Title:
COMBINATION THERAPY OF SUBSTANCE-P FOR MOBILIZATION OF HEMATOPOIETIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2022/014985
Kind Code:
A1
Abstract:
The present invention relates to: a combination therapy and a combination product that are for the mobilization of a large amount of hematopoietic stem cells in blood and include substance-P and AMD3100 or a pharmaceutically acceptable salt thereof; a method for collecting a large amount of mobilized hematopoietic stem cells, the method comprising a step for isolating a blood fraction containing the mobilized hematopoietic stem cells from peripheral blood obtained from an individual sequentially administered with substance P and AMD3100 or a pharmaceutically acceptable salt thereof; and a use of a combined product containing substance P and AMD3100 or a pharmaceutically acceptable salt thereof for the mobilization of a large amount of hematopoietic stem cells in blood.
Inventors:
SON YOUNG SOOK (KR)
HONG HYUN SOOK (KR)
PARK JEONG SEOP (KR)
HONG HYUN SOOK (KR)
PARK JEONG SEOP (KR)
Application Number:
PCT/KR2021/008882
Publication Date:
January 20, 2022
Filing Date:
July 12, 2021
Export Citation:
Assignee:
ELPHIS CELL THERAPEUTICS (KR)
International Classes:
A61K38/04; A61K31/395; A61M1/02; A61M1/34; A61P43/00; C12N5/0789
Foreign References:
| US20160120947A1 | 2016-05-05 | |||
| US20060127373A1 | 2006-06-15 | |||
| US20190060366A1 | 2019-02-28 | |||
| KR101382484B1 | 2014-04-10 | |||
| KR20170105514A | 2017-09-19 | |||
| KR100593397B1 | 2006-06-28 | |||
| US5612478A | 1997-03-18 |
Other References:
M P RETTIG, G ANSSTAS, J F DIPERSIO: "Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4", LEUKEMIA, NATURE PUBLISHING GROUP UK, LONDON, vol. 26, no. 1, 1 January 2012 (2012-01-01), London, pages 34 - 53, XP055215851, ISSN: 0887-6924, DOI: 10.1038/leu.2011.197
SHUN HE ET AL.: "FLT3L and Plerixafor Combination Increases Hematopoietic Stem Cell Mobilization and Leads to Improved Transplantation Outcome", BIOL BLOOD MARROW TRANSPLANT, vol. 20, no. 3, 2014, pages 309 - 313, XP028623490, DOI: 10.1016/j.bbmt.2013.11.024
MP RETTIG ET AL.: "Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4", LEUKEMIA, vol. 26, 2012, pages 34 - 53, XP055215851, DOI: 10.1038/leu.2011.197
BONE MARROW: "BioMed Research International", 2013, HINDAWI PUBLISHING CORPORATION, pages: 5
SHUN HE ET AL.: "FLT3L and Plerixafor Combination Increases Hematopoietic Stem Cell Mobilization and Leads to Improved Transplantation Outcome", BIOL BLOOD MARROW TRANSPLANT, vol. 20, no. 3, 2014, pages 309 - 313, XP028623490, DOI: 10.1016/j.bbmt.2013.11.024
MP RETTIG ET AL.: "Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4", LEUKEMIA, vol. 26, 2012, pages 34 - 53, XP055215851, DOI: 10.1038/leu.2011.197
BONE MARROW: "BioMed Research International", 2013, HINDAWI PUBLISHING CORPORATION, pages: 5
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
Download PDF: