Title:
COMPOSITE NANOPARTICULATE MINERALIZED COLLAGEN GLYCOSAMINOGLYCAN MATERIALS WITH TIME RELEASE ANTI-RESORPTIVE FACTORS
Document Type and Number:
WIPO Patent Application WO/2023/028082
Kind Code:
A3
Abstract:
A method of preparing a covalently conjugated composition includes contacting a MC-GAG scaffold with a solution containing l-ethyl-3-(3- dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS); and further contacting the scaffold with a solution that includes a cross-linking reagent, and a solution that includes OPG, an OPG fragment or an equivalent of each thereof.
Inventors:
LEE JUSTINE C (US)
REN XIAOYAN (US)
HARLEY BRENDAN A (US)
REN XIAOYAN (US)
HARLEY BRENDAN A (US)
Application Number:
PCT/US2022/041269
Publication Date:
May 19, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
UNIV ILLINOIS (US)
UNIV ILLINOIS (US)
International Classes:
A61L27/24; A61K38/16; A61K47/42; A61P19/08; C08J3/24
Foreign References:
| US20210052771A1 | 2021-02-25 | |||
| US20200140844A1 | 2020-05-07 | |||
| US20100248368A1 | 2010-09-30 |
Attorney, Agent or Firm:
LOMPREY, Jeffrey R. et al. (US)
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