Title:
COMPOSITE NANOSTRUCTURES AND METHODS FOR MAKING AND USING THEM
Document Type and Number:
WIPO Patent Application WO/2010/083337
Kind Code:
A3
Abstract:
The invention provides nanostructures or products of manufacture for use as ex vivo or in vivo composition (e.g., a drug, or a therapeutic, diagnostic or imaging reagent) delivery vehicles. In one aspect, the invention provides nanoparticles comprising several compartments which in unison function as a composite nanostructure. In one embodiment, the nanoparticles of the invention comprise a combination of polymer core/lipid bilayer interface which incorporate covalently attached lipid-vascular targeting ligands. These composite nanoparticles can deliver highly effective and selective payloads for diagnostic, prophylactic or therapeutic applications.
Inventors:
WRASIDLO WOLFGANG (US)
MURPHY ERIC (US)
CHERESH DAVID (US)
MAJETY BHARAT K (US)
MURPHY ERIC (US)
CHERESH DAVID (US)
MAJETY BHARAT K (US)
Application Number:
PCT/US2010/021077
Publication Date:
November 25, 2010
Filing Date:
January 14, 2010
Export Citation:
Assignee:
UNIV CALIFORINIA (US)
WRASIDLO WOLFGANG (US)
MURPHY ERIC (US)
CHERESH DAVID (US)
MAJETY BHARAT K (US)
WRASIDLO WOLFGANG (US)
MURPHY ERIC (US)
CHERESH DAVID (US)
MAJETY BHARAT K (US)
International Classes:
B82B3/00
Foreign References:
| US20050058603A1 | 2005-03-17 | |||
| US20030235619A1 | 2003-12-25 | |||
| US20040219205A1 | 2004-11-04 | |||
| US20020048598A1 | 2002-04-25 |
Other References:
JORIS P. SCHILLEMANS ET AL.: "Synthesis of Bilayer-Coated Nanogels by Selecti ve Cross-Linking of Monomers inside Liposomes", MACROMOLECULES, vol. 39, 2006, pages 5885 - 5890
Attorney, Agent or Firm:
EINHORN, Gregory, P. et al. (Dodd & Lindsey LLP4660 La Jolla Village Drive, Suite 75, San Diego CA, US)
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