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Title:
COMPOSITION AGAINST PERIODONTAL BACTERIA AND FOODS, DRINKS AND MOUTH WASHERS AGAINST PERIODONTAL BACTERIA CONTAINING THE COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2003/099304
Kind Code:
A1
Abstract:
It is intended to provide a composition against periodontal bacteria, which has a high safety without showing any side effects and exhibits an excellent effect of killing periodontal bacteria without affecting the growth of nonpathogenic indigenous microorganisms in the oral cavity, and foods, drinks and mouth washers against periodontal bacteria. A composition against periodontal bacteria is blended with a cocoa fraction contained in cacao mass, a hot water-extract of the cocoa fraction, polyphenols originating in the cocoa fraction or free fatty acids originating in the cocoa fraction as the active ingredient. Then the obtained composition against periodontal bacteria is added to foods, drinks or mouth washers against periodontal bacteria. It is preferable that the above-described cocoa fraction is cocoa and/or cacao mass. It is preferable that the above-described free fatty acids contain at least one member selected from among palmitic acid, stearic acid, oleic acid and linoleic acid.

Inventors:
NISHIMURA EISAKU (JP)
HIRAO CHINAMI (JP)
OHSHIMA TOMOKO (JP)
SATO SUSUMU (JP)
INAGAKI HIROYUKI (JP)
KAMEI MASANORI (JP)
KATO MASATOSHI (JP)
HASHIZUME SHUICHI (JP)
MAEDA NOBUKO (JP)
Application Number:
PCT/JP2003/006614
Publication Date:
December 04, 2003
Filing Date:
May 27, 2003
Export Citation:
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Assignee:
MORINAGA & CO (JP)
NISHIMURA EISAKU (JP)
HIRAO CHINAMI (JP)
OHSHIMA TOMOKO (JP)
SATO SUSUMU (JP)
INAGAKI HIROYUKI (JP)
KAMEI MASANORI (JP)
KATO MASATOSHI (JP)
HASHIZUME SHUICHI (JP)
MAEDA NOBUKO (JP)
International Classes:
A23G1/42; A23G1/48; A23G4/06; A23G4/12; A23L1/30; A23L2/52; A61K8/36; A61K8/97; A61K31/20; A61K31/201; A61P1/02; A61P31/04; A61Q11/00; (IPC1-7): A61K35/78; A61K7/26; A61K31/20; A61K31/201; A61P1/02; A61P31/04
Domestic Patent References:
WO1998009533A11998-03-12
Foreign References:
JP2003089641A2003-03-28
JP2000128801A2000-05-09
JPH07238028A1995-09-12
JP3110020B22000-11-20
Other References:
MASANORI KAMEI ET AL.: "Antibacterial effects of cocoa on helicobacter pylori and results of clinical trials (cocoa no helicobacter pylori sakkin koka oyobi rinsho shiken)", BIOINDUSTRY, vol. 18, no. 12, 2001, pages 5 - 14, XP002971805
NOBUYUKI TANI ET AL.: "Studies on antibacterial effect of root canal sealer (NU-59) (nekan jutenyo sealer NU-59 no kikin koka)", NIHON SHIKA HOZONGAKU ZASSHI, vol. 31, no. 5, 1988, pages 1481 - 1488, XP002971806
FUMINORI KANETSUNA ET AL.: "Bactericidal effect of fatty acids on mycobactera, with particular reference to the suggested mechanism of intracellular killing", MICROBIOL. IMMUNOL., vol. 29, no. 2, 1985, pages 127 - 141, XP002971807
SOUICHI OHTA ET AL.: "Antibiotic activity of unsaturated fatty acids on methicillin-resistant staphylococcus aureus", BIOSCI. BIOTECH. BIOCHEM., vol. 57, no. 12, 1993, pages 2194 - 2195, XP001149161
MUELLER KARL-DIETER ET AL.: "Characterization of the periodontal microflora by the fatty acid profile of the broth-grown microbial population", ZENTRALBLATT FUER BAKTERIOLOGIE, vol. 288, no. 4, 1998, pages 441 - 449, XP002971808
See also references of EP 1508335A4
Attorney, Agent or Firm:
Matsui, Shigeru (Ginza Todoroki Bldg. 16-5, Ginza 8-chome, Chuo-k, Tokyo, JP)
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