Title:
COMBINATION THERAPIES AND USES FOR TREATMENT OF DEMYELINATING DISORDERS
Document Type and Number:
WIPO Patent Application WO/2014/058875
Kind Code:
A3
Abstract:
Methods and compositions for enhancing one or more of: myelination, re-myelination, oligodendrocyte numbers, or neuroaxonal protection, while ameliorating an inflammatory condition in a human subject are disclosed. In certain embodiments, the methods and compositions described herein include a reparative agent (e.g., a LINGO-1 antagonist) and an immunomodulatory agent, in combination. Thus, methods, compositions and kits described herein can be useful for treating a CNS demyelinating disease.
Inventors:
CADAVID DIEGO (US)
MI SHA (US)
MI SHA (US)
Application Number:
PCT/US2013/063873
Publication Date:
June 12, 2014
Filing Date:
October 08, 2013
Export Citation:
Assignee:
BIOGEN IDEC INC (US)
International Classes:
A61K39/395; A61K39/00; A61P25/28; C07K16/28
Other References:
S HAUSER ET AL: "The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration", NEURON, vol. 52, no. 1, 5 October 2006 (2006-10-05), pages 61 - 76, XP055098078, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2006.09.011
MI SHA ET AL: "LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 13, no. 10, 30 September 2007 (2007-09-30), pages 1228 - 1233, XP002525677, ISSN: 1078-8956, [retrieved on 20070930], DOI: 10.1038/NM1664
SHA MI ET AL: "Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells", ANNALS OF NEUROLOGY, vol. 65, no. 3, 1 March 2009 (2009-03-01), pages 304 - 315, XP055098017, ISSN: 0364-5134, DOI: 10.1002/ana.21581
MI SHA ET AL: "LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 13, no. 10, 30 September 2007 (2007-09-30), pages 1228 - 1233, XP002525677, ISSN: 1078-8956, [retrieved on 20070930], DOI: 10.1038/NM1664
SHA MI ET AL: "Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells", ANNALS OF NEUROLOGY, vol. 65, no. 3, 1 March 2009 (2009-03-01), pages 304 - 315, XP055098017, ISSN: 0364-5134, DOI: 10.1002/ana.21581
Attorney, Agent or Firm:
COLLAZO, Diana, M. (Riverfront Office ParkOne Main Street, Suite 110, Cambridge MA, US)
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