Title:
COMPOSITION FOR CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/265092
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a treatment method that is more practical than currently reported methods in cancer treatment using sodium iodide symporter (NIS)-MSCs, and a composition for cancer treatment that is to be used in the treatment method. More particularly, in the present invention, the means for solving the problem is a composition for cancer treatment that is characterized by comprising a combination of mesenchymal stem cells expressing NIS with an α-nuclide.
Inventors:
NOMURA SACHIYO (JP)
Application Number:
PCT/JP2022/024277
Publication Date:
December 22, 2022
Filing Date:
June 17, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K51/00; A61K35/28; A61K35/545; A61K38/17; A61K48/00; A61P35/00; A61P43/00; A61K101/02
Other References:
KNOOP KERSTIN, KOLOKYTHAS MARIE, KLUTZ KATHRIN, WILLHAUCK MICHAEL J., WUNDERLICH NATHALIE, DRAGANOVICI DAN, ZACH CHRISTIAN, GILDEH: "Image-guided, Tumor Stroma-targeted 131I Therapy of Hepatocellular Cancer After Systemic Mesenchymal Stem Cell-mediated NIS Gene Delivery", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 19, no. 9, 1 September 2011 (2011-09-01), US , pages 1704 - 1713, XP093015207, ISSN: 1525-0016, DOI: 10.1038/mt.2011.93
YUWEI LIU, TADASHI WATABE, KAZUKO KANEDA-NAKASHIMA, KAZUHIRO OOE, YOSHIFUMI SHIRAKAMI, ATSUSHI TOYOSHIMA, EKU SHIMOSEGAWA, TAKASHI: "The comparison of therapeutic effect between [211At]NaAt and [131I]NaI: preclinical study using mice xenograft model of differentiated thyroid cancer", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 62, no. 1, 30 April 2021 (2021-04-30), US , pages 1 - 3, XP009541953, ISSN: 0161-5505
LUNDH CHARLOTTA, LINDENCRONA ULRIKA, POSTGÅRD PER, CARLSSON THERESE, NILSSON MIKAEL, FORSSELL-ARONSSON EVA: "Radiation-Induced Thyroid Stunning: Differential Effects of 123 I, 131 I, 99m Tc, and 211 At on Iodide Transport and NIS mRNA Expression in Cultured Thyroid Cells", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 50, no. 7, 1 July 2009 (2009-07-01), US , pages 1161 - 1167, XP093015211, ISSN: 0161-5505, DOI: 10.2967/jnumed.108.061150
THORSTEN PETRICH, ZEKIYE KORKMAZ, RAMONA WILD, JAVAD MIRZAYAN, GEERD MEYER, STRIPECKE RENATA, KNAPP WOLFRAM, FRANK BENGEL: "Tumor cell toxicity of astatine-211 compared to iodine-131 after transfection of the sodium/iodide-symporter (NIS) gene (Poster 1121)", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 53, no. Suppl. 1, 1 May 2012 (2012-05-01), US , pages 1121, XP009541951, ISSN: 0161-5505
MICHAEL J. WILLHAUCK ; BIBI-RANA SHARIF SAMANI ; INGO WOLF ; REINGARD SENEKOWITSCH-SCHMIDTKE ; HANS-JüRGEN STARK ; GEERD J. MEYER: "The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, BERLIN, DE, vol. 35, no. 7, 11 April 2008 (2008-04-11), Berlin, DE , pages 1272 - 1281, XP019624170, ISSN: 1619-7089
NOMURA, SACHIYO: "Analysis of the treatment for gastric cancer peritoneal metastasis using hyper-selective short lived alpha-emitting radio isotope", 2019 PERFORMANCE REPORT; KAKENHI-PROJECT-19H03510, KAKEN, JP, JP, pages 1 - 1, XP009542992, Retrieved from the Internet
YUWEI LIU, TADASHI WATABE, KAZUKO KANEDA-NAKASHIMA, KAZUHIRO OOE, YOSHIFUMI SHIRAKAMI, ATSUSHI TOYOSHIMA, EKU SHIMOSEGAWA, TAKASHI: "The comparison of therapeutic effect between [211At]NaAt and [131I]NaI: preclinical study using mice xenograft model of differentiated thyroid cancer", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 62, no. 1, 30 April 2021 (2021-04-30), US , pages 1 - 3, XP009541953, ISSN: 0161-5505
LUNDH CHARLOTTA, LINDENCRONA ULRIKA, POSTGÅRD PER, CARLSSON THERESE, NILSSON MIKAEL, FORSSELL-ARONSSON EVA: "Radiation-Induced Thyroid Stunning: Differential Effects of 123 I, 131 I, 99m Tc, and 211 At on Iodide Transport and NIS mRNA Expression in Cultured Thyroid Cells", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 50, no. 7, 1 July 2009 (2009-07-01), US , pages 1161 - 1167, XP093015211, ISSN: 0161-5505, DOI: 10.2967/jnumed.108.061150
THORSTEN PETRICH, ZEKIYE KORKMAZ, RAMONA WILD, JAVAD MIRZAYAN, GEERD MEYER, STRIPECKE RENATA, KNAPP WOLFRAM, FRANK BENGEL: "Tumor cell toxicity of astatine-211 compared to iodine-131 after transfection of the sodium/iodide-symporter (NIS) gene (Poster 1121)", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 53, no. Suppl. 1, 1 May 2012 (2012-05-01), US , pages 1121, XP009541951, ISSN: 0161-5505
MICHAEL J. WILLHAUCK ; BIBI-RANA SHARIF SAMANI ; INGO WOLF ; REINGARD SENEKOWITSCH-SCHMIDTKE ; HANS-JüRGEN STARK ; GEERD J. MEYER: "The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, SPRINGER, BERLIN, DE, vol. 35, no. 7, 11 April 2008 (2008-04-11), Berlin, DE , pages 1272 - 1281, XP019624170, ISSN: 1619-7089
NOMURA, SACHIYO: "Analysis of the treatment for gastric cancer peritoneal metastasis using hyper-selective short lived alpha-emitting radio isotope", 2019 PERFORMANCE REPORT; KAKENHI-PROJECT-19H03510, KAKEN, JP, JP, pages 1 - 1, XP009542992, Retrieved from the Internet
Attorney, Agent or Firm:
OKUHARA Koji (JP)
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