Title:
COMPLEX COMPRISING BOTH HEPARIN BINDING PROTEINS AND HEPARIN-HYDROXYALKYL STARCH CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2009/135888
Kind Code:
A3
Abstract:
A complex comprising at least one target protein and at least one binding molecule having a binding affinity for said target protein, wherein said molecule having a binding affinity is covalently or non-covalently bound to at least one water-soluble polymer. In specific embodiments, the invention is directed to a complex comprising at least one protein with a heparin binding site and at least one heparin or a heparin-like molecule, wherein the heparin or heparin-like molecule is covalently bound to hydroxyalkyl starch.
Inventors:
HABERL UDO (DE)
FRANK HANS-GEORG (NL)
POETGENS ANDY (NL)
EMGENBROICH MARCO (DE)
RYBKA ANDREAS (DE)
SCHROEDER CAROLA (DE)
KANNICHT CHRISTOPH (DE)
WALTER OLAF (CH)
FRANK HANS-GEORG (NL)
POETGENS ANDY (NL)
EMGENBROICH MARCO (DE)
RYBKA ANDREAS (DE)
SCHROEDER CAROLA (DE)
KANNICHT CHRISTOPH (DE)
WALTER OLAF (CH)
Application Number:
PCT/EP2009/055503
Publication Date:
July 01, 2010
Filing Date:
May 06, 2009
Export Citation:
Assignee:
OCTAPHARMA AG (CH)
APLAGEN GMBH (DE)
HABERL UDO (DE)
FRANK HANS-GEORG (NL)
POETGENS ANDY (NL)
EMGENBROICH MARCO (DE)
RYBKA ANDREAS (DE)
SCHROEDER CAROLA (DE)
KANNICHT CHRISTOPH (DE)
WALTER OLAF (CH)
APLAGEN GMBH (DE)
HABERL UDO (DE)
FRANK HANS-GEORG (NL)
POETGENS ANDY (NL)
EMGENBROICH MARCO (DE)
RYBKA ANDREAS (DE)
SCHROEDER CAROLA (DE)
KANNICHT CHRISTOPH (DE)
WALTER OLAF (CH)
International Classes:
A61K47/48; A61P7/00
Domestic Patent References:
| WO2006071801A2 | 2006-07-06 | |||
| WO2005014655A2 | 2005-02-17 | |||
| WO2005092928A1 | 2005-10-06 |
Other References:
YAMAGUCHI N ET AL: "Growth factor mediated assembly of cell receptor-responsive hydrogels", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 20070321 US, vol. 129, no. 11, 21 March 2007 (2007-03-21), pages 3040 - 3041, XP002573016, ISSN: 0002-7863
LARIONOVA N I ET AL: "CONJUGATION OF THE BOWMAN-BIRK SOYBEAN PROTEINASE INHIBITOR WITH HYDROXYETHYLSTARCH", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS, INC, US, vol. 62, no. 2/03, 1 January 1997 (1997-01-01), pages 175 - 182, XP001122297, ISSN: 0273-2289
KE S ET AL: "Intermolecular interaction of avidin and PEGylated biotin", BIOCONJUGATE CHEMISTRY 200711 US, vol. 18, no. 6, November 2007 (2007-11-01), pages 2109 - 2114, XP002573017, ISSN: 1043-1802
MAYNARD H D ET AL: "Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 1, no. 4, 1 July 2005 (2005-07-01), pages 451 - 459, XP025338363, ISSN: 1742-7061, [retrieved on 20050701]
VAN DIJK K. ET AL.: "Factor VIII half life and clinical phenotype of severe hemophilia A", HAEMATOLOGICA, vol. 90, no. 4, April 2005 (2005-04-01), pages 494 - 498, XP002497580
LARIONOVA N I ET AL: "CONJUGATION OF THE BOWMAN-BIRK SOYBEAN PROTEINASE INHIBITOR WITH HYDROXYETHYLSTARCH", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS, INC, US, vol. 62, no. 2/03, 1 January 1997 (1997-01-01), pages 175 - 182, XP001122297, ISSN: 0273-2289
KE S ET AL: "Intermolecular interaction of avidin and PEGylated biotin", BIOCONJUGATE CHEMISTRY 200711 US, vol. 18, no. 6, November 2007 (2007-11-01), pages 2109 - 2114, XP002573017, ISSN: 1043-1802
MAYNARD H D ET AL: "Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 1, no. 4, 1 July 2005 (2005-07-01), pages 451 - 459, XP025338363, ISSN: 1742-7061, [retrieved on 20050701]
VAN DIJK K. ET AL.: "Factor VIII half life and clinical phenotype of severe hemophilia A", HAEMATOLOGICA, vol. 90, no. 4, April 2005 (2005-04-01), pages 494 - 498, XP002497580
Attorney, Agent or Firm:
ROTH, Carla et al. (Lohengrinstrasse 11, Düsseldorf, DE)
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