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Title:
COMBINED MEDICINE OF PYRAZOLE DERIVATIVE AND BIGUANIDE DRUG
Document Type and Number:
WIPO Patent Application WO/2011/002001
Kind Code:
A1
Abstract:
Disclosed is a novel medicinal agent useful for the treatment of hyperglycemia-related diseases or the like. Specifically disclosed is a medicinal agent useful for the treatment of hyperglycemia-related diseases or the like, which comprises a combination of 3-(3-{4-[3-(β-D- glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3- methylphenoxy}propylamino)-2,2-dimethylpropionamide, which has an inhibitory activity on SGLT1 (sodium-dependent glucose cotransporter 1), or a pharmacologically acceptable salt thereof and a biguanide drug such as metformin.

Inventors:
INOUE TOSHIHIRO (JP)
FUJIMORI YOSHIKAZU (JP)
TOMAE MASAKI (JP)
Application Number:
PCT/JP2010/061111
Publication Date:
January 06, 2011
Filing Date:
June 30, 2010
Export Citation:
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Assignee:
KISSEI PHARMACEUTICAL (JP)
INOUE TOSHIHIRO (JP)
FUJIMORI YOSHIKAZU (JP)
TOMAE MASAKI (JP)
International Classes:
A61K31/7056; A61K31/155; A61P3/06; A61P3/10; A61P5/50; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P19/06; A61P43/00
Domestic Patent References:
WO2004018491A12004-03-04
WO2009084531A12009-07-09
Other References:
LENZEN, S. ET AL.: "Effect of metformin on SGLT1, GLUT2, and GLUT5 hexose transporter gene expression in small intestine from rats", BIOCHEM PHARMACOL, vol. 51, no. 7, 1996, pages 893 - 896
SAKAR, Y. ET AL.: "Mechanisms of Metformin- induced inhibition of intestinal D-glucose absorption", GASTROENTEROLOGY, vol. 134, no. 4, April 2008 (2008-04-01), pages A582, XP023434518, DOI: doi:10.1016/S0016-5085(08)62721-3
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