Title:
COMBINATION THERAPIES TARGETING TUMOR-ASSOCIATED STROMA OR TUMOR CELLS AND TOPOISOMERASE
Document Type and Number:
WIPO Patent Application WO/2015/191583
Kind Code:
A3
Abstract:
The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a topoisomerase inhibitor; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
Inventors:
SAHA SAURABH (US)
ZHANG XIAOYAN M (US)
DIMITROV DIMITER (US)
ZHU ZHONGYU (US)
ST CROIX BRAD (US)
ZUDAIRE ENRIQUE (US)
ZHANG XIAOYAN M (US)
DIMITROV DIMITER (US)
ZHU ZHONGYU (US)
ST CROIX BRAD (US)
ZUDAIRE ENRIQUE (US)
Application Number:
PCT/US2015/034908
Publication Date:
February 18, 2016
Filing Date:
June 09, 2015
Export Citation:
Assignee:
BIOMED VALLEY DISCOVERIES INC (US)
US HEALTH (US)
US HEALTH (US)
International Classes:
A61K39/395; A61P35/00; C07K16/28; C07K16/30
Domestic Patent References:
| WO2011053763A2 | 2011-05-05 | |||
| WO2015054691A2 | 2015-04-16 |
Foreign References:
| US20140134179A1 | 2014-05-15 | |||
| US8519107B2 | 2013-08-27 | |||
| US8394378B2 | 2013-03-12 | |||
| US20030059937A1 | 2003-03-27 | |||
| AU2009200977A1 | 2009-04-02 | |||
| US20030166163A1 | 2003-09-04 |
Attorney, Agent or Firm:
HOOPER, Kevin (1290 Avenue of the AmericasNew York, New York, US)
Download PDF: