Title:
COMPOSITION FOR CARTILAGE REPAIR AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2024/024708
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel composition for cartilage repair including cells that have characteristics suitable for cartilage repair, and a method for producing same. With a focus on umbilical cord tissue-derived cells, three-dimensional culturing of umbilical cord tissue-derived cells was carried out. It was found that umbilical cord tissue-derived cells constituting a culture obtained by three-dimensional culturing have cell proliferation ability and gene expression level characteristics different from those of cells constituting a culture obtained by three-dimensional culturing of cells derived from other tissues. The umbilical cord tissue-derived cells constituting a culture obtained by three-dimensional culturing of the present invention have characteristics suitable for cartilage repair and make it possible to provide a composition effective for cartilage repair.
Inventors:
NAKATA KEN (JP)
KANAMOTO TAKASHI (JP)
OTANI SHUNYA (JP)
KANAMOTO TAKASHI (JP)
OTANI SHUNYA (JP)
Application Number:
PCT/JP2023/026944
Publication Date:
February 01, 2024
Filing Date:
July 24, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61L27/38; A61K35/51; A61P19/04; C12M1/00; C12M3/00; C12N5/077
Foreign References:
| JP2007528706A | 2007-10-18 | |||
| CN107185047A | 2017-09-22 | |||
| CN106434522A | 2017-02-22 | |||
| JP2001502905A | 2001-03-06 |
Other References:
ZHANG XIAOGUANG; LIU SHAOKAI; WANG ZHENXING; LUO CHAO; DAI ZHIPENG; SUN JIAMING; LIU YONG; SHAO ZENGWU; YANG SHUHUA; WANG HUI; WAN: "Implanted 3D gelatin microcryogel enables low-dose cell therapy for osteoarthritis by preserving the viability and function of umbilical cord MSCs", CHEMICAL ENGENEERING JOURNAL, ELSEVIER, AMSTERDAM, NL, vol. 416, 25 February 2021 (2021-02-25), AMSTERDAM, NL , XP086554953, ISSN: 1385-8947, DOI: 10.1016/j.cej.2021.129140
YUN CHU; LEI HUANG; WANGPING HAO; TONGTONG ZHAO; HAITAO ZHAO; WEN YANG; XIN XIE; LIN QIAN; YANYAN CHEN; JIANWU DAI: "Long-term stability, high strength, and 3D printable alginate hydrogel for cartilage tissue engineering application", BIOMEDICAL MATERIALS, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 16, no. 6, 28 September 2021 (2021-09-28), GB , pages 064102, XP020370103, ISSN: 1748-605X, DOI: 10.1088/1748-605X/ac2595
YUN CHU; LEI HUANG; WANGPING HAO; TONGTONG ZHAO; HAITAO ZHAO; WEN YANG; XIN XIE; LIN QIAN; YANYAN CHEN; JIANWU DAI: "Long-term stability, high strength, and 3D printable alginate hydrogel for cartilage tissue engineering application", BIOMEDICAL MATERIALS, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 16, no. 6, 28 September 2021 (2021-09-28), GB , pages 064102, XP020370103, ISSN: 1748-605X, DOI: 10.1088/1748-605X/ac2595
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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