00990
ZAMUDIO-MARTINEZ ESTEBAN, HERRERA-CAMPOS ANA BELÉN, MUÑOZ ALBERTO, RODRÍGUEZ-VARGAS JOSÉ MANUEL, OLIVER F. JAVIER: "Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, BIOMED CENTRAL LTD, LONDON UK, vol. 40, no. 1, 1 December 2021 (2021-12-01), London UK , XP093143951, ISSN: 1756-9966, DOI: 10.1186/s13046-021-01950-6
JÄNNE PASI A., SHAW ALICE T., CAMIDGE D. ROSS, GIACCONE GIUSEPPE, SHREEVE S. MARTIN, TANG YIYUN, GOLDBERG ZELANNA, MARTINI JEAN-FR: "Combined Pan-HER and ALK/ROS1/MET Inhibition with Dacomitinib and Crizotinib in Advanced Non–Small Cell Lung Cancer: Results of a Phase I Study", JOURNAL OF THORACIC ONCOLOGY, vol. 11, no. 5, 1 May 2016 (2016-05-01), pages 737 - 747, XP093143953, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2016.01.022
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Download PDF: