COMPOSITION COMPRISING BENZOIC ACID AMIDE COMPOUND AND SOLUBILIZING AGENT

WIPO Patent Application WO/2018/062958

A1

The present specification relates to a skin external composition comprising: a solute which is a benzoic acid amide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof; and at least one first solubilizing agent selected from among diethylene glycol monoethyl ether, methyl gluceth, glycerol ether, polyethylene glycol, and a polyethylene glycol/propylene glycol copolymer, and provides a skin external composition with improved solubility and feeling of use.

YI CHANG GEUN (KR)
CHOI JOONHO (KR)
SHIN HONG-JU (KR)
JEONG YEON SU (KR)
KIM JEONG-HWAN (KR)
KIM SUIL (KR)
KO JAEYOUNG (KR)
JOO YUNG HYUP (KR)
BAEK HEUNG SOO (KR)
LIM HYUNG JUN (KR)
LEE CHANG SEOK (KR)

PCT/KR2017/011012

April 05, 2018

September 29, 2017

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AMOREPACIFIC CORP (KR)

A61K31/166; A61K8/42; A61Q19/00; A61Q19/02

KR20130015954A	2013-02-14
KR20050109385A	2005-11-21
KR20160116941A	2016-10-10

HONG, Y. D.: "3D-QSAR study of adamantyl N-benzylbenzamides as melanogenesis inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, XP055167578
LEE, C. S.: "A novel adamantyl benzylbenzamide derivative, AP 736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression", EXPERIMENTAL DERMATOLOGY, vol. 22, no. 11, 2013, pages 762 - 764, XP055331206, DOI: doi:10.1111/exd.12248

KIM, Sun-young (KR)

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