COMPOSITION CAPABLE OF ACTIVATING NATURAL KILLER CELLS AND PROCESS FOR PRODUCING THE SAME, COMPOSITION CONTAINING NATURAL KILLER CELLS ACTIVATED BY THE FORMER COMPOSITION AND PROCESS FOR PRODUCING THE SAME

Title:

Document Type and Number:

WIPO Patent Application WO/2004/061090

Kind Code:

A1

Abstract:

A composition capable of activating natural killer cells comprising a fraction which is substantially free from uronic acid, contains polysaccharides comprising xylose, arabinose and glucose and is insoluble in an organic acid solvent. This fraction is obtained by subjecting barley shochu (distilled spirit) stillage to solid-liquid separation to give a liquid, subjecting this liquid to an ion exchange treatment using an ion exchange resin to give a fraction (a) not adsorbed by the ion exchange resin, or subjecting the above-described liquid to an adsorption separation treatment using a synthetic adsorbent to give a fraction (b) not adsorbed by the synthetic adsorbent, then subjecting this fraction (b) to an ion exchange treatment using an ion exchange resin to give the above-described fraction (a), concentrating the thus obtained fraction (a) by ultrafiltration using an ultrafiltration membrane to give a liquid concentrate, and adding the above-described organic solvent to the liquid concentrate. A composition containing natural killer cells having been inactivated with the use of the above composition.

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Inventors:

OMORI TOSHIRO (JP)
UMEMOTO YASUFUMI (JP)
FURUTA YOSHIFUMI (JP)
HOKAZONO HIDEKI (JP)
FURUTERA MIHOKO (JP)
OHBA HIDEKI (JP)

Application Number:

PCT/JP2004/000003

Publication Date:

July 22, 2004

Filing Date:

January 05, 2004

Export Citation:

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Assignee:

SANWA SHURUI CO LTD (JP)
BARLEY FERMENTATION TECHNOLOGI (JP)
NAT INST OF ADVANCED IND SCIEN (JP)
OMORI TOSHIRO (JP)
UMEMOTO YASUFUMI (JP)
FURUTA YOSHIFUMI (JP)
HOKAZONO HIDEKI (JP)
FURUTERA MIHOKO (JP)
OHBA HIDEKI (JP)

International Classes:

A61K31/716; A61K35/14; A61K35/17; A61K36/00; A61K36/06; A61K36/899; A61K36/8998; A61P1/16; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C12N5/07; C12N5/0783; C12P1/00; A61K131/00; (IPC1-7): C12N5/06; C12N5/08; C12P1/00; A61K35/74; A61K35/72; A61K35/78; A61P1/16

Foreign References:

JPH0923895A	1997-01-28
JP2003221342A	2003-08-05
JP2001145472A	2001-05-29
JPH10146166A	1998-06-02
JP2002255843A	2002-09-11
JP2001161339A	2001-06-19
JP2003073294A	2003-03-12

Other References:

KUKIZAKI MASATO: "Shochu joryu haieki jikomi no yoru shcho seizo no closed-ka ni kansuru kenkyu", MIYAZAKI-KEN KOGYO SHIKENJO KENKYU HOKOKU, vol. 32, 1987, pages 51 - 54, XP002982751

Attorney, Agent or Firm:

Sudo, Asako (Kajino-cho Koganei-shi, Tokyo, JP)

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