Title:
COMPOSITION FOR ALLEVIATING HAIR GRAYING, PROMOTING HAIR GROWTH AND/OR PREVENTING OR ALLEVIATING HAIR LOSS, COMPRISING DOUBLE-STRANDED MIRNA AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/182188
Kind Code:
A1
Abstract:
The present invention relates to a composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded miRNA as an active ingredient and, more specifically, to: miR-3139, miR-3189, miR-3199 or miR-8485, which are double-stranded miRNA; a double-stranded oligonucleotide structure comprising same; or a pharmaceutical or cosmetic composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising nanoparticles containing the structure as an active ingredient. A composition according to the present invention can prevent hair graying and reduce the rate of progress thereof by activating melanocytes and promoting melanogenesis and can allow the hair already affected by graying to be improved to a state before graying. In addition, the composition promotes the activation of melanocytes and the proliferation of dermal papilla cells and keratinocytes that are present in hair follicles, and induces outer root sheath development and hair growth so that the effects of promoting hair growth and/or preventing hair loss can be exhibited.
Inventors:
PARK HAN-OH (KR)
LEE SANG-KYU (KR)
KWON OH SEUNG (KR)
GOH EUN-AH (KR)
LEE SANG-KYU (KR)
KWON OH SEUNG (KR)
GOH EUN-AH (KR)
Application Number:
PCT/KR2022/002765
Publication Date:
September 01, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
BIONEER CORP (KR)
SIRNAGEN THERAPEUTICS CORP (KR)
SIRNAGEN THERAPEUTICS CORP (KR)
International Classes:
A61K48/00; A61K8/60; A61K9/51; A61K31/7105; A61K31/713; A61K47/54; A61K47/58; A61K47/60; A61P17/14
Domestic Patent References:
| WO2016014478A1 | 2016-01-28 |
Foreign References:
| KR20190062263A | 2019-06-05 | |||
| KR101960067B1 | 2019-03-20 | |||
| KR101224828B1 | 2013-01-22 | |||
| KR100883471B1 | 2009-02-16 | |||
| KR101224828B1 | 2013-01-22 | |||
| KR101862349B1 | 2018-05-31 |
Other References:
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AKHTAR S, J. CLIN INVEST., vol. 117, no. 12, 3 December 2007 (2007-12-03), pages 3623 - 3632
S.H. KIM, J. CONTROL RELEASE, vol. 129, no. 2, 2008, pages 107 - 16
D'MELLO, S. A.FINLAY, G. J.BAGULEY, B. C.ASKARIAN-AMIRI, M. E.: "Signaling Pathways in Melanogenesis", INT. J. MOL. SCI., vol. 17, 2016, pages 17
KAWAKAMI AFISHER DE.: "The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology", LAB. INVESTIG., 2017
NIU, C.AISA, H.A.: "Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo", MOLECULES, vol. 22, 2017, pages E1303
LIVAK KJSCHMITTGEN TD., METHODS, vol. 25, no. 4, 2001, pages 4 02 - 8
LIVAK KJSCHMITTGEN TD., METHODS., vol. 25, no. 4, 2001, pages 4 02 - 8
IORNS, E., LORD, C.J., TURNER, N. & ASHWORTH, A., DRUG DISCOV., vol. 6, 2007, pages 556 - 68
AGOSTINI, M.KNIGHT, R.A., ONCOTARGET, vol. 5, 2014, pages 872 - 81
DANGWAL, S.THUM, T., ANNU. REV. PHARMACOLTOXICOL., vol. 54, 2014, pages 185 - 203
CARTHEW, R.W.SONTHEIMER, E.J., CELL, vol. 136, 2009, pages 656 - 68
MACFARLANE, L.-A.MURPHY, P.R., CURRENT GENOMICS, vol. 11, 2010, pages 537 - 561
BRODERSEN, P.VOINNET, O., NAT. REV. MOL. CELL BIOL., vol. 10, 2009, pages 141 - 148
FY XIE., DRUG DISCOV. TODAY., vol. 11, no. 1-2, January 2006 (2006-01-01), pages 67 - 73
AKHTAR S, J., CLIN. INVEST., vol. 117, no. 12, 3 December 2007 (2007-12-03), pages 3623 - 3632
J. SOUTSCHEK, NATURE, vol. 11, no. 432, 2004, pages 7014
S.H. KIM, J., CONTROL RELEASE, vol. 129, no. 2, 2008, pages 107 - 16
FRANCESCO M., VDRUG DISCOVERY TODAY, vol. 10, no. 21, 2005, pages 1451 - 1458
IORNS, E.LORD, C.J.TURNER, N.ASHWORTH, A., NAT. REV. DRUG DISCOV., vol. 6, 2007, pages 556 - 68
AKHTAR S, J. CLIN INVEST., vol. 117, no. 12, 3 December 2007 (2007-12-03), pages 3623 - 3632
S.H. KIM, J. CONTROL RELEASE, vol. 129, no. 2, 2008, pages 107 - 16
D'MELLO, S. A.FINLAY, G. J.BAGULEY, B. C.ASKARIAN-AMIRI, M. E.: "Signaling Pathways in Melanogenesis", INT. J. MOL. SCI., vol. 17, 2016, pages 17
KAWAKAMI AFISHER DE.: "The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology", LAB. INVESTIG., 2017
NIU, C.AISA, H.A.: "Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo", MOLECULES, vol. 22, 2017, pages E1303
LIVAK KJSCHMITTGEN TD., METHODS, vol. 25, no. 4, 2001, pages 4 02 - 8
LIVAK KJSCHMITTGEN TD., METHODS., vol. 25, no. 4, 2001, pages 4 02 - 8
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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