Title:
COMPLEX COMPRISING WATER-SOLUBLE FRAGMENTS OF FCΕRI AND COMPOSITION COMPRISING SAME FOR TREATING ALLERGIC DISEASES MEDIATED BY IGE
Document Type and Number:
WIPO Patent Application WO/2012/169735
Kind Code:
A2
Abstract:
The present invention relates to a complex in which water-soluble fragments of FcεRI, which is a receptor having a high affinity to the Fc region of immunoglobulin E (IgE), are bound with a material having biocompatibility. The complex in which the water-soluble fragments of FcεRI are bound with the material having biocompatibility according to the present invention inhibits the coupling of IgE and the FcεRI, which is a receptor of the IgE, so as to suppress the secretion of allergic cytokine. Thus, the complex has the effect of treating and preventing allergic diseases.
Inventors:
PARK BYEONG-DEOG (KR)
YOON SEON JOO (KR)
KIM WOOK-DONG (KR)
BAE JONG HWAN (KR)
KIM MIN HEE (KR)
KANG HYUN JUNG (KR)
PARK EUN HYE (KR)
YOON SEON JOO (KR)
KIM WOOK-DONG (KR)
BAE JONG HWAN (KR)
KIM MIN HEE (KR)
KANG HYUN JUNG (KR)
PARK EUN HYE (KR)
Application Number:
PCT/KR2012/004075
Publication Date:
December 13, 2012
Filing Date:
May 23, 2012
Export Citation:
Assignee:
NEOPHARM CO LTD (KR)
PARK BYEONG-DEOG (KR)
YOON SEON JOO (KR)
KIM WOOK-DONG (KR)
BAE JONG HWAN (KR)
KIM MIN HEE (KR)
KANG HYUN JUNG (KR)
PARK EUN HYE (KR)
PARK BYEONG-DEOG (KR)
YOON SEON JOO (KR)
KIM WOOK-DONG (KR)
BAE JONG HWAN (KR)
KIM MIN HEE (KR)
KANG HYUN JUNG (KR)
PARK EUN HYE (KR)
International Classes:
A61K38/00; A61K38/16; A61K39/395; A61K47/30; A61K47/48
Foreign References:
| KR100502879B1 | 2005-07-25 | |||
| US20050170451A1 | 2005-08-04 | |||
| KR100464699B1 | 2005-07-28 |
Other References:
STEPHEN J. DEMAREST ET AL.: 'An Intermediate pH Unfolding Transition Abrogates the Ability of IgE to IOnteract with Its High Affinity Receptor FcepcilronRlalpha' JBC vol. 281, no. 41, 2006, pages 30755 - 30767
Attorney, Agent or Firm:
KWON, Oh-Sig et al. (KR)
권오식 (KR)
권오식 (KR)
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Claims: