Title:
COMBINATION THERAPY FOR TREATING CANCER WITH A RECOMBINANT POXVIRUS EXPRESSING A TUMOR ANTIGEN AND AN IMMUNE CHECKPOINT MOLECULE ANTAGONIST OR AGONIST
Document Type and Number:
WIPO Patent Application WO/2015/175334
Kind Code:
A3
Abstract:
The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination with antagonists or agonists of immune checkpoint inhibitors.
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Inventors:
FOY SUSAN (US)
MANDL STEFANIE (US)
ROUNTREE RYAN (US)
FRANZUSOFF ALEX (US)
MANDL STEFANIE (US)
ROUNTREE RYAN (US)
FRANZUSOFF ALEX (US)
Application Number:
PCT/US2015/029855
Publication Date:
February 04, 2016
Filing Date:
May 08, 2015
Export Citation:
Assignee:
BAVARIAN NORDIC INC (US)
International Classes:
A61K39/00; A61K39/39
Domestic Patent References:
| WO2006121168A1 | 2006-11-16 |
Other References:
ESPENSCHIED JONATHAN ET AL: "CTLA-4 blockade enhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model.", JOURNAL OF IMMUNOLOGY, vol. 170, no. 6, 15 March 2003 (2003-03-15), pages 3401 - 3407, XP002443898, ISSN: 0022-1767
MADAN RAVI A ET AL: "Combination of vaccine and immune checkpoint inhibitor is safe with encouraging clinical activity", ONCOIMMUNOLOGY, vol. 1, no. 7, October 2012 (2012-10-01), pages 1167 - 1168, XP002735512, ISSN: 2162-4011
GAMEIRO S R ET AL: "Cancer vaccines targeting carcinoembryonic antigen: State-of-the-art and future promise", EXPERT REVIEW OF VACCINES 2013 EXPERT REVIEWS LTD. GBR, vol. 12, no. 6, June 2013 (2013-06-01), pages 617 - 629, XP008177293, ISSN: 1476-0584
MADAN RAVI A ET AL: "Combination of vaccine and immune checkpoint inhibitor is safe with encouraging clinical activity", ONCOIMMUNOLOGY, vol. 1, no. 7, October 2012 (2012-10-01), pages 1167 - 1168, XP002735512, ISSN: 2162-4011
GAMEIRO S R ET AL: "Cancer vaccines targeting carcinoembryonic antigen: State-of-the-art and future promise", EXPERT REVIEW OF VACCINES 2013 EXPERT REVIEWS LTD. GBR, vol. 12, no. 6, June 2013 (2013-06-01), pages 617 - 629, XP008177293, ISSN: 1476-0584
Attorney, Agent or Firm:
NORTH, Todd (Inc.2425 Garcia Avenu, Mountain View CA, US)
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