Title:
COMPOSITION CAPABLE OF PROMOTING PROLIFERATION OF FIBROBLAST
Document Type and Number:
WIPO Patent Application WO/2013/129456
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel composition that can promote the proliferation of a fibroblast and can activate the proliferation ability of a fibroblast, which has been deteriorated by an external factor such as ultraviolet ray, aging or the like, and therefore is useful for improving wrinkling or sagging of the skin, recovering tension or elasticity of the skin or improving the moisture-retaining function of the skin, and can be used effectively for cosmetic purposes.
A composition comprising: (A) a peptide comprising an amino acid sequence represented by formula (I) Xaa1-Asp-Leu-Asp-Val-Xaa2 (SEQ ID NO: 1) [wherein Xaa1 and Xaa2 may be present or absent and, if present, independently represent an arbitrary amino acid residue], a derivative thereof of the peptide, or a salt of the peptide or the derivative; and (B) a polysaccharide.
Inventors:
MIZUTARE YOKO (JP)
ABE MASAMICHI (JP)
KUMAZAWA MASUNORI (JP)
MATSUMOTO KOSUKE (JP)
ABE MASAMICHI (JP)
KUMAZAWA MASUNORI (JP)
MATSUMOTO KOSUKE (JP)
Application Number:
PCT/JP2013/055084
Publication Date:
September 06, 2013
Filing Date:
February 27, 2013
Export Citation:
Assignee:
ROHTO PHARMA (JP)
International Classes:
A61K8/64; A23L1/30; A61K8/73; A61K31/717; A61K31/718; A61K31/719; A61K31/721; A61K31/722; A61K31/727; A61K31/728; A61K31/729; A61K31/732; A61K31/734; A61K31/736; A61K31/737; A61K38/00; A61P17/18; A61P43/00; A61Q19/08; C07K7/06
Domestic Patent References:
| WO2012144546A1 | 2012-10-26 |
Foreign References:
| US7402407B1 | 2008-07-22 | |||
| JPS60500673A | 1985-05-09 | |||
| JP2009079043A | 2009-04-16 | |||
| JP2006143605A | 2006-06-08 | |||
| JP2010077046A | 2010-04-08 |
Other References:
HASHIMOTO, Y. ET AL.: "Identification of an Autoinhibitory Domain in Calcineurin", J. BIOL. CHEM., vol. 265, no. 4, 1990, pages 1924 - 1927
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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Claims: