Title:
COMPLEXED POLYPEPTIDE AND ADJUVANT FOR IMPROVED VACCINES
Document Type and Number:
WIPO Patent Application WO2005076975
Kind Code:
A3
Abstract:
Attachment of the strongly immunogenic polypeptide to a more weakly immunogenic polypeptide can precipitate and focus a CpG adjuvant to increase in vivo priming of a cytotoxic T-lymphocyte (CTL) response, and thus increase the immunogenicity of the more weakly immunogenic polypeptide. Accordingly, compositions that include a bipartite immunogenic polypeptide are provided herein. The bipartite polypeptide can include a CpG-interacting amino acid sequence fused to a CTL-activating amino acid sequence that can be heterologous to the CpG-interacting amino acid sequence. Also provided are methods of identifying and using a CpG-interacting amino acid sequence and a bipartite immunogenic polypeptide.
Inventors:
WETTSTEIN PETER J (US)
STRAUSBAUCH MIKE (US)
HARDIN HEATHER (US)
BORSON NANCY (US)
STRAUSBAUCH MIKE (US)
HARDIN HEATHER (US)
BORSON NANCY (US)
Application Number:
PCT/US2005/003754
Publication Date:
November 10, 2005
Filing Date:
February 04, 2005
Export Citation:
Assignee:
MAYO FOUNDATION (US)
WETTSTEIN PETER J (US)
STRAUSBAUCH MIKE (US)
HARDIN HEATHER (US)
BORSON NANCY (US)
WETTSTEIN PETER J (US)
STRAUSBAUCH MIKE (US)
HARDIN HEATHER (US)
BORSON NANCY (US)
International Classes:
A61K39/00; A61K39/385; A61K45/00; A61K47/00; C12Q1/68; (IPC1-7): A61K39/00; A61K39/385; A61K45/00; A61K47/00; C12Q1/68
Other References:
SCHIRMBECK R. ET AL: "Antigenic Epitopes Fused to Cationic Peptide Bound to Oligonucleotides Facilitate Toll-Like Receptor 9-Dependent, but CD4+T Cell Help-Independent, Priming of CD8+T Cells.", THE JOURNAL OF IMMUNOLOGY., vol. 171, no. 10, 15 November 2003 (2003-11-15), pages 5198 - 5207, XP002333112
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