COMPOSITE MATERIAL AND ITS PREPRATION, USING IN TUMOR THERAPY AND AITITUMOR MEDICINE

WIPO Patent Application WO/2010/040312

A1

A method relates to the preparation of hollow submicron silicon dioxide sphere coated gold shell and the use for preparing antitumor medicine. The hollow submicron silicon dioxide sphere is made as core and the gold shell is coated uniformly on the surface of the sphere. The antitumor medicine is loaded on the hollow submicron silicon dioxide sphere and the tumor specific targeting agent is coupled with the surface of the gold shell. The particle size of the hollow submicron silicon dioxide sphere and the thickness of the gold shell are controllable. Based on the Mie Scattering Theory, the hollow submicron silicon dioxide sphere coated gold shell can adjust its absorption in near-infrared area and converts light energy of infrared laser into peripheral heat which can kill the malignant tumor cell. The hollow submicron silicon dioxide sphere can be used as a slow-release carrier of therapeutic medicine, and the tumor specific targeting agent coupled with the surface of the gold shell can make the medicine have the function of targeting.

CHEN DONG (CN)
ZHANG YANGDE (CN)
TANG FANGQIONG (CN)
LIU HUIYU (CN)
LI LINLIN (CN)
MENG XIANWEI (CN)
ZHANG ZONGJIU (CN)

PCT/CN2009/074306

April 15, 2010

September 29, 2009

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CHEN DONG (CN)
ZHANG YANGDE (CN)
TANG FANGQIONG (CN)
LIU HUIYU (CN)
LI LINLIN (CN)
MENG XIANWEI (CN)
ZHANG ZONGJIU (CN)

A61K47/04; A61K31/337; A61K31/7076; C01B33/113

CN101121519A	2008-02-13
CN101049631A	2007-10-10
CN101168597A	2008-04-30
CN101168062A	2008-04-30
US6479146B1	2002-11-12

RUNPING & PARTNERS (Yingu Mansion No.9 Beisihuanxilu Haidian District, Beijing 0, CN)

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