Title:
COMMON LIGAND MIMICS: NAPHTOATES
Document Type and Number:
WIPO Patent Application WO2003083063
Kind Code:
A3
Abstract:
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affinity and/or selectivity of ligand binding to a receptor or receptor family through the synergistic action of the common ligand mimic and specificity ligand which compose the bi-ligand. The present invention also provides combinatorial libraries containing the common ligand mimics and bi-ligands of the invention. Further, the present invention provides methods for manufacturing the common ligand mimics and bi-ligands of the invention and methods for assaying the combinatorial libraries of the invention.
Inventors:
LANG HENGYUAN (US)
CHANG EDCON (US)
CEFALO DUSTIN (US)
FRYSZMAN OLGA (US)
YU LIN (US)
CHANG EDCON (US)
CEFALO DUSTIN (US)
FRYSZMAN OLGA (US)
YU LIN (US)
Application Number:
PCT/US2003/009086
Publication Date:
April 15, 2004
Filing Date:
March 21, 2003
Export Citation:
Assignee:
TRIAD THERAPEUTICS INC (US)
LANG HENGYUAN (US)
CHANG EDCON (US)
CEFALO DUSTIN (US)
FRYSZMAN OLGA (US)
YU LIN (US)
LANG HENGYUAN (US)
CHANG EDCON (US)
CEFALO DUSTIN (US)
FRYSZMAN OLGA (US)
YU LIN (US)
International Classes:
C07C65/11; C07C69/94; C07C205/59; C07C229/18; C07C229/56; C07C235/66; C07C311/29; C07D209/14; C07D213/79; C07D233/54; C07D249/12; C07D257/04; C07D309/30; C07D319/06; C40B40/04; C40B50/14; G01N33/573; (IPC1-7): C07C39/12
Foreign References:
| US2848296A | 1958-08-19 | |||
| US5344843A | 1994-09-06 | |||
| US3285706A | 1966-11-15 | |||
| US4002675A | 1977-01-11 | |||
| US6297348B1 | 2001-10-02 |
Other References:
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DATABASE CAPLUS [online] GOROG ET AL.: "Herbicide antidote for plants", XP002972020, accession no. STN Database accession no. 1983:102692
DATABASE CAPLUS [online] KAWABE ET AL.: "Photosensitive composition of polymer having alicyclic backbone for positively working photoresist", XP002972021, accession no. STN Database accession no. 1999:781001
DATABASE CAPLUS [online] KUDARI ET AL.: "Synthesis of a new series of 1,8-bis(5-aryloxymethyl-1,3,4-oxadiazol-2-yl) octanes and 1,8-bis(5-aryloxymethyl-4-amino/anilino-1,24-triazol-2-yl) octanes", XP002972022, accession no. STN Database accession no. 1998:125272
DATABASE CAPLUS [online] SHARMA ET AL.: "Facile reduction of carboxylic acid imidazolides to primary alcohols in the presence of water", XP002972023, accession no. STN Database accession no. 1995:809508
DATABASE CAPLUS [online] LITVAK ET AL.: "Substitution of an ester group for the halogen atom in 1-bromonaphthalene in the presence of molybdenum hexacarbonyl", XP002971471, accession no. STN Database accession no. 1980:550031
DATABASE CAPLUS [online] LU ET AL.: "Synthesis of alkyl aryl ethers by phase transfer catalysis", XP002972024, accession no. STN Database accession no. 1996:158293
DATABASE CAPLUS [online] HAHN: "Arylamides of 2-naphthol-1-carboxylic acid", XP002972025, accession no. STN Database accession no. 1957:81756
DATABASE CAPLUS [online] PAVLIDIS ET AL.: "Synthesis of aliphatic amines related to monodansylcadaverine via the oxidative rearrangement of aliphati amides with phenyliodosyl bis(trifluoracetate)", accession no. STN Database accession no. 1989:172769
DATABASE CAPLUS [online] CRISAN ET AL.: "Method of preparation of 1,4-dihydroxy-2-naphthoic acid", XP002972026, accession no. STN Database accession no. 1988:610742
DATABASE CAPLUS [online] BEKHLI ET AL.: "Synthesis of benzo(g)quinoline derivatives. I. 1,2,3,4-tetrahydro-4-oxobenzo(g)quinoline", XP002972027, accession no. STN Database accession no. 1969:106340
DATABASE CAPLUS [online] OSTAPCHUK ET AL.: "Benzindoles. 24 Synthesis and certain properties of 5,6-benzotryptamine hydrochloride", XP002972028, accession no. STN Database accession no. 1984:454844
DATABASE CAPLUS [online] KAWANAKA ET AL.: "Candida lipolytica HNA-110 strain and manufacture of 2,6-dihydroxy-3-naphthoic acid with candida species", XP002972029, accession no. STN Database accession no. 1998:55765
DATABASE CAPLUS [online] MISHRA ET AL.: "Use of some phenolic and pyrazolone derivatives as acid-base indicators", XP002972030, accession no. STN Database accession no. 1978:181806
DATABASE CAPLUS [online] KOSUGI ET AL.: "preparation of aromatic hydroxy carboxylic acids", XP002972031, accession no. STN Database accession no. 1999:409253
DATABASE CAPLUS [online] NAKANISHI ET AL.: "Process for controlling the isomer ratio of aromatic hydrocarboxylic acids in the carboxylation of alkali phenolates in phosphine oxide solvents", XP002972032, accession no. STN Database accession no. 1992:235255
DATABASE CAPLUS [online] SEKINE ET AL.: "Preparation of heterocycle-containing naphthoic acid derivatives as 5-lipoxygenase inhibitors and allergy inhibitors", XP002972033, accession no. STN Database accession no. 1993:603438
DATABASE CAPLUS [online] GOROG ET AL.: "Herbicide antidote for plants", XP002972020, accession no. STN Database accession no. 1983:102692
DATABASE CAPLUS [online] KAWABE ET AL.: "Photosensitive composition of polymer having alicyclic backbone for positively working photoresist", XP002972021, accession no. STN Database accession no. 1999:781001
DATABASE CAPLUS [online] KUDARI ET AL.: "Synthesis of a new series of 1,8-bis(5-aryloxymethyl-1,3,4-oxadiazol-2-yl) octanes and 1,8-bis(5-aryloxymethyl-4-amino/anilino-1,24-triazol-2-yl) octanes", XP002972022, accession no. STN Database accession no. 1998:125272
DATABASE CAPLUS [online] SHARMA ET AL.: "Facile reduction of carboxylic acid imidazolides to primary alcohols in the presence of water", XP002972023, accession no. STN Database accession no. 1995:809508
DATABASE CAPLUS [online] LITVAK ET AL.: "Substitution of an ester group for the halogen atom in 1-bromonaphthalene in the presence of molybdenum hexacarbonyl", XP002971471, accession no. STN Database accession no. 1980:550031
DATABASE CAPLUS [online] LU ET AL.: "Synthesis of alkyl aryl ethers by phase transfer catalysis", XP002972024, accession no. STN Database accession no. 1996:158293
DATABASE CAPLUS [online] HAHN: "Arylamides of 2-naphthol-1-carboxylic acid", XP002972025, accession no. STN Database accession no. 1957:81756
DATABASE CAPLUS [online] PAVLIDIS ET AL.: "Synthesis of aliphatic amines related to monodansylcadaverine via the oxidative rearrangement of aliphati amides with phenyliodosyl bis(trifluoracetate)", accession no. STN Database accession no. 1989:172769
DATABASE CAPLUS [online] CRISAN ET AL.: "Method of preparation of 1,4-dihydroxy-2-naphthoic acid", XP002972026, accession no. STN Database accession no. 1988:610742
DATABASE CAPLUS [online] BEKHLI ET AL.: "Synthesis of benzo(g)quinoline derivatives. I. 1,2,3,4-tetrahydro-4-oxobenzo(g)quinoline", XP002972027, accession no. STN Database accession no. 1969:106340
DATABASE CAPLUS [online] OSTAPCHUK ET AL.: "Benzindoles. 24 Synthesis and certain properties of 5,6-benzotryptamine hydrochloride", XP002972028, accession no. STN Database accession no. 1984:454844
DATABASE CAPLUS [online] KAWANAKA ET AL.: "Candida lipolytica HNA-110 strain and manufacture of 2,6-dihydroxy-3-naphthoic acid with candida species", XP002972029, accession no. STN Database accession no. 1998:55765
DATABASE CAPLUS [online] MISHRA ET AL.: "Use of some phenolic and pyrazolone derivatives as acid-base indicators", XP002972030, accession no. STN Database accession no. 1978:181806
DATABASE CAPLUS [online] KOSUGI ET AL.: "preparation of aromatic hydroxy carboxylic acids", XP002972031, accession no. STN Database accession no. 1999:409253
DATABASE CAPLUS [online] NAKANISHI ET AL.: "Process for controlling the isomer ratio of aromatic hydrocarboxylic acids in the carboxylation of alkali phenolates in phosphine oxide solvents", XP002972032, accession no. STN Database accession no. 1992:235255
DATABASE CAPLUS [online] SEKINE ET AL.: "Preparation of heterocycle-containing naphthoic acid derivatives as 5-lipoxygenase inhibitors and allergy inhibitors", XP002972033, accession no. STN Database accession no. 1993:603438
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