COMPLETELY-SOLID-PHASE PREPARATION METHOD FOR CARBETOCIN

Title:

COMPLETELY-SOLID-PHASE PREPARATION METHOD FOR CARBETOCIN

Document Type and Number:

WIPO Patent Application WO/2017/097194

Kind Code:

A1

Abstract:

Provided is a completely-solid-phase preparation method for carbetocin, comprising: first, coupling chloro-butyric acid to tyrosine amino of a peptide chain through an amide coupling agent; and then, performing solid-phase cyclization by using DBU as a base to obtain a crude carbetocin peptide.

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Inventors:

YAO ZHIJUN (CN)
MA JINGSI (CN)
WU KEJIN (CN)
MI PENGCHENG (CN)
TAO ANJIN (CN)
YUAN JIANCHENG (CN)

Application Number:

PCT/CN2016/108824

Publication Date:

June 15, 2017

Filing Date:

December 07, 2016

Export Citation:

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Assignee:

HYBIO PHARMACEUTICAL CO LTD (CN)

International Classes:

C07K7/16; C07K1/04; C07K1/06

Foreign References:

CN101555272A	2009-10-14
CN104592362A	2015-05-06
CN102260326A	2011-11-30
CN102796178A	2012-11-28
CN103992390A	2014-08-20

Attorney, Agent or Firm:

BEIJING CHENGHUI LAW FIRM (CN)

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