Title:
COMPLEXES COMPRISING ANGIOSTATIN AND ITS FRAGMENTS, PREPARATION PREPARING METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/083615
Kind Code:
A1
Abstract:
A medicament useful for treating tumors or angiogenesis mediated diseases,
medical compositions and kits comprising the medicament and a method for preparing
the medicament are provided. The medicament contains complexes of a modifier
and angiostatin or its fragments, which have longer in vivo half-life than non-modified
angiostatin or its fragments. The modifier is selected from high molecular polymers,
proteins or their fragments, polypeptides, small molecules and any other type
of compounds.
Inventors:
LUO YONGZHANG (CN)
CHANG GUODONG (CN)
YANG SHULING (CN)
GAO LEI (CN)
FU YAN (CN)
CHANG GUODONG (CN)
YANG SHULING (CN)
GAO LEI (CN)
FU YAN (CN)
Application Number:
PCT/CN2008/000067
Publication Date:
July 17, 2008
Filing Date:
January 10, 2008
Export Citation:
Assignee:
PROTGEN LTD (CN)
LUO YONGZHANG (CN)
CHANG GUODONG (CN)
YANG SHULING (CN)
GAO LEI (CN)
FU YAN (CN)
LUO YONGZHANG (CN)
CHANG GUODONG (CN)
YANG SHULING (CN)
GAO LEI (CN)
FU YAN (CN)
International Classes:
A61K38/18; C07K17/08; A61K47/48; A61P35/00; C07K1/107; C07K1/18; C07K14/515
Domestic Patent References:
| WO2002026782A2 | 2002-04-04 | |||
| WO2005047336A1 | 2005-05-26 | |||
| WO1999039732A1 | 1999-08-12 | |||
| WO2005077421A1 | 2005-08-25 | |||
| WO2004076474A2 | 2004-09-10 | |||
| WO2005011107A1 | 2005-02-03 | |||
| WO2005063808A1 | 2005-07-14 | |||
| WO2005047337A1 | 2005-05-26 | |||
| WO2001017568A2 | 2001-03-15 | |||
| WO2002026782A2 | 2002-04-04 |
Foreign References:
| CN1443194A | 2003-09-17 | |||
| US6949511B1 | 2005-09-27 | |||
| CN1824775A | 2006-08-30 | |||
| US6689762B1 | 2004-02-10 | |||
| US20040030101A1 | 2004-02-12 | |||
| EP0593868A1 | 1994-04-27 | |||
| EP1571212A1 | 2005-09-07 | |||
| CN1616087A | 2005-05-18 | |||
| US4911929A | 1990-03-27 | |||
| US7157556B1 | 2007-01-02 |
Other References:
WU J. ET AL.: "PEG Modification of Protein Drug", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 26, no. 3, March 2002 (2002-03-01), pages 146 - 151
FOLKMAN J., N ERLGL J MED, vol. 285, 1971, pages 1182 - 1186
O'REILLY MS; HOLMGREN L; SHING Y ET AL., CELL, vol. 79, 1994, pages 315 - 328
LERCH P G; RISKLI E E; LERGIER W ET AL., EUR J BIOCHEM, vol. 107, 1980, pages 7 - 13
CAO Y; JI RW; DAVIDSON D ET AL., J BIOL CHEM, vol. 271, no. 46, 1996, pages 294B1 - 29467
SIM BKL; O'REILLY MS ET AL., CANCER RES, vol. 57, 1997, pages 1329 - 1334
KIRSCH M; STRASSER J; ALLENDE R ET AL., J BIOL CHEM, vol. 271, no. 46, 1996, pages 29461 - 29467
FROKJAER S. ET AL., NAT. REV. DRUG DISCOV., vol. 4, 4 April 2005 (2005-04-04), pages 298 - 306
HARRIS JM. ET AL., NAT. REV. DRUG DISCOV., vol. 3, 2 March 2003 (2003-03-02), pages 214 - 21
VERONESE FM ET AL., DRUG DISCOV. TODAY, vol. 10, no. 21, 1 November 2005 (2005-11-01), pages 1451 - 8
GRAHANR ML, ADV. DRUG DELIV. REV., vol. 55, pages 1293 - 1302
LEVY Y ET AL., J. PEDIATR., vol. 113, pages 312 - 317
DAVIS S ET AL., CLINEXP. IMMUNOL., vol. 46, pages 649 - 652
HERSHFIELD MS ET AL., N ENGL J MED, vol. 316, pages 589 - 596
BAILON P ET AL., C. BIOCONJUG. CHEM., vol. 12, pages 195 - 202
WANG YS ET AL., ADV. DRUG DELIV. REV., vol. 54, pages 547 - 570
PEPPAS NA ET AL., EUR. J. PHARM. BIOPHARM., vol. 50, 2000, pages 27 - 46
PACKHAEUSER CB ET AL., EUR. J. PHARM. BIOPHARM., vol. 58, 2004, pages 445 - 455
METSELAAR JM ET AL., MINI REV. MED. CHEM., vol. 4, 2002, pages 319 - 329
CATTANEO MG ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 46, 15 November 1996 (1996-11-15), pages 29461 - 29467
See also references of EP 2113517A4
FOLKMAN J., N ERLGL J MED, vol. 285, 1971, pages 1182 - 1186
O'REILLY MS; HOLMGREN L; SHING Y ET AL., CELL, vol. 79, 1994, pages 315 - 328
LERCH P G; RISKLI E E; LERGIER W ET AL., EUR J BIOCHEM, vol. 107, 1980, pages 7 - 13
CAO Y; JI RW; DAVIDSON D ET AL., J BIOL CHEM, vol. 271, no. 46, 1996, pages 294B1 - 29467
SIM BKL; O'REILLY MS ET AL., CANCER RES, vol. 57, 1997, pages 1329 - 1334
KIRSCH M; STRASSER J; ALLENDE R ET AL., J BIOL CHEM, vol. 271, no. 46, 1996, pages 29461 - 29467
FROKJAER S. ET AL., NAT. REV. DRUG DISCOV., vol. 4, 4 April 2005 (2005-04-04), pages 298 - 306
HARRIS JM. ET AL., NAT. REV. DRUG DISCOV., vol. 3, 2 March 2003 (2003-03-02), pages 214 - 21
VERONESE FM ET AL., DRUG DISCOV. TODAY, vol. 10, no. 21, 1 November 2005 (2005-11-01), pages 1451 - 8
GRAHANR ML, ADV. DRUG DELIV. REV., vol. 55, pages 1293 - 1302
LEVY Y ET AL., J. PEDIATR., vol. 113, pages 312 - 317
DAVIS S ET AL., CLINEXP. IMMUNOL., vol. 46, pages 649 - 652
HERSHFIELD MS ET AL., N ENGL J MED, vol. 316, pages 589 - 596
BAILON P ET AL., C. BIOCONJUG. CHEM., vol. 12, pages 195 - 202
WANG YS ET AL., ADV. DRUG DELIV. REV., vol. 54, pages 547 - 570
PEPPAS NA ET AL., EUR. J. PHARM. BIOPHARM., vol. 50, 2000, pages 27 - 46
PACKHAEUSER CB ET AL., EUR. J. PHARM. BIOPHARM., vol. 58, 2004, pages 445 - 455
METSELAAR JM ET AL., MINI REV. MED. CHEM., vol. 4, 2002, pages 319 - 329
CATTANEO MG ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 46, 15 November 1996 (1996-11-15), pages 29461 - 29467
See also references of EP 2113517A4
Attorney, Agent or Firm:
NTD PATENT & TRADEMARK AGENCY LIMITED BEIJING OFFICE (Block AInvestment Plaza,27 Jinrongdajie, Beijing 2, CN)
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