Title:
COMBRETASTATIN A4 DERIVATIVE AND PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/063559
Kind Code:
A1
Abstract:
The present invention belongs to the field of medical technology, and in particular relates to a preparation of a combretastatin A4 derivative, said derivative being obtained by reacting the combretastatin A4 with stearyl chloride in the presence of substitution reaction conditions and an acid-binding agent, and the structural formula whereof is shown as (I). Also provided in the present invention is a nano-preparation of the derivative. The preparation has many advantages, such as improving the anti-tumor effect of the medicine, increasing the stability of the medicine and reducing the toxicity and side effects of the medicine, etc.
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Inventors:
ZHOU QINQIN (CN)
SHAN BIN (CN)
SHAN BIN (CN)
Application Number:
PCT/CN2016/101907
Publication Date:
April 20, 2017
Filing Date:
October 12, 2016
Export Citation:
Assignee:
SHANGHAI TIAN SHI LI PHARMACEUTICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
A61K31/23; A61K9/08; A61K9/19; A61K47/24; A61K47/28; A61P35/00; C07C67/08; C07C69/24
Domestic Patent References:
| WO2007059118A1 | 2007-05-24 |
Foreign References:
| CN101327190A | 2008-12-24 |
Attorney, Agent or Firm:
SHANGHAI SSH INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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