Title:
COMPOSITION COMPRISING EXOSOMES DERIVED FROM FELINE MESENCHYMAL STEM CELLS AND METHOD OF TREATING INFLAMMATORY DISEASES BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/251616
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, treating, or alleviating inflammatory diseases, which comprises exosomes derived from feline mesenchymal stem cells; and a method of treating inflammatory diseases in a feline by using the composition. The present invention has found that the expression of anti-inflammatory factor IL-10 is higher in exosomes derived from adipose-derived mesenchymal stem cells than in fibroblast-derived exosomes, and when the exosomes are used to treat macrophages, the expression of pro-inflammatory factors decreases while the expression of anti-inflammatory factors increases. Thus, the exosomes derived from feline adipose-derived mesenchymal stem cells may be advantageously used for the treatment of inflammatory diseases.
Inventors:
SEO MIN SOO (KR)
KANG KYUNG KU (KR)
SUNG SOO EUN (KR)
CHOI JOO HEE (KR)
LEE SI JOON (KR)
KIM KIL SOO (KR)
YUN SUNG HO (KR)
KWON YOUNG SAM (KR)
KANG KYUNG KU (KR)
SUNG SOO EUN (KR)
CHOI JOO HEE (KR)
LEE SI JOON (KR)
KIM KIL SOO (KR)
YUN SUNG HO (KR)
KWON YOUNG SAM (KR)
Application Number:
PCT/KR2021/005093
Publication Date:
December 16, 2021
Filing Date:
April 22, 2021
Export Citation:
Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
International Classes:
A61K35/28; A23K10/20; A23K20/147; A23K50/40; A61K38/20; A61P29/00
Domestic Patent References:
| WO2019099927A1 | 2019-05-23 |
Foreign References:
| JP2018531979A | 2018-11-01 | |||
| US20150190429A1 | 2015-07-09 | |||
| KR101776886B1 | 2017-09-08 | |||
| US20200163998A1 | 2020-05-28 |
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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