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Title:
COMPOSITION FOR ACTIVATING PGC-1α
Document Type and Number:
WIPO Patent Application WO/2018/079719
Kind Code:
A1
Abstract:
The purpose of the invention is to provide a composition that has high biological safety and contributes to the activation of PGC-1α. Also, the purpose of the invention is to provide a use for said composition for activating PGC-1α and a method for activating PGC-1α. It was found that a specific compound, among naturally occurring compounds, has a PGC-1α activating action. The invention provides a novel and effective means contributing to improving endurance, increasing muscle size, suppressing obesity, reducing stress, improving sugar metabolic functions, and suppressing muscular atrophy.

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Inventors:
MIURA SHINJI (JP)
MORITA AKIHITO (JP)
MURAYAMA NORIHITO (JP)
SUZUKI TOSHIHIDE (JP)
Application Number:
PCT/JP2017/038930
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
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Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A61K31/12; A61K31/194; A61K31/34; A61K31/341; A61K31/352; A61K31/56; A61K31/7034; A61K31/704; A61K31/7048; A61P3/00; A61P3/02; A61P3/04; A61P3/10; A61P21/00; A61P43/00
Domestic Patent References:
WO2015159272A22015-10-22
Foreign References:
JP2011037811A2011-02-24
JP2007262050A2007-10-11
Other References:
AMAT, R. ET AL.: "SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-gamma Co-activator-1? (PCG-1?) Gene in Skeletal Muscle through the PGC-1? Autoregulatory Loop and Interaction with MyoD", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 33, 2009, pages 21872 - 21880, XP055499268, ISSN: 0021-9258
WAN, Z. ET AL.: "Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue", OBESITY, vol. 22, no. 3, 2014, pages 730 - 738, XP055499273, ISSN: 1930-739X
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
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