Title:
COMBINATION OF HEPATITIS B VACCINE WITH ANTIVIRAL AGENTS
Document Type and Number:
WIPO Patent Application WO2000041463
Kind Code:
A3
Abstract:
This invention provides a pharmaceutical pack comprising as active ingredients (1) an antiviral agent active against hepatitis B virus and (2) a vaccine for the prophylaxis and/or treatment of hepatitis B infection, the active ingredients being for simultaneous or sequential use. Preferred components are a nucleoside analogue as the antiviral agent, together with a hepatitis B virus vaccine which comprises a hepatitis B virus surface antigen.
Inventors:
ATKINSON GILLIAN FRANCES (GB)
BOON RONALD JAMES (GB)
VANDEPAPELIERE PIERRE G (BE)
WETTENDORFF MARTINE ANNE CECIL (BE)
BOON RONALD JAMES (GB)
VANDEPAPELIERE PIERRE G (BE)
WETTENDORFF MARTINE ANNE CECIL (BE)
Application Number:
PCT/EP1999/010295
Publication Date:
November 09, 2000
Filing Date:
December 21, 1999
Export Citation:
Assignee:
SMITHKLINE BEECHAM BIOLOG (BE)
ATKINSON GILLIAN FRANCES (GB)
BOON RONALD JAMES (GB)
VANDEPAPELIERE PIERRE G (BE)
WETTENDORFF MARTINE ANNE CECIL (BE)
ATKINSON GILLIAN FRANCES (GB)
BOON RONALD JAMES (GB)
VANDEPAPELIERE PIERRE G (BE)
WETTENDORFF MARTINE ANNE CECIL (BE)
International Classes:
A61K31/513; A61K31/522; A61K31/662; A61K31/7052; A61K31/7056; A61K45/00; A61K31/7076; A61K38/21; A61K39/00; A61K39/29; A61K39/39; A61P1/16; A61P31/20; (IPC1-7): A61K39/29; A61K31/52; A61K31/70; A61K38/21; A61P5/00
Domestic Patent References:
| WO1999045957A2 | 1999-09-16 |
Foreign References:
| EP0414374A2 | 1991-02-27 |
Other References:
BONI C ET AL: "Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B [see comments].", JOURNAL OF CLINICAL INVESTIGATION, (1998 SEP 1) 102 (5) 968-75., XP000909082
BERENGUER M ET AL: "Hepatitis B and C viruses: Molecular identification and targeted antiviral therapies", PROCEEDINGS ASSOCIATION OF AMERICAN PHYSICIANS, vol. 110, no. 2, March 1998 (1998-03-01), pages 98 - 112, XP000909240
PIANKO S. ET AL: "Chronic hepatitis B: New therapies on the horizon?.", LANCET, (13 NOV 1999) 354/9191 (1662-1663)., XP000906960
GROB P J: "Hepatitis B: virus, pathogenesis and treatment", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 16, no. 1001, November 1998 (1998-11-01), pages S11 - S16, XP004150417, ISSN: 0264-410X
VALDEZ H ET AL: "Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials Group.", AIDS, (2000 JAN 7) 14 (1) 11-21., XP000909260
RUDD, JENNIFER N. (1) ET AL: "Possible role for hepatitis B vaccine after lamivudine rescue for severe acute hepatitis B.", GASTROENTEROLOGY, (APRIL, 1999) VOL. 116, NO. 4 PART 2, PP. A1268. MEETING INFO.: DIGESTIVE DISEASE WEEK AND THE 100TH ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION ORLANDO, FLORIDA, USA MAY 16-19, 1999 AMERICAN GASTROENTEROLOGICAL A, XP000909262
SUK-FONG LOK A.: "Hepatitis B infection: Pathogenesis and management.", JOURNAL OF HEPATOLOGY, SUPPLEMENT, (2000) 32/1 (89-97)., XP000909278
MOLLOY P J ET AL: "Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa.", HEPATO-GASTROENTEROLOGY, (1999 JUL-AUG) 46 (28) 2529-31., XP000909277
BERENGUER M ET AL: "Hepatitis B and C viruses: Molecular identification and targeted antiviral therapies", PROCEEDINGS ASSOCIATION OF AMERICAN PHYSICIANS, vol. 110, no. 2, March 1998 (1998-03-01), pages 98 - 112, XP000909240
PIANKO S. ET AL: "Chronic hepatitis B: New therapies on the horizon?.", LANCET, (13 NOV 1999) 354/9191 (1662-1663)., XP000906960
GROB P J: "Hepatitis B: virus, pathogenesis and treatment", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 16, no. 1001, November 1998 (1998-11-01), pages S11 - S16, XP004150417, ISSN: 0264-410X
VALDEZ H ET AL: "Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials Group.", AIDS, (2000 JAN 7) 14 (1) 11-21., XP000909260
RUDD, JENNIFER N. (1) ET AL: "Possible role for hepatitis B vaccine after lamivudine rescue for severe acute hepatitis B.", GASTROENTEROLOGY, (APRIL, 1999) VOL. 116, NO. 4 PART 2, PP. A1268. MEETING INFO.: DIGESTIVE DISEASE WEEK AND THE 100TH ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION ORLANDO, FLORIDA, USA MAY 16-19, 1999 AMERICAN GASTROENTEROLOGICAL A, XP000909262
SUK-FONG LOK A.: "Hepatitis B infection: Pathogenesis and management.", JOURNAL OF HEPATOLOGY, SUPPLEMENT, (2000) 32/1 (89-97)., XP000909278
MOLLOY P J ET AL: "Combined interferon, famciclovir and GM-CSF treatment of HBV infection in an individual with periarteritis nodosa.", HEPATO-GASTROENTEROLOGY, (1999 JUL-AUG) 46 (28) 2529-31., XP000909277
Download PDF: