Title:
COMBINATION THERAPY FOR THE TREATMENT OF TNBC WITH A PI3K PATHWAY INHIBITOR THAT TARGETS PI3KDELTA AND PI3KGAMMA TNBC
Document Type and Number:
WIPO Patent Application WO/2021/231762
Kind Code:
A3
Abstract:
Methods of treating patients diagnosed with or suspected of having triple negative breast cancer with a combination of compounds that target PI3K isoforms and target PTK7.
Inventors:
RADOVICH MILAN (US)
SOLZAK JEFFREY P (US)
SOLZAK JEFFREY P (US)
Application Number:
PCT/US2021/032298
Publication Date:
December 16, 2021
Filing Date:
May 13, 2021
Export Citation:
Assignee:
UNIV INDIANA TRUSTEES (US)
International Classes:
A61K31/277; A61K47/68; A61K31/381; A61K31/427; A61K31/7105; A61K31/713; A61P35/00
Foreign References:
| US20180094075A1 | 2018-04-05 | |||
| US20180043011A1 | 2018-02-15 |
Other References:
PASCUAL J., TURNER N.C.: "Targeting the PI3-kinase pathway in triple-negative breast cancer", ANNALS OF ONCOLOGY, KLUWER DORDRECHT, NL, vol. 30, no. 7, 1 July 2019 (2019-07-01), NL , pages 1051 - 1060, XP055883913, ISSN: 0923-7534, DOI: 10.1093/annonc/mdz133
JOSE A TAPIA, LUIS J GARCÍA-MARIN, ROBERT T JENSEN: "Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 37, 12 September 2003 (2003-09-12), pages 35220 - 35230, XP055883916
JOSE A TAPIA, LUIS J GARCÍA-MARIN, ROBERT T JENSEN: "Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 37, 12 September 2003 (2003-09-12), pages 35220 - 35230, XP055883916
Attorney, Agent or Firm:
PILCHER, Jessamine G. et al. (US)
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