Title:
COMBINATION OF LIPOIC ACID AND C1 DONORS FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO2001085165
Kind Code:
A3
Abstract:
The invention relates to the use of lipoic acid and C1 donors, especially S-adenosylmethionine and/or 5-methyltetrahydrofolate, for treating disorders of the central nervous system. The invention also relates to agents containing a corresponding active substance combination and to agents in the form of commercial packages containing the inventive combination preparations or monopreparations for combined use.
Inventors:
HAEHNLEIN WOLFGANG (DE)
KRAEMER KLAUS (DE)
HASSELWANDER OLIVER (DE)
MUELLER WALTER E (DE)
ECKERT GUENTHER P (DE)
KRAEMER KLAUS (DE)
HASSELWANDER OLIVER (DE)
MUELLER WALTER E (DE)
ECKERT GUENTHER P (DE)
Application Number:
PCT/EP2001/005359
Publication Date:
May 02, 2002
Filing Date:
May 10, 2001
Export Citation:
Assignee:
BASF AG (DE)
HAEHNLEIN WOLFGANG (DE)
KRAEMER KLAUS (DE)
HASSELWANDER OLIVER (DE)
MUELLER WALTER E (DE)
ECKERT GUENTHER P (DE)
HAEHNLEIN WOLFGANG (DE)
KRAEMER KLAUS (DE)
HASSELWANDER OLIVER (DE)
MUELLER WALTER E (DE)
ECKERT GUENTHER P (DE)
International Classes:
A61K31/385; A61K31/519; A61K31/7076; A61K45/00; A61P25/00; A61P25/24; A61P25/28; C07D475/04; C07D339/04; C07H19/16; (IPC1-7): A61K31/385; A61K31/7076; A61K31/519; A61P25/00
Foreign References:
| FR4630M | ||||
| US5292538A | 1994-03-08 | |||
| DE4343592A1 | 1995-06-22 | |||
| US4057686A | 1977-11-08 | |||
| EP0388827A1 | 1990-09-26 |
Other References:
STOLL, S. (1) ET AL: "The potent free radical scavenger alpha - lipoic acid improves cognition in rodents.", ZS.-NAGY, I. [EDITOR];HARMAN, D. [EDITOR]; KITANI, K. [EDITOR]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, (1994) VOL. 717, PP. 122-128. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; PHARMACOLOGY OF AGING PROCESSES: METHODS OF ASSESSMENT AND POTENTIAL, XP001029748
PASSERI M ET AL: "ORAL 5 METHYLTETRAHYDROFOLATE MTHF IN DEPRESSION ASSOCIATED WITH SENILE ORGANIC MENTAL DISORDERS OMDS A DOUBLE-BLIND MULTICENTER STUDY VS TRAZODONE TRZ.", 25TH MEETING OF THE EUROPEAN SOCIETY FOR CLINICAL INVESTIGATION, PISA, ITALY, APRIL 3-6, 1991. EUR J CLIN INVEST. (1991) 21 (2 PART 2), 24., XP001029044
PASSERI M ET AL: "ORAL 5 METHYLTETRAHYDROFOLATE MTHF IN DEPRESSION ASSOCIATED WITH SENILE ORGANIC MENTAL DISORDERS OMDS A DOUBLE-BLIND MULTICENTER STUDY VS TRAZODONE TRZ.", 25TH MEETING OF THE EUROPEAN SOCIETY FOR CLINICAL INVESTIGATION, PISA, ITALY, APRIL 3-6, 1991. EUR J CLIN INVEST. (1991) 21 (2 PART 2), 24., XP001029044
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