Title:
COMPLEX AND PHOTOIMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2022/054798
Kind Code:
A1
Abstract:
Provided is a drug that is useful for photoimmunotherapy. Provided is a complex that contains an antibody molecule, particles having an average particle diameter of 100 nm or less, and a photoreceptive site. In the complex, the particles having an average particle diameter of 100 nm or less are bonded to the antibody molecule, and at least one of either the antibody molecule or the particles are bonded to the photoreceptive site. The photoreceptive site is a site having hydrophobic properties that are increased by irradiation with a light beam having a wavelength of 500-900 nm or a site that includes a phthalocyanine skeleton.
Inventors:
SATO KAZUHIDE (JP)
YUKAWA HIROSHI (JP)
MATSUOKA KOHEI (JP)
UEYA YUUICHI (JP)
SHIMADA MIBUKO (JP)
ONO KENICHIRO (JP)
YUKAWA HIROSHI (JP)
MATSUOKA KOHEI (JP)
UEYA YUUICHI (JP)
SHIMADA MIBUKO (JP)
ONO KENICHIRO (JP)
Application Number:
PCT/JP2021/032856
Publication Date:
March 17, 2022
Filing Date:
September 07, 2021
Export Citation:
Assignee:
JSR CORP (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
A61K47/50; A61K39/395; A61K41/00; A61K49/16; A61P35/00; A61P37/04; A61P43/00; G01N33/53
Foreign References:
| JP2014523907A | 2014-09-18 | |||
| US7005518B2 | 2006-02-28 |
Other References:
SATO KAZUHIDE: "A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy", THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, vol. 41, no. 2, 1 July 2020 (2020-07-01), pages 104 - 109, XP055911791
HISATAKA KOBAYASHI, AKI FURUSAWA, ADRIAN ROSENBERG, PETER L CHOYKE: "Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity", INTERNATIONAL IMMUNOLOGY, vol. 33, no. 1, 4 June 2020 (2020-06-04), pages 7 - 15, XP055756069, DOI: 10.1093/intimm/dxaa037
I-MING CHU, TSENG SHIH-HENG, CHOU MIN-YUAN: "Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 10, 1 May 2015 (2015-05-01), pages 3663 - 3685, XP055553772, DOI: 10.2147/IJN.S80134
LIN RUN, HUANG JING, WANG LIYA, LI YUANCHENG, LIPOWSKA MALGORZATA, WU HUI, YANG JIANYONG, MAO HUI: "Bevacizumab and near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor targeted MR and optical imaging", BIOMATERIALS SCIENCE, vol. 6, no. 6, 1 January 2018 (2018-01-01), GB , pages 1517 - 1525, XP055911818, ISSN: 2047-4830, DOI: 10.1039/C8BM00225H
WANG YABIN, CHEN JIANGWEI, YANG BO, QIAO HONGYU, GAO LEI, SU TAO, MA SAI, ZHANG XIAOTIAN, LI XIUJUAN, LIU GANG, CAO JIANBO, CHEN X: "In vivo MR and Fluorescence Dual-modality Imaging of Atherosclerosis Characteristics in Mice Using Profilin-1 Targeted Magnetic Nanoparticles", THERANOSTICS, vol. 6, no. 2, 1 January 2016 (2016-01-01), AU , pages 272 - 286, XP055911836, ISSN: 1838-7640, DOI: 10.7150/thno.13350
ANONYMOUS: "Abstract 4512: Super-enhanced permeability and retention (SUPR) effect induced by photo-immunotherapy (PIT) can accommodate massive nano-sized reagents deep into tumors. | Cancer Research", 15 April 2013 (2013-04-15), XP055282456, Retrieved from the Internet [retrieved on 20160621]
"A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy", THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, vol. 41, no. 2, 2020, pages 104 - 109
"GenBank", Database accession no. NM_000417.2
E. W. MARTIN: "Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING CO.
HISATAKA KOBAYASHI, AKI FURUSAWA, ADRIAN ROSENBERG, PETER L CHOYKE: "Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity", INTERNATIONAL IMMUNOLOGY, vol. 33, no. 1, 4 June 2020 (2020-06-04), pages 7 - 15, XP055756069, DOI: 10.1093/intimm/dxaa037
I-MING CHU, TSENG SHIH-HENG, CHOU MIN-YUAN: "Cetuximab-conjugated iron oxide nanoparticles for cancer imaging and therapy", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 10, 1 May 2015 (2015-05-01), pages 3663 - 3685, XP055553772, DOI: 10.2147/IJN.S80134
LIN RUN, HUANG JING, WANG LIYA, LI YUANCHENG, LIPOWSKA MALGORZATA, WU HUI, YANG JIANYONG, MAO HUI: "Bevacizumab and near infrared probe conjugated iron oxide nanoparticles for vascular endothelial growth factor targeted MR and optical imaging", BIOMATERIALS SCIENCE, vol. 6, no. 6, 1 January 2018 (2018-01-01), GB , pages 1517 - 1525, XP055911818, ISSN: 2047-4830, DOI: 10.1039/C8BM00225H
WANG YABIN, CHEN JIANGWEI, YANG BO, QIAO HONGYU, GAO LEI, SU TAO, MA SAI, ZHANG XIAOTIAN, LI XIUJUAN, LIU GANG, CAO JIANBO, CHEN X: "In vivo MR and Fluorescence Dual-modality Imaging of Atherosclerosis Characteristics in Mice Using Profilin-1 Targeted Magnetic Nanoparticles", THERANOSTICS, vol. 6, no. 2, 1 January 2016 (2016-01-01), AU , pages 272 - 286, XP055911836, ISSN: 1838-7640, DOI: 10.7150/thno.13350
ANONYMOUS: "Abstract 4512: Super-enhanced permeability and retention (SUPR) effect induced by photo-immunotherapy (PIT) can accommodate massive nano-sized reagents deep into tumors. | Cancer Research", 15 April 2013 (2013-04-15), XP055282456, Retrieved from the Internet
"A Mechanism of Cancer Cell Cytotoxicity of Near-Infrared Photoimmunotherapy", THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE, vol. 41, no. 2, 2020, pages 104 - 109
"GenBank", Database accession no. NM_000417.2
E. W. MARTIN: "Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING CO.
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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