Title:
COMBINED FORMULATION OF LEUKOTRIENE ANTAGONIST AND EPINASTINE
Document Type and Number:
WIPO Patent Application WO/2013/058527
Kind Code:
A2
Abstract:
The present invention relates to a combined formulation of a leukotriene antagonist and epinastine containing a leukotriene antagonist and epinastine as active ingredients, comprising a pharmaceutical unit, wherein any one of the two active ingredients have an environment separated from that of the other, and a preparation method thereof. The combined formulation has an excellent dissolution rate and bioavailability of a leukotriene antagonist. Furthermore, the two active ingredients synergically reduce eosinophils or inhibit airway hyperresponsiveness, and thus the combined formulation can be very useful for preventing or treating bronchial asthma.
Inventors:
LEE CHANG-KYOO (KR)
PARK SANG-GEUN (KR)
CHOI HYUN-JU (KR)
PARK SANG-GEUN (KR)
CHOI HYUN-JU (KR)
Application Number:
PCT/KR2012/008458
Publication Date:
April 25, 2013
Filing Date:
October 17, 2012
Export Citation:
Assignee:
NAVIPHARM CO LTD (KR)
LEE CHANG-KYOO (KR)
PARK SANG-GEUN (KR)
CHOI HYUN-JU (KR)
LEE CHANG-KYOO (KR)
PARK SANG-GEUN (KR)
CHOI HYUN-JU (KR)
International Classes:
A61K31/47; A61K31/41; A61K31/445; A61K31/55
Foreign References:
| KR100737710B1 | 2007-07-11 | |||
| KR20090103810A | 2009-10-01 | |||
| US20110189274A1 | 2011-08-04 | |||
| KR20080016621A | 2008-02-21 |
Other References:
ALISE REICIN ET AL.: 'Montelukast, a Leukotriene Receptor Antagonist, in Combination With Loratadine, a Histamine Receptor Antagonist, in the Treatment of Chronic Asthma' ARCHIVES INTERNAL MEDICINE vol. 160, 2000, pages 2481 - 2488
Attorney, Agent or Firm:
AJU Kim Chang&Lee (KR)
특허법인 아주양헌 (KR)
특허법인 아주양헌 (KR)
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Claims: