Title:
COMPLEX OR SALT THEREOF, AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2022/196675
Kind Code:
A1
Abstract:
The present invention provides a highly controlled complex containing antibodies and ferritin particles. More specifically, the present invention provides (I) and (II) below. (I) A complex or a salt thereof containing: (A) one IgG antibody; and (B) two human ferritin particles containing one or more human ferritin H chains linked to the one IgG antibody. (II) A method for manufacturing a complex or salt thereof containing (1)-(3) below. (1) A first reactive group is introduced into an IgG antibody to produce a modified IgG antibody containing two first reactive groups; (2) a second reactive group that is capable of reacting with the first reactive group is introduced into human ferritin particles containing one or more human ferritin H chains so as to generate modified particles containing one or more modified human ferritin H chains containing a second reactive group; and (3) the modified IgG antibody is reacted with the modified particles to obtain the complex.
Inventors:
YAMADA KEI (JP)
MATSUDA YUTAKA (JP)
INOUE IPPEI (JP)
SHIKIDA NATSUKI (JP)
SHIMBO KAZUTAKA (JP)
MATSUDA YUTAKA (JP)
INOUE IPPEI (JP)
SHIKIDA NATSUKI (JP)
SHIMBO KAZUTAKA (JP)
Application Number:
PCT/JP2022/011534
Publication Date:
September 22, 2022
Filing Date:
March 15, 2022
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C07K14/47; C07K16/00; C12N15/12
Domestic Patent References:
| WO2016122259A1 | 2016-08-04 | |||
| WO2019163871A1 | 2019-08-29 | |||
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| WO2020090708A1 | 2020-05-07 | |||
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R. TALANIAN ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 9677
X. MENG ET AL., NANOSCALE, vol. 3, no. 3, 2011, pages 977
E. FALVO ET AL., BIOMACROMOLECULES, vol. 17, no. 2, 2016, pages 514
Z. GUO ET AL., BIOMED. REP., vol. 4, no. 5, 2016, pages 528
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BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
DUBOWCHIK ET AL., PHARMA. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
BOUTUREIRA ET AL., CHEM REV, vol. 115, 2015, pages 2174 - 2195
ANAL. CHEM., vol. 91, no. 20, 2019, pages 12724 - 12732
ELISABETTA FALVO, ELISA TREMANTE, ROCCO FRAIOLI, CARLO LEONETTI, CARLOTTA ZAMPARELLI, ALBERTO BOFFI, VERONICA MOREA, PIERPAOLO CEC: "Antibody–drug conjugates: targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin", NANOSCALE, vol. 5, no. 24, 1 January 2013 (2013-01-01), pages 12278, XP055195379, ISSN: 20403364, DOI: 10.1039/c3nr04268e
KHOSHNEJAD MAKAN, GREINEDER COLIN F, PULSIPHER KATHERINE W, VILLA CARLOS H, ALTUN BURCIN, PAN DANIEL C, TSOURKAS ANDREW, DMOCHOWSK: "Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging", BIOCONJUG. CHEM., vol. 29, no. 4, 18 April 2018 (2018-04-18), pages 1209 - 1218, XP055967961, DOI: 10.1021/acs.bioconjchem.8b00004
PROC NATL ACAD SCI USA, vol. 71, no. 5, 1974, pages 2033 - 2037
BIOCONJ. CHEM, vol. 29, no. 4, 2018, pages 1209 - 1218
NANOSCALE, vol. 5, no. 24, 2013, pages 12278 - 85
JAE OG JEON ET AL., ACS NANO, vol. 7, no. 9, 2013, pages 7462 - 7471
SOOJI KIM ET AL., BIOMATERIALS, vol. 17, no. 3, 2016, pages 1150 - 1159
YOUNG JI KANG ET AL., BIOMATERIALS, vol. 13, no. 12, 2012, pages 4057 - 4064
L. LI ET AL., PROC NATL ACAD SCI USA., vol. 107, no. 8, 2010, pages 3505 - 10
F. DANHIER ET AL., MOL. PHARMACEUTICS, vol. 9, no. 11, 2012, pages 2961
C-H. WU ET AL., SCI. TRANSL. MED., vol. 7, no. 290, 2015, pages 290 - 91
L. VANNUCCI ET AL., INT. J. NANOMEDICINE, vol. 7, 2012, pages 1489
J. CUTRERA ET AL., MOL. THER., vol. 19, no. 8, 2011, pages 1468
R. LIU ET AL., DV. DRUG DELIV. REV., vol. 110-111, 2017, pages 13
R. TAN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 5282
R. TAN ET AL., CELL, vol. 73, 1993, pages 1031
R. TALANIAN ET AL., BIOCHEMISTRY, vol. 31, 1992, pages 6871
K. OLDENBURG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, no. 12, 1992, pages 5393 - 5397
K. YAMAMOTO ET AL., J. BIOCHEM., vol. 111, 1992, pages 436
A. BAIMIEV ET AL., MOL. BIOL. (MOSCOW, vol. 39, no. 1, 2005, pages 90
O. KRUSE ET AL., B Z. NATURFORSCH., vol. 50c, 1995, pages 380
O. SILVA ET AL., SCI. REP., vol. 6, 2016, pages 27128
A. FILOTEO, J. BIOL. CHEM., vol. 267, no. 17, 1992, pages 11800
D. MCILWAIN1 ET AL., COLD SPRING HARB PERSPECT BIOL., vol. 5, 2013, pages a008656
V. STOKA ET AL., IUBMB LIFE, vol. 57, no. 4-5, 2005, pages 347
G. LEE ET AL., EUR J PHARM BIOPHARM., vol. 67, no. 3, 2007, pages 646
R. JENNY ET AL., PROTEIN EXPR. PURIF., vol. 31, no. 1, 2003, pages 1
H. XU ET AL., J. VIROL., vol. 84, no. 2, 2010, pages 1076
C. BYRD ET AL., DRUG DEV. RES., vol. 67, 2006, pages 501
E. LEE ET AL., ADV. FUNCT. MATER., vol. 25, 2015, pages 1279
Y. KANG ET AL., BIOMACROMOLECULES, vol. 13, no. 12, 2012, pages 4057
R. TALANIAN ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 9677
X. MENG ET AL., NANOSCALE, vol. 3, no. 3, 2011, pages 977
E. FALVO ET AL., BIOMACROMOLECULES, vol. 17, no. 2, 2016, pages 514
Z. GUO ET AL., BIOMED. REP., vol. 4, no. 5, 2016, pages 528
JOURNAL OF CONTROLLED RELEASE, vol. 196, 2014, pages 184 - 196
BIOMACROMICS, vol. 17, 2016, pages 514 - 522
PROC NATL ACAD SCI USA., vol. 111, no. 41, 2014, pages 14900 - 5
SHARPLESS K. B. ET AL., ANGEW. CHEM. INT. ED., vol. 40, 2015, pages 2004
BERTOZZI C. R. ET AL., SCIENCE, vol. 291, 2001, pages 2357
BERTOZZI C. R. ET AL., NATURE CHEMICAL BIOLOGY, vol. 1, 2005, pages 13
DUBOWCHIK ET AL., PHARMA. THERAPEUTICS, vol. 83, 1999, pages 67 - 123
BOUTUREIRA ET AL., CHEM REV, vol. 115, 2015, pages 2174 - 2195
ANAL. CHEM., vol. 91, no. 20, 2019, pages 12724 - 12732
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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