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Title:
A COMBINATION OF FIG (FICUS CARICA) FRUIT EXTRACT AND OLIVE (OLEA EUROPAEA) LEAF EXTRACT
Document Type and Number:
WIPO Patent Application WO/2013/162484
Kind Code:
A1
Abstract:
The present invention is related to a pharmaceutical product produced from the defined sections of figs (Ficus carica) and olives (Olea europaea), in order to be used as a supplement and supportive in eliminating formed cancer cells and in preventing the formation of cancer cells, and the formulation of said product.

Inventors:
ERASLAN, Mustafa (Strazburg Caddesi 38/8 Sıhhiye, Ankara, 06410, TR)
TEKIN, Mustafa (Serçeönü Mh. Çankaya Cd. 3/8, Kocasinan Kayseri, 38010, TR)
Application Number:
TR2012/000157
Publication Date:
October 31, 2013
Filing Date:
September 28, 2012
Export Citation:
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Assignee:
ERASLAN, Mustafa (Strazburg Caddesi 38/8 Sıhhiye, Ankara, 06410, TR)
TEKIN, Mustafa (Serçeönü Mh. Çankaya Cd. 3/8, Kocasinan Kayseri, 38010, TR)
International Classes:
A61K36/60; A61K36/63; A61P3/00; A61P9/00; A61P35/00; A61P37/04
Domestic Patent References:
WO1988004536A11988-06-30
WO2008040790A12008-04-10
Foreign References:
US4534364A1985-08-13
Other References:
DATABASE WPI Week 200845, Derwent World Patents Index; AN 2008-H03822, XP002695581
DATABASE WPI Week 201225, Derwent World Patents Index; AN 2012-B46934, XP002695582
DATABASE WPI Week 200936, Derwent World Patents Index; AN 2009-J39945, XP002695583
EDDOUKS M ET AL: "The use of medicinal plants in the treatment of diabetes in Morocco", PHYTOTHÉRAPIE, SPRINGER-VERLAG, PARIS, FR, vol. 5, no. 4, 1 October 2007 (2007-10-01), pages 194 - 203, XP009165470, ISSN: 1624-8597
RIDA FARES ET AL.: "The Antioxidant and Anti-proliferative Activity of the Lebanese Olea europaea Extract", PLANT FOODS FOR HUMAN NUTRITION (DORDRECHT), vol. 66, no. 1, March 2011 (2011-03-01), pages 58 - 63, XP009168866, DOI: 10.1007/S11130-011-0213-9
MARRELLI M ET AL: "Changes in the phenolic and lipophilic composition, in the enzyme inhibition and antiproliferative activity of Ficus carica L. cultivar Dottato fruits during maturation", FOOD AND CHEMICAL TOXICOLOGY 2012 ELSEVIER LTD GBR, vol. 50, no. 3-4, March 2012 (2012-03-01), pages 726 - 733, XP009168865, ISSN: 0278-6915
Attorney, Agent or Firm:
YALCINER, Ugur, G. (YALCINER PATENT VE DANISMANLIK LTD. STI.) (Tunus Caddesi No:85/3-4, Kavaklidere, Çankaya / Ankara, 06680, TR)
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Claims:
CLAIMS

1. An herbal pharmaceutical combination prepared with a mixture of extracts obtained from the defined sections of figs (Ficus carica) and olives (Olea europaea).

2. An herbal pharmaceutical combination according to Claim 1, wherein the fruit extract of figs are used.

3. An herbal pharmaceutical combination wherein the leaf extract of the olives mentioned in Claim 1 are used.

4. An herbal pharmaceutical combination according to Claim 1, 2 and 3, wherein the olive leaf extract rate is 1 to 5 units against the 1 unit of fig fruit extract.

5. An herbal pharmaceutical combination according to Claim 4, wherein the combination comprises preferably 3 units of olive leaf extract against the 1 unit of fig fruit extract.

6. An herbal pharmaceutical combination according to claims 1, 2, 3, 4 and 5 wherein said mixture indicated to be used as a supportive or supplemental product in preventing the formation of cancerous cells, eliminating formed cancer cells, strengthening the immune system, regulating blood pressure and blood sugar.

Description:
DESCRIPTION

A COMBINATION OF FIG {Ficus carica) FRUIT EXTRACT AND OLIVE {Olea europaea) LEAF EXTRACT The present invention is related to a pharmaceutical product produced from the defined sections of figs {Ficus carica) and olives {Olea europaea), in order to be used as a supplement and supportive in eliminating formed cancer cells and in preventing the formation of cancer cells, and the formulation of said product. Ficus carica (fig) from the Moracae family inside the combination developed, has many wild and cultural sub types. The nutritional value of this fruit is high. Inside its compound, invert sugar (Sacarose mixtures such as Fructose, Glycose etc), pectine, fixed oils and protein is present. It contains vitamins B,C, and D and Provitamin A (β- Carotene), iron, potassium, phosphor, sulphur, magnesium, calcium and sodium. Fig, prevents the spreading and growth of cancerous cells via the anthocyanydol, flavanoid and polysaccharites it contains. Figs strengthen the immune system of the body against cancer, gives energy to the body and helps in eliminating exhaustion and fatigue. It repairs and renews cells with the protein it contains. It also boosts blood with its rich iron mineral content. Some benefits of figs are that they contain high amount of fibre, thus relieving your bowels, they speed up your digestive system, they are good in treating constipation and have a laxative effect. Figs can also be used in treating hemorroids. Figs have a protective effect against many cancer types. As it is beneficial in treating especially discomforts in the digestive system it is indicated that figs can prevent colon cancer.

One of the benefits of figs is that they have an effect to lower cholesterol by balancing the fat rates in blood. By balancing the fat rate cardiovascular diseases are also prevented. When cholesterol increase is prevented, the accumulation of cholesterol in kidneys is also prevented thus ensuring that kidney failure diseases are eliminated. Another benefit of figs is that it also balances blood sugar. Figs contain a high amount of fibres which help in weight loss. Olive tree leaves within the developed combination are acquired from olive (Olea europaea) trees which is a tree specific to the Meditteranean climate whose fruit originates from the olive (Oleaceae) family.

Olives contain a high amount of vegetal protein, oils, A, C, E vitamins, and minerals such as calcium, phosphor, sulphur, chlorine, and magnesium. Olives are very beneficial for obtaining cardiovascular health and they also decrease the effects of aging. It is known by the American Canser Research Institute that olive leaves are the 21 'st Century's most effective natural antimicrobial and antiviral plants. There are 69 books, more than 800 articles, journals and various other publications regarding this issue. Besides the effects of olive leaves in relation to the balancing of the blood sugar levels and its effects as an antimicrobial, antiviral and antioxidant agent it is also known that olive leaves effect the coronary veins and helps to increase LDL cholesterol levels. Olive leaves are also effective in curing other diseases and microorganisms such as bronchitis, common cold, ear infections, Epstein bar virus, fibromalaria, fungal infections, herpes virus, Chlamydia sp., dysentery, streptococcus sp., hepatitis A, B, C, pneumonia, skin diseased, shingles and rheumatismal diseases.

Oleuropein is a phytochemical that can be found in abundance in olive trees. Oleuropein and hydroxytyrosol which is a degradation product, are both very effective antioxidants. Oleuropein are known to have pharmacological effects that can strengthen the immune system, and balance blood pressur and blood sugar. Oleuropein, is found in the barks of olive trees, its trunk, fruits, oil and mostly in the leaves of olive trees (40 times more in comparison to the amount found in olive oil). Oleuropein is the primary molecule that shows antioxidant characteristics in olive tree leaves. In the laboratory studies carried out, it has been observed that oleuropein prevented (antioxidant effect) the oxidization of LDL cholesterol. The extracts (essence) of olive tree leaves are very beneficial to the health and do not have any toxic characteristics. Dry olive tree leave extracts which comprises 6-15% of oleuropein are being commercially traded.

The natural antioxidants inside the olive tree leaves are as follows: Phenolic compounds such as oleuropein, hrydoxytyrosol, verbascosyte, Apigenin-7-glucosate, Luteolin-7-glucosate, Tyrosole, Vanillic acid, Diosmetin-7-glucosate, Cafeic acid, Luteolin, Rutin, Diosmetin, Vanillin, catechin.

In the Chinese patent application numbered CN101375700 a production method of the dried fruit of Ficus carica in order to increase the strength of the immune system against cancer is described. In the Chinese patent application numbered CN101375695 a production method of the dried fruit of Ficus carica to be used against cancer and cardiovascular diseases is described.

In the Chinese patent application numbered CN 1814153 describes a formulation of Ficus Carica, mixed with herbal products such as Radix Astragali, Chinese Angelica, Radix Asparagi, Fructus Aurantii Immaturus used in preventing breast cancer.

In the German patent application numbered DEI 02009038565 the usage of olive tree leave extracts, together with some extracts such as, apple juice extracts, wine and kiwi seed extracts to provide cytostatic, anti- inflammatory and immunostimulant effects is described.

In the Chinese patent application numbered CN101095447 the usage of Ficus carica, prepared with a combination of olives, mushrooms, onions, honeysuckle flowers as a coffee in order to treat in getting rid of toxins and to be used in beauty treatment is described. The effects such as strengthening the immune system, and antioxidant effects of both ficus carica fruit (fig) extract and olive leaf extracts which are included in the present combination have been known for many years.

With the present combination which has been developed the effects such as strengthening the immune system and antioxidant effects of figs and olive leaves have been improved. The present invention has ensured that instead of using both products separately, the extracts of the two ingredients were combined thus providing an increase in bio-availability.

If olive leaves, and figs or extracts thereof were to be taken separately, most of the active agents inside these could be excreted out of the body being met by intestinal bacteria before being absorbed or before breaking down in the stomach and changing into compounds that the body could benefit from.

In the combination developed according to the present invention, as a result of using the fig fruit extract and the olive leaf extract together a synergy is achieved and the necessary theraupetic dose is acquired. Preparation method (Cyrup):

Sweeteners and preservatives are added inside a sufficient amount of water and the water is heated and then cooled. As a sweetener all kinds of sweeteners and artificial sweeteners can be used. On top of this fig fruit extract and olive leaf extract is added and mixed. Propylenglycole and glycerol is added to the mixture as a stabilizer and the mixture is mixed further. Citric acid is prepared between pH 5-6. All kinds of tampon material that can balance Ph instead of citric acid can be used and pure water is added to achieve the complete volume that is desired. The mixture is mixed for a while, then poured into 100 or 200ml glass bottles.

Preparation method (solid gelatine capsule):

In this combination taken orally developed for solid and liquid forms, the solid fig fruit extract and the solid olive leaf extracts are taken in different proportions, magnesium stearate is added and the mixture is mixed until a homogenous mixture is obtained. Other lubricants can be used instead of magnesium stearate.

The homogenous mixture is filled into gelatine capsules. The combination can be produced in all kinds of hard, liquid and semi liquid dosage forms, presented as soft gelatine capsules, as tablets, pellets, sachets and cyrup.

The olive leaf extract amount and the fig fruit extract amounts added into the mixture can vary according to the amouns of active ingredients they comprise. For this reason each extract amount may be different inside a combination. Against 1 unit of fig fruit extract within the combination 1 to 5 units of oleuropein carrying extract of the olive leave could be present. Liquid extracts can be used within the combination and so can solid extracts.

The extract combination developed according to the present invention can be used as a supportive or supplemental product in preventing the formation of cancerous cells, eliminating formed cancer cells, strengthening the immune system, regulating blood pressure and blood sugar.